Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: An electric circular saw includes a housing, a switch trigger arranged on the housing, a switch controlling rod for limiting the travel range of the switch trigger, a base plate, a depth support arranged on the base plate and a connecting rod for limiting the travel range of the depth support. The electric circular saw further includes an movable control member having a driving portion for driving the first connecting rod and a limiting portion for limiting the switch controlling rod, and the moving distance from the driving portion to a contact surface between the driving portion and the first connecting rod is larger than or equal to the moving distance from the limiting portion to a contact surface between the limiting portion and the switch controlling rod.

Abstract: Aspects of the subject matter described herein relate to software validation. In aspects, code may be instrumented to generate certain records upon execution. The code may be further instrumented to generate start and stop records that correspond to the start and stop events of a scenario of a program. The start and stop event records allow correlation of the scenario with other records written to the log. With the correlation and appropriate instrumentation, a tool may determine performance, memory usage, functional correctness, and other characteristics of program at the granularity of the scenario.

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract: The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract: A guiding mechanism for an electric tool includes at least two guiding elements at least one of which has a first end portion having at least one protruding portion extending outwards therefrom and the other of which has a second end portion having at least one groove therein which may be engaged with the protruding portion. The groove has a cut-out and the protruding portion has an elastic clamping portion which may be engaged with the cut-out.

Abstract: The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylamino benzoic acid derivatives represented by specific Chemical formulas or their salts, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino]benzoic acid or its salt.

Abstract: A method for treating a cancer is disclosed, which comprises: administering an effective amount of Fe-based particles to a subject in need, wherein the Fe-based particles have core-shell structures. Herein, each Fe-based particle of the present invention comprises: an Fe elemental core with zero valent irons; and a covering layer formed on partial or whole surface of the Fe elemental core, wherein a material of the covering layer is a metal, a metal doped with dopants, a metal alloy, a polymer, carbon, a metal oxide or a nonmetal oxide, and the shape of the Fe-based particles is a rod, a sphere, a cubic or a dumbbell, with the proviso that the metal is not Au.

Abstract: A method for treating a cancer is disclosed, which comprises: administering an effective amount of Fe-containing alloy particles to a subject in need, wherein a material of each Fe-containing alloy particle is an alloy comprising a first metal of Fe and a second metal.

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract: A guiding mechanism for an electric tool includes at least two guiding elements at least one of which has a first end portion having at least one protruding portion extending outwards therefrom and the other of which has a second end portion having at least one groove therein which may be engaged with the protruding portion. The groove has a cut-out and the protruding portion has an elastic clamping portion which may be engaged with the cut-out.

Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.

Abstract: A circular saw includes a housing, a motor having a rotating axis and a center of gravity on the rotating axis, a handle, a circular blade, a fixed guard, and a base plate having a width supporting the housing. The motor and the circular blade are parallel or coplanar with respect to each other and the circular saw does not extend beyond the width of the base plate in the width direction.

Abstract: The present invention relates to a guide rail for a power tool with an auxiliary guide component having a locating block and a main guide component. The guide rail has a fixing device to connect the auxiliary guide component to the main guide component. The locating block has a taper-tilted edge that may be connected to a corresponding edge of the fixing device. Using the tapered fitting, the main guide component and the auxiliary guide component can be quickly connected or disconnected to adjust the positions of the auxiliary guide component and the main guide component during operation. The present invention may further include angle-indication marks. By setting the angle-indication marks on the auxiliary guide component, cutting at a certain angle can be achieved quickly to improve the convenience and efficiency of operation by the user.

Abstract: The present invention provides an efficient method for mass-producing 2-hydroxy-5-(substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[2-(4-trifluoromethylphenyl)ethylamino] benzoic acid or its salt.