Abstract: The present invention relates to a substrate of a metal, preferably titanium or a titanium alloy, having at least one surface coated with an oxide layer of the metal itself, said surface being modified and enriched with Ca, P, Ga, Sr, and, optionally, Ag by anodic spark deposition (ASD). The present invention also relates to a process for producing said substrate by applying the anodic spark deposition (ASD) technique to a substrate, optionally pre-treated, immersed in an electrolytic solution comprising Ca, P, Ga, Sr and, optionally, Ag. Finally, the present invention also relates to a prosthesis and a surgical implant comprising or preferably produced with said substrate, as well as the use thereof for the prevention of bacterial colonisation and promotion of osteointegration in implantology operations, preferably orthopaedic prosthetic implantology.

Abstract: Use of rutin for increasing the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to chemotherapeutics currently in use.

Abstract: Use of rutin for increasing the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumors is described, in particular in case of resistance to chemotherapeutics currently in use.

Abstract: The invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1?X/Y)·100 wherein: Y=height of the diffraction maximum at 2?=33°, X=height of the diffraction background at 2?=33° of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products.

Abstract: The invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1?X/Y)·100 wherein: Y=height of the diffraction maximum at 2?=33°, X=height of the diffraction background at 2?=33° of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products.