Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A cosmetic product system is provided which includes a cosmetic composition for combating signs of aging, and a test device packaged with the composition. The device includes a mechanism for evaluating progress of the combat against the signs of aging occurring over a period of time within which the composition is applied to an area of skin being monitored.

Abstract: A process and equipment for manufacture of a swab article is provided wherein a stick is placed onto a conveyor, adhesive is applied to one or both ends of the stick, a portion of cotton coil is attached to the adhesive bearing end, and a shaper bar or similar means forces the cotton to assume a teardrop profile by applying force parallel to the stick, wherein the shaper bar or similar means moves in a direction perpendicular to the stick at a different rate of speed than that of the stick. Differences in the rate of speed reduce tailing of cotton normally associated with drag.

Abstract: A wipe article is provided for cleansing and providing gentle exfoliation. The article is a water-insoluble substrate laden with a fluid cosmetic composition that includes a skin benefit agent delivered in a carrier. The substrate is a woven or non-woven fibrous web with first and second major surfaces, at least one of the major surfaces having formed thereon an array of projections, the array including from at least 2 to about 20 projections per cm2. Each projection is formed of a material different than that of the substrate and is raised from the substrate at a highest point thereof a distance from 100 to 2,000 micron. The projections are formed of at least 20 microbeads per projection.