Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: A method, computer program product, and computing system for determining whether storage space usage on a storage system has reached a predefined threshold of a total storage capacity of the storage system. An out-of-space mode may be initiated on the storage system in response to determining that the storage space usage has reached the predefined threshold of the total storage capacity of the storage system. An amount of free storage capacity for exiting the out-of-space mode may be determined based upon, at least in part, a predefined minimum free storage capacity, a predefined maximum free storage capacity, and the total storage capacity of the storage system.

Abstract: A method, computer program product, and computing system for determining whether storage space usage on a storage system has reached a predefined threshold of a total storage capacity of the storage system. An out-of-space mode may be initiated on the storage system in response to determining that the storage space usage has reached the predefined threshold of the total storage capacity of the storage system. An amount of free storage capacity for exiting the out-of-space mode may be determined based upon, at least in part, a predefined minimum free storage capacity, a predefined maximum free storage capacity, and the total storage capacity of the storage system.

Abstract: Embodiments of the present disclosure provide a method, an apparatus and a computer program product for managing an input/output (I/O). The method comprises, in response to receiving a first I/O request of a first type for a storage device, determining whether there exists at least one credit available to the first type of I/O requests. Each of the at least one credit indicates I/O processing capability reserved by the storage device for the first type of I/O requests. The method further comprises allocating a first credit to the first I/O request based on a result of the determining. The method further comprises performing, by using the first credit, an I/O operation requested by the first I/O request on the storage device. Moreover, the method further comprises, in response to completion of the I/O operation, recycling the first credit for use by a subsequent I/O request. Embodiments of the present disclosure can implement dynamic allocation of I/O processing capability for different types of I/Os.

Abstract: Embodiments of the present disclosure provide a method of storage allocation, an electronic device, a storage system and a computer program product. The method of storage allocation includes: obtaining respective wear levels of a plurality of disks associated with a redundant array of independent disks (RAID). The method further includes: determining respective spare extents in disk extents of the plurality of disks based on the obtained wear levels, such that a number of spare extents in a disk is positively correlated with the wear level of the disk. The method also includes: selecting, from disk extents other than the spare extents, a predetermined number of disk extents for creating RAID extents for the RAID, the predetermined number of disk extents being from different disks of the plurality of disks. Through the embodiments of the present disclosure, a life cycle of a disk is prolonged, frequent replacement of worn disks with new disks is avoided, and data loss is reduced.

Abstract: Embodiments of the present disclosure relate to a method and device for flushing pages from a solid-state storage device. Specifically, the present disclosure discloses a method of flushing pages from a solid-state storage device comprising: determining a first number based on a period length of one flushing cycle and a period length required for building one flushing transaction, the first number indicating a maximum number of flushing transactions that can be built in the flushing cycle; and flushing pages from the solid-state storage device with an upper limit of the first number in the flushing cycle. The present disclosure also discloses a device for flushing pages from a solid-state storage device and a computer program product for implementing steps of a method of flushing pages from a solid-state storage device.

Abstract: A computer-implemented method for establishing a multi-tier flash cache using spare drives. The method includes, in response to receiving an I/O request, determining that there is no free page in a main cache. Having determined that there is no free page in the main cache, the method further includes establishing a secondary cache by selecting at least one spare drive from a plurality of spare drives, flushing data from a cold page in the main cache to the secondary cache, an access frequency of the cold page being lower than a predetermined threshold, and writing data related to the I/O request from a persistent storage device to the cold page.

Abstract: Embodiments of the present disclosure provide a method, an apparatus and a computer program product for managing an input/output (I/O). The method comprises, in response to receiving a first I/O request of a first type for a storage device, determining whether there exists at least one credit available to the first type of I/O requests. Each of the at least one credit indicates I/O processing capability reserved by the storage device for the first type of I/O requests. The method further comprises allocating a first credit to the first I/O request based on a result of the determining. The method further comprises performing, by using the first credit, an I/O operation requested by the first I/O request on the storage device. Moreover, the method further comprises, in response to completion of the I/O operation, recycling the first credit for use by a subsequent I/O request. Embodiments of the present disclosure can implement dynamic allocation of I/O processing capability for different types of I/Os.

Abstract: Embodiments of the present disclosure provide a method, an apparatus and a computer program product for managing an input/output (I/O). The method comprises, in response to receiving a first I/O request of a first type for a storage device, determining whether there exists at least one credit available to the first type of I/O requests. Each of the at least one credit indicates I/O processing capability reserved by the storage device for the first type of I/O requests. The method further comprises allocating a first credit to the first I/O request based on a result of the determining. The method further comprises performing, by using the first credit, an I/O operation requested by the first I/O request on the storage device. Moreover, the method further comprises, in response to completion of the I/O operation, recycling the first credit for use by a subsequent I/O request. Embodiments of the present disclosure can implement dynamic allocation of I/O processing capability for different types of I/Os.

Abstract: Embodiments of the present disclosure provide a method of storage allocation, an electronic device, a storage system and a computer program product. The method of storage allocation includes: obtaining respective wear levels of a plurality of disks associated with a redundant array of independent disks (RAID). The method further includes: determining respective spare extents in disk extents of the plurality of disks based on the obtained wear levels, such that a number of spare extents in a disk is positively correlated with the wear level of the disk. The method also includes: selecting, from disk extents other than the spare extents, a predetermined number of disk extents for creating RAID extents for the RAID, the predetermined number of disk extents being from different disks of the plurality of disks. Through the embodiments of the present disclosure, a life cycle of a disk is prolonged, frequent replacement of worn disks with new disks is avoided, and data loss is reduced.

