Abstract: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

Abstract: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

Abstract: A backlight module including a frame, a light guide, at least one reflective cover and at least one light source is provided. The frame includes an upper frame having at least one first fastener thereon and a lower frame having at least one second fastener thereon. The light guide is disposed inside the frame and has at least one light incident surface and a light emitting surface. The reflective cover is placed inside the frame at one side of the frame. The reflective cover has at least one third fastener and at least one fourth fastener thereon, wherein the third fastener and the first fastener of the upper frame are fastened together while the fourth fastener and the second fastener of the lower frame are fastened together. The light source is disposed between the light incident surface of the light guide and the reflective cover.

Abstract: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

Abstract: A MOSFET structure and a method of forming it are described. The thickness of a portion of the gate dielectric layer of the MOSFET structure adjacent to the drain region is increased to form a bird's beak structure. The gate-to-drain overlap capacitance is reduced by the bird's beak structure.

Abstract: This invention describes a method for storing and searching sets of e-mail data by classification so as to effectively organize mass quantities of e-mail data and to improve the searching and reading efficiency of e-mail reading programs. This method produces an electronic book from such data as well as produces chapter directories of different categories accordingly so that the user can read the content of his e-mail as if he's reading a book. The method of this invention involves first retrieving the e-mail of a specified period from an e-mail server or an e-mail file and then classifying the e-mail into different categories according to the attributes or contents thereof so as to enable the categories to be converted into the chapter directories of the electronic book and mapped to the actual content of the e-mail.

Abstract: An apparatus for projecting computer generated stereoscopic images, comprising: a computer, a dual-port video signal output device, two image projection devices, an image projection software and a stereoscopic image file, wherein the stereoscopic image file is processed and outputted to the two image projection devices through the cooperating operation of the computer, the dual-port video signal output device and the image projection software, so that a stereo image can be projected.

Abstract: A semiconductor package substrate is provided having a plurality of bonding pads on at least one surface thereof and covered by a conductive film. A photoresist layer formed over the conductive film has a plurality of first openings for exposing portions of the conductive film corresponding to the bonding pads. The exposed portions of the conductive film is removed to expose the bonding pads respectively via the first openings. The exposed bonding pads are plated with a metal layer respectively. Then, the photoresist layer and the remainder of the conductive film covered by the photoresist layer are removed. A solder mask having a plurality of second openings may be formed on the surface of the substrate, and allows the plated metal layer on the bonding pads respectively to be exposed via the second openings.

Abstract: An engaging structure of a backlight module is disclosed. The engaging structure utilizes protruding portions, which extend from the bottom edge of a side wall of a mold frame, insert into corresponding holes on a chassis, and so fasten and position the mold frame on the chassis. The engaging structure prevents that the problems of light leak are caused by the backlight module and scratches on a driving IC on a side of a backlight.

Abstract: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NF?B activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NF?B transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.

Abstract: A method of plating a metal layer over isolated pads on a semiconductor package substrate is proposed. This substrate is formed with a plurality of conductive blind vias. The isolated pads are formed on a surface of the substrate, each having a plating line extending towards one blind via but electrically insulated from the blind via by an electrically insulating region. A conductive film covers the surface of the substrate having the isolated pads, and a photoresist layer is formed over the conductive film. The photoresist layer has openings for exposing a portion of the conductive film covering the isolated pads. The exposed portion of the conductive film is removed, to allow a metal layer to be plated on the isolated pads. Then, the photoresist layer and the remainder of the conductive film are removed, and the electrical insulation between the isolated pads and the blind vias is restored.

Abstract: A MOSFET structure and a method of forming it are described. The thickness of a portion of the gate dielectric layer of the MOSFET structure adjacent to the drain region is increased to form a bird's beak structure. The gate-to-drain overlap capacitance is reduced by the bird's beak structure.

Abstract: The present invention relates to improved methods for the treatment or prevention of disease with gene therapy or vaccines comprising host optimized GM-CSF nucleic acid sequences. More particularly, the invention provides methods for codon optimized GM-CSF with enhanced expression and adjuvant activity ex vivo and in vivo. The present invention also provides for methods of optimizing homologous gene expression ex vivo and in vitro or in transgenic animals.

Abstract: A method of plating a metal layer over isolated pads on a semiconductor package substrate is proposed. This substrate is formed with a plurality of conductive blind vias. The isolated pads are formed on a surface of the substrate, each having a plating line extending towards one blind via but electrically insulated from the blind via by an electrically insulating region. A conductive film covers the surface of the substrate having the isolated pads, and a photoresist layer is formed over the conductive film. The photoresist layer has openings for exposing a portion of the conductive film covering the isolated pads. The exposed portion of the conductive film is removed, to allow a metal layer to be plated on the isolated pads. Then, the photoresist layer and the remainder of the conductive film are removed, and the electrical insulation between the isolated pads and the blind vias is restored.

Abstract: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFkB activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFkB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.

Abstract: The present invention relates to methods of using compositions for stimulate an immunological response against cancer. The method comprising contacting colloidal metal with a tumor cell in an aqueous solution to form a colloidal metal-protein complex, separating the colloidal metal-protein complex from other cellular components, and administering a therapeutically effective amount of the colloidal metal-protein complexes to a tumor-bearing subject. The present invention further relates to a composition which is made by contacting colloidal metal with a cell in an aqueous solution to form a colloidal metal-protein complex, and separating the colloidal metal-protein complex from other cellular components.

Abstract: An optical module is composed of three light-guide units and a holder for the units. Each of the light-guide units is made of a mirror plane used for reflecting and transmitting light installed between two prisms via the use of circularly applied glue. The holder includes three installation areas one installation area for each light-guide unit. Additionally, the holder has two frames that are arranged perpendicularly to each other and each frame is installed perpendicularly to the joining sides of two installation areas i.e. one frame is installed perpendicular to the side where installation area 1 and installation area 2 meet and the other frame is installed perpendicular to the side where installation area 2 and installation area 3 meet.

Abstract: A semiconductor package substrate is provided having a plurality of bonding pads on at least one surface thereof and covered by a conductive film. A photoresist layer formed over the conductive film has a plurality of first openings for exposing portions of the conductive film corresponding to the bonding pads. The exposed portions of the conductive film is removed to expose the bonding pads respectively via the first openings. The exposed bonding pads are plated with a metal layer respectively. Then, the photoresist layer and the remainder of the conductive film covered by the photoresist layer are removed. A solder mask having a plurality of second openings may be formed on the surface of the substrate, and allows the plated metal layer on the bonding pads respectively to be exposed via the second openings.

Abstract: The present invention relates to improved methods for the treatment or prevention of disease with gene therapy or vaccines comprising host optimized GM-CSF nucleic acid sequences. More particularly, the invention provides methods for codon optimized GM-CSF with enhanced expression and adjuvant activity ex vivo and in vivo. The present invention also provides for methods of optimizing homologous gene expression ex vivo and in vitro or in transgenic animals.

Abstract: Cell transfection compositions including an amphipathic compound and an enzyme inhibitor such as a histone deacetylase inhibitor for delivery of genetic material into cells are provided. The cell transfection compositions can express high levels of an encoding protein with minium cytotoxicity. Exemplary histone deacetylase inhibitors include trichostatin A (TSA), FR901464, FR901228, trapoxin A (TPX). The amphipathic compounds can be cationic compounds, neutral compounds or combinations thereof. The enzyme inhibitor can be encapsulated in a liposome formed by the amphipathic compound or the enzyme inhibitor can be mixed with a pre-formed liposome of the amphipathic compound.