Abstract: A method for determining geometry of a face mask comprising a main body and a seal configured to engage a nasal region, cheeks and a chin of a user. The method comprises collecting (402) facial data of the user comprising a point cloud comprising a plurality of points on a skin surface in a nasal region, eye region and chin region of the user; determining (406), based on the facial data, in at least one of the eye region and the chin region of the user, an estimated face size of the user; determining (408), based on the facial data comprising the plurality of points in the nasal region, a best-fit Gaussian curve to a profile of a nose of the user; and using the estimated face size of the user and the determined Gaussian curve to select (410) parameters for a profile geometry of the face mask.

Abstract: The invention relates to a surgical or wound dressing comprising a sheet of gellan gum and an antifibrotic agent. Methods of producing dressings comprising gellan gums and biologically active agents area also produced.

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

Abstract: Provided are pharmaceutical compositions comprising a sulphated polysaccharide and a shear-thinning fluid gel. The sulphated polysaccharide may, by way of example, be selected from the group consisting of: a dextran sulphate having an average molecular weight of 10,000 Da or less; heparan sulphate; fucoidan; poligeenan; furcellaran; and a carrageenan. The shear-thinning fluid gel may comprise a microgel particle forming polymer, suitably selected from one or more of the following groups: gellans; alginates; carrageenans; agarose; chitosan; pectin; agarose; agar or gelatin. The compositions disclosed may be used for the prevention and/or treatment of glaucoma. These compositions may be used for the inhibition or reduction of fibrosis. The invention also relates to the medical uses of sulphated polysaccharides, and the medical uses of shear-thinning fluid gels.

Abstract: Disclosed are shear-thinning hydrogel compositions comprising 0.1 to 5 wt. % (such as 0.1 to 2.5 wt. %) of a microgel particle-forming polymer; and 0.5 to 100 mM of a monovalent and/or polyvalent metal ion salt as a cross-linking agent. The microgel particle-forming polymer is dispersed in an aqueous vehicle, and the hydrogel composition has a pH within the range of 3 to 8. The viscosity of the gel composition reduces when the gel is exposed to shear. Also disclosed are methods of making such compositions, and medical uses of such compositions.

Abstract: Provided are shear-thinning ocular hydrogel compositions that comprise 0.1 to 5.0 wt. % (e.g. 0.1 to 3.5 wt. % or 0.1 to 2.5 wt. %) of a microgel particle-forming polymer; and 0.5 to 100 mM of a monovalent and/or polyvalent metal ion salt as a cross-linking agent; dispersed in an aqueous vehicle. The hydrogel compositions have a pH within the range of 3 to 8 and the viscosity of the gel composition reduces when the gel is exposed to shear. The compositions comprise decorin. The may also comprise an antibiotic, such as gentamicin, and an anti-inflammatory steroid, such as prednisolone. The compositions are suitable for medical use in the treatment of the eye. For example, the compositions are suitable for use in the inhibition of scarring and/or the prevention or treatment of microbial keratitis.

Abstract: The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents. Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.

Abstract: The invention relates to a surgical or wound dressing comprising a sheet of gellan gum and an antifibrotic agent. Methods of producing dressings comprising gellan gums and biologically active agents area also produced.

Abstract: The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents. Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.

Abstract: Described herein are surgical or wound dressings comprising a sheet of gellan gum and an antifibrotic agent. Methods for producing dressings comprising gellan gums and biologically active agents are also described.

Abstract: The application discloses hydrogel wound treatment formulation containing collagen and decorin, and optionally fibrin. This is especially useful for the treatment of the eye. Wound dressings comprising the formulation are also provided, for example in the form of a gellan sheet.

Abstract: The invention provides a cell delivery medium comprising a liquid phase, wherein the liquid phase comprises (i) one or more cells suspended within the liquid phase and (ii) a plurality of polymer gel particulates. Methods of producing the cell delivery systems are also provided.

Abstract: The invention relates to bone cement compositions comprising a calcium component and a liquid component in which the liquid component comprises pyrophosphate ions with either orthophosphate ions or water, or with both orthophosphate ions and water.