Abstract: Embodiments of the present disclosure provide a method of storage allocation, an electronic device, a storage system and a computer program product. The method of storage allocation includes: obtaining respective wear levels of a plurality of disks associated with a redundant array of independent disks (RAID). The method further includes: determining respective spare extents in disk extents of the plurality of disks based on the obtained wear levels, such that a number of spare extents in a disk is positively correlated with the wear level of the disk. The method also includes: selecting, from disk extents other than the spare extents, a predetermined number of disk extents for creating RAID extents for the RAID, the predetermined number of disk extents being from different disks of the plurality of disks. Through the embodiments of the present disclosure, a life cycle of a disk is prolonged, frequent replacement of worn disks with new disks is avoided, and data loss is reduced.

Abstract: Embodiments of the present disclosure provide a cache system and associated method. The cache system includes a first pipeline module including a first plurality of sequential processing phases for executing a plurality of operations. The first plurality of operations is executed in response to Input/Output (I/O) requests of a first plurality of types for the persistent storage device, and each of the first plurality of operations is a common operation for the I/O requests of at least two of the first plurality of types. The cache system also includes a control module configured to: determine a first type of a first pending processing I/O request for the persistent storage device, and in response to the first type being one of the first plurality of types, cause the first pipeline module to be executed to process the first pending processing I/O request.

Abstract: Embodiments of the present disclosure provide a method for managing a storage system, an apparatus and a computer readable storage medium. The method comprises: determining a permitted concurrency number for respective access to multiple storage devices in the storage system by a multi-level cache device of the storage system, the permitted concurrency number being associated with a state of the multiple storage devices; in response to receiving an access request for the storage system, determining a cache device in the multi-level cache device corresponding to the access request; determining whether a current concurrency number of access to the multiple storage devices in the cache device reaches the permitted concurrency number; and in response to determining that the current concurrency number fails to reach the permitted concurrency number, executing the access request for the storage system.

Abstract: Embodiments of the present disclosure relate to a method and device for flushing pages from a solid-state storage device. Specifically, the present disclosure discloses a method of flushing pages from a solid-state storage device comprising: determining a first number based on a period length of one flushing cycle and a period length required for building one flushing transaction, the first number indicating a maximum number of flushing transactions that can be built in the flushing cycle; and flushing pages from the solid-state storage device with an upper limit of the first number in the flushing cycle. The present disclosure also discloses a device for flushing pages from a solid-state storage device and a computer program product for implementing steps of a method of flushing pages from a solid-state storage device.

Abstract: Embodiments of the present disclosure relate to a method and device for flushing pages from a solid-state storage device. Specifically, the present disclosure discloses a method of flushing pages from a solid-state storage device comprising: determining a first number based on a period length of one flushing cycle and a period length required for building one flushing transaction, the first number indicating a maximum number of flushing transactions that can be built in the flushing cycle; and flushing pages from the solid-state storage device with an upper limit of the first number in the flushing cycle. The present disclosure also discloses a device for flushing pages from a solid-state storage device and a computer program product for implementing steps of a method of flushing pages from a solid-state storage device.

Abstract: Embodiments of the present disclosure provide a method, an apparatus and a computer program product for managing an input/output (I/O). The method comprises, in response to receiving a first I/O request of a first type for a storage device, determining whether there exits at least one credit available to the first type of I/O requests. Each of the at least one credit indicates I/O processing capability reserved by the storage device for the first type of I/O requests. The method further comprises allocating a first credit to the first I/O request based on a result of the determining. The method further comprises performing, by using the first credit, an I/O operation requested by the first I/O request on the storage device. Moreover, the method further comprises, in response to completion of the I/O operation, recycling the first credit for use by a subsequent I/O request. Embodiments of the present disclosure can implement dynamic allocation of I/O processing capability for different types of I/Os.

Abstract: Embodiments of the present disclosure provide a method of storage allocation, an electronic device, a storage system and a computer program product. The method of storage allocation includes: obtaining respective wear levels of a plurality of disks associated with a redundant array of independent disks (RAID). The method further includes: determining respective spare extents in disk extents of the plurality of disks based on the obtained wear levels, such that a number of spare extents in a disk is positively correlated with the wear level of the disk. The method also includes: selecting, from disk extents other than the spare extents, a predetermined number of disk extents for creating RAID extents for the RAID, the predetermined number of disk extents being from different disks of the plurality of disks. Through the embodiments of the present disclosure, a life cycle of a disk is prolonged, frequent replacement of worn disks with new disks is avoided, and data loss is reduced.

Abstract: Embodiments of the present disclosure provide a method for managing a storage system, an apparatus and a computer readable storage medium. The method comprises: determining a permitted concurrency number for respective access to multiple storage devices in the storage system by a multi-level cache device of the storage system, the permitted concurrency number being associated with a state of the multiple storage devices; in response to receiving an access request for the storage system, determining a cache device in the multi-level cache device corresponding to the access request; determining whether a current concurrency number of access to the multiple storage devices in the cache device reaches the permitted concurrency number; and in response to determining that the current concurrency number fails to reach the permitted concurrency number, executing the access request for the storage system.

Abstract: Embodiments of the present disclosure provide a method for establishing a multi-tier flash cache using spare drives. In some embodiments, there is provided a computer-implemented method, comprising: in response to receiving an I/O request, determining whether there is a free page in a main cache; in response to determining that there is no free page in the main cache, establishing a secondary cache by selecting at least one spare drive from spare drives; flushing data from a cold page in the main cache to the secondary cache, an access frequency of the cold page being lower than a predetermined threshold; and writing data related to the I/O request from a persistent storage device to the cold page.