Patent number: 11685761
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Type:
Grant
Filed:
December 17, 2018
Date of Patent:
June 27, 2023
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Brian M. Andresen, Frank Bennett, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Jongwon Lim, Min Lu, Benjamin Wesley Trotter, Wen-Lian Wu
Patent number: 11466047
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Type:
Grant
Filed:
May 7, 2018
Date of Patent:
October 11, 2022
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Wen-Lian Wu, Jongwon Lim, Jared N. Cumming, Benjamin Wesley Trotter, Wonsuk Chang
Publication number: 20210206796
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Type:
Application
Filed:
December 17, 2018
Publication date:
July 8, 2021
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Brian M. Andresen, Frank Bennett, Wonsuk Chang, Matthew Lloyd Childers, Jared N. Cumming, Jongwon Lim, Min Lu, Benjamin Wesley Trotter, Wen-Lian Wu
Publication number: 20200062798
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Type:
Application
Filed:
May 7, 2018
Publication date:
February 27, 2020
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Wen-Lian WU, Jongwon LIM, Jared N. Cumming, Benjamin Wesley TROTTER, Wonsuk CHANG