Abstract: Systems and methods of an electronic drug delivery system for use in a treatment program (e.g., a smoking cessation program). The delivery system can include a mobile platform and a hand-held inhalation delivery device having a controller circuit coupled to a power source, sensors, aerosolizer drivers, and a rescue button, and a pod removably coupled to the delivery device. The delivery system generates an aerosol mixture from substances in the pod in accordance with the treatment program, and delivers the aerosol mixture for inhalation by a user. The controller circuit individually and dynamically controls the aerosolizer drivers to generate signals that drive a plurality of thermal, or non-thermal, aerosolizers of the pod to generate individually tailored aerosol mixtures from multiple substances in the aerosolizer pod. The generated aerosol mixtures can have various percentages of the substances, and have different aerosol droplet sizes during different portions of the treatment program.