Patents by Inventor Liane Chen

Liane Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenovirus vectors generated from helper viruses and helper-dependent vectors
    Patent number: 6566128
    Abstract: The present invention provides an improved helper-dependent vector system for production of high capacity adenoviral cloning vectors. The invention makes use of the DNA size packaging constraints imposed on a pIX-defective Ad virion that prevent such virions from packaging DNA larger than approximately 35 kb. This constraint can be used to develop helper viruses that do not package their DNA. In one embodiment, the invention combines this methodology with the Cre-loxP helper-dependent system to decrease the quantity of contaminating helper virus in vector preparations. In another embodiment the invention is used for vector growth.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: May 20, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Frank L. Graham, Robin Parks, Liane Chen
  • Adenovirus vectors generated from helper viruses and helper-dependent vectors
    Patent number: 6080569
    Abstract: The present invention provides an improved helper-dependent vector system for production of high capacity adenoviral cloning vectors. The invention makes use of the DNA size packaging constraints imposed on a pIX-defective Ad virion that prevent such virions from packaging DNA larger than approximately 35 kb. This constraint can be used to develop helper viruses that do not package their DNA. In one embodiment, the invention combines this methodology with the Cre-loxP helper-dependent system to decrease the quantity of contaminating helper virus in vector preparations. In another embodiment the invention is used for vector growth.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: June 27, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Frank L. Graham, Robin Parks, Liane Chen