Patents by Inventor Liana Salsini

Liana Salsini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydrated and anhydrous polymorphs of 2?-O- fucosyllactose and their production methods
    Patent number: 11414449
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: August 16, 2022
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Hydrated and anhydrous polymorphs of 2'-O-fucosyllactose and their production methods
    Patent number: 10988499
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 27, 2021
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Hydrated and anhydrous polymorphs of 2?-O-fucosyllactose and their production methods
    Patent number: 10851128
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-0-ficosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: December 1, 2020
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • HYDRATED AND ANHYDROUS POLYMORPHS OF 2'-O-FUCOSYLLACTOSE AND THEIR PRODUCTION METHODS
    Publication number: 20200048295
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • HYDRATED AND ANHYDROUS POLYMORPHS OF 2'-O-FUCOSYLLACTOSE AND THEIR PRODUCTION METHODS
    Publication number: 20200048294
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-0-ficosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • HYDRATED AND ANHYDROUS POLYMORPHS OF 2'-O-FUCOSYLLACTOSE AND THEIR PRODUCTION METHODS
    Publication number: 20190284219
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: May 14, 2019
    Publication date: September 19, 2019
    Inventors: Giovanni CIPOLLETTI, Gessica LAUDATI, Liana SALSINI
  • Hydrated and anhydrous polymorphs of 2?-O-fucosyllactose and their production methods
    Patent number: 10308675
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-0-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: June 4, 2019
    Assignee: Inalco S.A.S. Di Giovanni Cipolletti & C.
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini
  • HYDRATED AND ANHYDROUS POLYMORPHS OF 2'-O-FUCOSSYLLACTOSE AND THEIR PRODUCTION METHODS
    Publication number: 20160060283
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2 H2O, Polymorph B 2 TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: July 12, 2013
    Publication date: March 3, 2016
    Inventors: Giovanni CIPOLLETTI, Gessica LAUDATI, Liana SALSINI
  • 6?-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides
    Patent number: 9034844
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 19, 2015
    Assignee: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • 6'-SIALYLLACTOSE SALTS AND PROCESS FOR THEIR SYNTHESIS AND FOR THE SYNTHESIS OF OTHER ALPHA-SIALYLOLIGOSACCHARIDES
    Publication number: 20120071441
    Abstract: The present invention relates to a process of synthesis of ?-sialyl oligosaccharides and in particular of 6?-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
    Type: Application
    Filed: April 6, 2010
    Publication date: March 22, 2012
    Applicant: INALCO S.P.A.
    Inventors: Giancarlo Tamerlani, Ilaria Lombardi, Debora Bartalucci, Andrea Danesi, Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • PROCESS FOR THE SYNTHESIS OF L-FUCOSYL DI- OR OLIGO-SACCHARIDES AND NOVEL 2,3,4 TRIBENZYL-FUCOSYL DERIVATIVES INTERMEDIATES THEREOF
    Publication number: 20110245488
    Abstract: The present invention relates to a process for the synthesis of L-fucosyl di- or oligosaccharides and their novel 2,3,4-tri-O-benzyl-fucosyl synthetic intermediates derivatives of easy crystallization. In particular the present invention relates to a process applicable to industrial scale for the synthesis of 2?O-fucosyl lactose.
    Type: Application
    Filed: December 18, 2009
    Publication date: October 6, 2011
    Applicant: INALCO S.P.A.
    Inventors: Liana Salsini, Marco Manoni, Giovanni Cipolletti
  • Polysaccharide derivatives with high antithrombotic activity in plasma
    Patent number: 7687249
    Abstract: The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: March 30, 2010
    Assignee: Inalco S.p.A.
    Inventors: Marco Manoni, Liana Salsini, Jacopo Chini, Giovanni Cipolletti
  • Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
    Patent number: 7361745
    Abstract: Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activity
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: April 22, 2008
    Assignee: Inalco S.p.A.
    Inventors: Giancarlo Tamerlani, Debora Bartalucci, Liana Salsini, Silvia Rapaccini
  • Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
    Publication number: 20070083041
    Abstract: Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing nucleotides of the L series having antiviral activity.
    Type: Application
    Filed: November 10, 2004
    Publication date: April 12, 2007
    Inventors: Giancarlo Tamerlani, Debora Bartalucci, Liana Salsini, Silvia Rapaccini
  • Polysaccharides derivatives with high antithrombotic activity in plasma
    Publication number: 20070042993
    Abstract: The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N-acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-0-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both 0-sulphations (0-sulphation and 60-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-Ila activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.
    Type: Application
    Filed: July 7, 2004
    Publication date: February 22, 2007
    Inventors: Marco Manoni, Liana Salsini, Jacopo Chini, Giovanni Cipolletti
  • Process for the preparation of ribofuranose derivatives
    Patent number: 6891036
    Abstract: The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): useful in the synthesis of nucleotides.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: May 10, 2005
    Assignee: Inalco S.p.A.
    Inventors: Giancarlo Tamerlani, Liana Salsini, Ilaria Lombardi, Debora Bartalucci, Giovanni Cipolletti
  • Process for the preparation of ribofuranose derivatives
    Publication number: 20040158059
    Abstract: The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): 1
    Type: Application
    Filed: May 27, 2003
    Publication date: August 12, 2004
    Inventors: Giancarlo Tamerlani, Liana Salsini, Ilaria Lombardi, Debora Bartalucci, Giovanni Cipolletti