Patents by Inventor Liang Du

Liang Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250043307
    Abstract: An expression cassette containing overlapping open reading frames and an application thereof are provided. The overlapping open reading frames are overlapping open reading frames of a first ORF and a second ORF and include in sequence from a 5? end to a 3? end: a first promoter at least used to drive gene transcription of the first ORF; a 5? part of a gene of the first ORF; an intron; and a 3? part of a gene of the second ORF, the intron including a second promoter used only to drive gene transcription of the second ORF. By arranging two promoters in a single expression cassette in the disclosure, the two promoters are used to drive the expression of proteins of the overlapping reading frames and regulate the relative expression time and expression intensity of different proteins.
    Type: Application
    Filed: February 6, 2024
    Publication date: February 6, 2025
    Applicant: GENEVOYAGER (WUHAN) CO., LTD.
    Inventors: He XIAO, Xiaobin HE, Gang HUANG, Xing PAN, Yicheng ZHOU, Liang DU, Mengdie WANG, Huanhuan ZUO, Hao SUN
  • Patent number: 12215581
    Abstract: A fracturing apparatus includes a motor, a first plunger pump, a power supply platform, a gas turbine engine, a generator, and one or more rectifiers. At least two of the gas turbine engine, the generator, and the one or more rectifiers are arranged on the power supply platform. A first end of the generator is connected to the gas turbine engine. A second end of the generator is connected to the one or more rectifiers. The generator is configured to output a voltage to the one or more rectifiers. The one or more rectifiers are configured to provide power to the motor. The motor is configured to drive the first plunger pump.
    Type: Grant
    Filed: May 2, 2023
    Date of Patent: February 4, 2025
    Assignee: YANTAI JEREH PETROLEUM EQUIPMENT & TECHNOLOGIES CO., LTD.
    Inventors: Shuzhen Cui, Rikui Zhang, Dong Liu, Jifeng Zhong, Liang Lv, Xincheng Li, Sheng Chang, Chunqiang Lan, Jian Zhang, Xiaolei Ji, Huaizhi Zhang, Ruijie Du, Dawei Zhao, Shouzhe Li
  • Patent number: 12218890
    Abstract: The present disclosure relates to methods and systems for sharing with a plurality of users a chat session that uses large language models to provide responses for input messages received for the chat session. The methods and systems provide access to the chat session to the users and update the chat session in response to any changes made to the chat session by any of the users. The methods and systems allow the users to resume the chat session at a future time using the chat session history.
    Type: Grant
    Filed: October 19, 2023
    Date of Patent: February 4, 2025
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Robin Abraham, Liang Du, Manqing Mao, Paishun Ting, Julia Chen, Jianzhe Lin, Yijian Xiang, Mingyang Xu, Wenhan Wang, Fahimeh Raja
  • Patent number: 12191004
    Abstract: This disclosure describes a machine learning system that includes a contrastive learning based two-tower model for retrieval of relevant chemical reaction procedures given a query chemical reaction. The two-tower model uses attention-based transformers and neural networks to convert tokenized representations of chemical reactions and chemical reaction procedures to embeddings in a shared embedding space. Each tower can include a transformer network, a pooling layer, a normalization layer, and a neural network. The model is trained with labeled data pairs that include a chemical reaction and the text of a chemical reaction procedure for that chemical reaction. New queries can locate chemical reaction procedures for performing a given chemical reaction as well as procedures for similar chemical reactions. The architecture and training of the model make it possible to perform semantic matching based on chemical structures. The model is highly accurate providing an average recall at K=5 of 95.9%.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: January 7, 2025
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Sudipto Mukherjee, Liang Du, Ke Jiang, Robin Abraham
  • Publication number: 20240428008
    Abstract: The present disclosure relates to methods and systems for using large language models to support research activities. The methods and systems include a copilot engine that creates input prompts to provide to the large language model to use in generating responses to input messages. The copilot engine infers an intent of the input messages and sends the intent with the input message in the input prompt to the large language model. The large language model generates different types of responses for different intents.
