Patents by Inventor Lian Mo
Lian Mo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11390591Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.Type: GrantFiled: February 26, 2020Date of Patent: July 19, 2022Assignee: Aluda Pharmaceuticals, Inc.Inventors: Qizheng Yao, Jianping Wu, Ruihuan Chen, Lei Zhang, Shining Yao, Lian Mo, Qingqing Zhang
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Publication number: 20200190042Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.Type: ApplicationFiled: February 26, 2020Publication date: June 18, 2020Inventors: QIZHENG YAO, JIANPING WU, RUIHUAN CHEN, LEI ZHANG, SHINING YAO, LIAN MO, QINGQING ZHANG
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Patent number: 10611736Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.Type: GrantFiled: May 11, 2017Date of Patent: April 7, 2020Assignee: Aluda Pharmaceuticals, Inc.Inventors: Qizheng Yao, Jianping Wu, Ruihuan Chen, Lei Zhang, Shining Yao, Lian Mo, Qingqing Zhang
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Publication number: 20190144399Abstract: The present invention provides a 2,4,6-trisubstituted s-triazine compound represented by general formula (I) or pharmaceutically acceptable salts, prodrugs or solvates thereof, a preparation method therefor, and use of these compounds in preparing drugs for preventing or treating diseases associated with protein kinase and vimentin dysregulation, and cell vacuolization, and in particular, drugs for treating or preventing cancer growth and metastasis, tissue fibrosis and atherosclerosis.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Inventors: QIZHENG YAO, JIANPING WU, RUIHUAN CHEN, LEI ZHANG, SHINING YAO, LIAN MO, QINGQING ZHANG
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Publication number: 20150231115Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: May 4, 2015Publication date: August 20, 2015Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, JR.
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Patent number: 9023885Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: GrantFiled: March 8, 2013Date of Patent: May 5, 2015Assignee: Natrogen Therapeutics International, Inc.Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, Jr.
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Patent number: 8563525Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount less than sufficient to inhibit CDKs.Type: GrantFiled: December 20, 2010Date of Patent: October 22, 2013Assignee: Natrogen Therapeutics International, Inc.Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, Jr.
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Publication number: 20130261025Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.Type: ApplicationFiled: August 2, 2012Publication date: October 3, 2013Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
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Patent number: 8394847Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: GrantFiled: August 26, 2009Date of Patent: March 12, 2013Assignee: Natrogen Therapeutics International, Inc.Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, Jr.
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Patent number: 8257923Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.Type: GrantFiled: January 4, 2011Date of Patent: September 4, 2012Assignee: Genetech, Inc.Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
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Publication number: 20110177504Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.Type: ApplicationFiled: January 4, 2011Publication date: July 21, 2011Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
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Publication number: 20110160157Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA in an amount less than sufficient to inhibit CDKs.Type: ApplicationFiled: December 20, 2010Publication date: June 30, 2011Applicant: NATROGEN THERAPEUTICS INTERNATIONAL, INC.Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, JR.
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Patent number: 7875431Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.Type: GrantFiled: February 22, 2008Date of Patent: January 25, 2011Assignee: Genentech, Inc.Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
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Publication number: 20090325895Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: August 26, 2009Publication date: December 31, 2009Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, JR.
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Patent number: 7582670Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: GrantFiled: April 13, 2005Date of Patent: September 1, 2009Assignee: Natrogen Therapeutics, Inc.Inventors: Longgui Wang, Xiao Mei Liu, Lian Mo, Simon K. Mencher, James P. McCarron, Jr.
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Publication number: 20090111102Abstract: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.Type: ApplicationFiled: February 22, 2008Publication date: April 30, 2009Applicant: Genentech, Inc.Inventors: Lauri Diehl, Kenneth Flanagan, Lian Mo
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Publication number: 20050197381Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: April 13, 2005Publication date: September 8, 2005Inventors: Longgui Wang, Xiao Liu, Lian Mo, Simon Mencher, James McCarron
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Publication number: 20050154046Abstract: The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: January 12, 2004Publication date: July 14, 2005Inventors: Longgui Wang, Xiao Liu, Lian Mo, Simon Mencher, James McCarron