Patents by Inventor Lianfa SHI

Lianfa SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetra-specific, octameric binding agents and antibodies against toxin A and toxin B for treatment of infection
    Patent number: 10961299
    Abstract: Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 30, 2021
    Assignee: University of Maryland, Baltimore
    Inventors: Hanping Feng, Yongjun Guan, Yongrong Zhang, Zhiyong Yang, Lianfa Shi
  • TETRA-SPECIFIC, OCTAMERIC BINDING AGENTS AND ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXIN A AND TOXIN B FOR TREATMENT OF C. DIFFICILE INFECTION
    Publication number: 20180244760
    Abstract: Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 30, 2018
    Applicant: University of Maryland, Baltimore
    Inventors: Hanping FENG, Yongjun GUAN, Yongrong ZHANG, Zhiyong YANG, Lianfa SHI