    Type: Application
    Filed: June 22, 2023
    Publication date: December 26, 2024
    Inventors: Robin ABRAHAM, Liang DU, Fahimeh RAJA, Wenhan WANG, Dustin James STEWART, Lipsa PATNAIK, Stuart Richard LONG, Timothy EARNHEART, Sam Daniel GAMMON, Sacha AROZARENA VALLADARE, Jedediah Miller SINGER, Henrique DANTAS
  • Publication number: 20240430216
    Abstract: The present disclosure relates to methods and systems for sharing with a plurality of users a chat session that uses large language models to provide responses for input messages received for the chat session. The methods and systems provide access to the chat session to the users and update the chat session in response to any changes made to the chat session by any of the users. The methods and systems allow the users to resume the chat session at a future time using the chat session history.
    Type: Application
    Filed: October 19, 2023
    Publication date: December 26, 2024
    Inventors: Robin ABRAHAM, Liang DU, Manqing MAO, Paishun TING, Julia CHEN, Jianzhe LIN, Yijian XIANG, Mingyang XU, Wenhan WANG, Fahimeh RAJA
  • Publication number: 20240428005
    Abstract: The present disclosure relates to methods and systems for automatically generating documents for a specific topic using large language models. The methods and systems receive an input query that identifies a topic for the document. The methods and systems automatically generate, using the large language models, a framework for the document with sections and subsections for the document. The methods and systems write the document, using the large language models, and provide references for the data sources used to obtain the data that the large language model used to write the document.
    Type: Application
    Filed: June 20, 2023
    Publication date: December 26, 2024
    Inventors: Robin ABRAHAM, Mingyang XU, Julia CHEN, Yijian XIANG, Manqing MAO, Jianzhe LIN, Paishun TING, Liang DU
  • Patent number: 12169680
    Abstract: The present disclosure relates to methods and systems for converting Portable Document Format (PDF) documents to LaTeX files. The methods and systems use machine learning models to identify and extract PDF portions of a PDF document. The methods and systems create a LaTeX file for the PDF document using the PDF portions extracted by the machine learning models. The methods and systems provide an output with the LaTeX file for the PDF document. The LaTeX file is used to perform different actions on the PDF document.
    Type: Grant
    Filed: June 6, 2022
    Date of Patent: December 17, 2024
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Harsh Shrivastava, Sarah Panda, Liang Du, Robin Abraham
  • Patent number: 12159722
    Abstract: A relevance system ranks a set of medical studies based on a relevance of each medical study in the set of medical studies to a patient profile. The relevance system includes a relevance model. The relevance model determines a relevance of each medical study to the patient profile based on a semantic relationship score, a concept relationship score, and a term-occurrence score. The semantic relationship score is a measure of a similarity in semantic meaning of a medical study and a patient profile. The concept relationship score is a measure of the closeness of medical concepts in a medical study to medical concepts in a patient profile. The term-occurrence score is a measure of occurrences of terms in a medical study that also appear in a patient profile and the statistical significances of the terms.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: December 3, 2024
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Nut Limsopatham, Liang Du, Robin Abraham
  • Publication number: 20240296294
    Abstract: Disclosed are techniques for an AI system with a large language mode (LLM) with improved accuracy and reliability in solving mathematical problems. An initial query is transformed into a template query by replacing the original input values with variables. Multiple prompts are sent to the LLM, each being different from one another, and contextually related to the template query. Multiple results are responsively received from the LLM, each result including an analytical expression to solve the mathematical problem. Each of the expressions is evaluated using a numerical evaluation tool with variables of the expression being assigned a common set of randomly sampled values. A consensus is achieved when the evaluated expressions satisfy a consensus condition, such as when all outputs match consistently over N experiments or trials. After the consensus condition is reached, the original inputs are evaluated with one or more of the expressions, and the solution is output.
