Abstract: Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

Abstract: Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

Abstract: Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.

Abstract: Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.

Abstract: Polyketal polymers, and methods of making and using such polyketal polymers are disclosed herein. The polyketal poylmers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the polyketal polymers are biodegradable.

Abstract: A modified push-pull booster circuit is proposed, wherein two alternately switching transistors are disposed on the primary winding of a transformer, and a bridge rectifier and a charging circuit are disposed on the secondary winding; wherein the bridge rectifier has a pair of inductors with inductive coupling installed on the first half and second half of the circuit. The push-pull circuit uses series inductance to step up the bus voltage, and, because of the degaussing effect when current is induced on the inductors, the inductance of the inductor can be decreased even without using snubber circuit, thus decreasing the peak voltage of the bridge rectifier, and balancing the magnitude of current flow in the secondary winding. By reducing the turn ratio on the transformer windings, the operating efficiency of the booster circuit can be considerably improved.

Abstract: A modified push-pull booster circuit is proposed, wherein two alternately switching transistors are disposed on the primary winding of a transformer, and a bridge rectifier and a charging circuit are disposed on the secondary winding; wherein the bridge rectifier has a pair of inductors with inductive coupling installed on the first half and second half of the circuit. The push-pull circuit uses series inductance to step up the bus voltage, and, because of the degaussing effect when current is induced on the inductors, the inductance of the inductor can be decreased even without using snubber circuit, thus decreasing the peak voltage of the bridge rectifier, and balancing the magnitude of current flow in the secondary winding. By reducing the turn ratio on the transformer windings, the operating efficiency of the booster circuit can be considerably improved.