Patents by Inventor Liam CHEN

Liam CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-associated viral chimeric TDP-43 proteins
    Patent number: 12202867
    Abstract: An adenovirus or adenoviral vector is described that includes a non-native nucleotide sequence capable of expressing a chimeric protein comprising an N-terminal nucleotide binding domain of transactivation response element DNA-binding protein (TDP-43), a C-terminal domain derived from a splicing repressor, and an autoregulatory element. Methods of using the adenovirus or adenoviral vector to treat degenerative diseases such as inclusion body myocytosis, amyotrophic lateral sclerosis, and frontotemporal dementia are also described.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: January 21, 2025
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Philip C. Wong, Aneesh Donde, Jonathan P. Ling, Liam Chen, Mingkuan Sun
  • ADENOVIRAL CHIMERIC TDP-43 PROTEINS
    Publication number: 20220275034
    Abstract: An adenovirus or adenoviral vector is described that includes a non-native nucleotide sequence capable of expressing a chimeric protein comprising an N-terminal nucleotide binding domain of transactivation response element DNA-binding protein (TDP-43), a C-terminal domain derived from a splicing repressor, and an autoregulatory element. Methods of using the adenovirus or adenoviral vector to treat degenerative diseases such as inclusion body myocytosis, amyotrophic lateral sclerosis, and frontotemporal dementia are also described.
    Type: Application
    Filed: November 4, 2019
    Publication date: September 1, 2022
    Inventors: Philip C. WONG, Aneesh DONDE, Jonathan P. LING, Liam CHEN, Mingkuan SUN