    Type: Application
    Filed: May 8, 2023
    Publication date: September 5, 2024
    Inventors: Shima IMANI, Harsh SHRIVASTAVA, Liang DU
  • Patent number: 12072935
    Abstract: Machine learning to predict a layout type that each of a plurality of portions of a document appears in. This is done even though the computer-readable representation of the document does not contain information at the granularity of the prediction to be made that identifies which layout type that each of the plurality of document portions belongs in. For each of a plurality of the portions, the machine-learning system predicts the layout type that the respective portion appears in, and indexes the document using the predictions so as to result in a computer-readable index. The index represents a predicted layout type associated with each of the plurality of portions of the document. Thus, the index can be used to search based on position of a searched term within the document.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: August 27, 2024
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Yao Li, Liang Du, Robin Abraham
  • Publication number: 20240247282
    Abstract: The disclosure discloses an expression cassette for expressing a gene including overlapping open reading frames in an insect cell and an application thereof. The expression cassette includes from 5? to 3? and operably linked: a promoter capable of driving transcription in the insect cell; an artificially constructed sequence; the overlapping open reading frames missing only a first translation start codon; wherein the artificially constructed sequence includes a native or engineered intron with splicing activity in the insect cell, the intron includes ATG or the intron is located between any two adjacent nucleotides in ATG. A recombinant adeno-associated virus vector including the expression cassette of the disclosure regulates relative expressions of VP1, VP2, and VP3 proteins, and relative expressions of Rep78 and Rep52 proteins by using a designed intron sequence and through an intron splicing function for large-scale production of rAAV.
    Type: Application
    Filed: September 27, 2021
    Publication date: July 25, 2024
    Applicant: GENEVOYAGER (WUHAN) CO., LTD.
    Inventors: He XIAO, Xiaobin HE, Gang HUANG, Ying HU, Xing PAN, He HUANG, Liang DU, Mengdie WANG
  • Patent number: 12025007
    Abstract: A coal uncovering construction method for blasting large cross-section gas tunnels includes: analyzing stress distribution characteristics in front of a tunnel boring working face, and then determining a thickness calculation model of a reserved rock wall based on a limit equilibrium theory; establishing a tunnel model, simulating a construction condition and analyzing a construction result, and determining a thickness of the reserved rock wall; and fixing a detonator through a fixed sand ring, fitting the detonator with a construction hole by adjusting an adjustable protective plate, then embedding the detonator into a blast hole, and blasting the detonator for tunnel construction. Furthermore, an extension ring is fixed between the fixed sand ring and the adjustable protective plate.
    Type: Grant
    Filed: July 21, 2023
    Date of Patent: July 2, 2024
    Assignees: China Railway 16th Bureau Group Co., Lid, China Railway Eryuan Engineering Group Co, Eid, Beijing Jiaotong University, China Railway 16th Bureau Group 1st Engineering Co., Ltd, China Railway 16th Bureau Group 4th Engineering Co., Ltd
    Inventors: Wuxian Wang, Su Yan, Liang Kuang, Jinwen Yang, Mingli Huang, Yitao Feng, Wanqiang Zhao, Liujie Jin, Weiming Zhang, Qian Dong, Liang Du
  • Patent number: 12018860
    Abstract: An integrated pressure condensing boiler is provided which relates to the technical field of boilers. The integrated pressure condensing boiler includes a pressure-bearing housing, a heat-exchange furnace arranged in the pressure-bearing housing, a combustion chamber communicating with the heat-exchange furnace and cooling tube groups fixed in the heat-exchange furnace. Heat-exchange medium flows from bottom to top in the pressure-bearing housing and in the cooling tube groups, and exchanges heat with high-temperature flue gas flowing from top to bottom in the heat-exchange furnace, thus achieving a counterflow heat exchanging. The heat-exchange furnace includes a multi-stage heat-exchange chamber with each heat-exchange chamber being cylindrical. The heat-exchange chambers are arranged in sequence from top to bottom to achieve a flue gas diffusing manner that high-temperature flue gas diffuses from center part to periphery and then gathers from periphery to center part.
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: June 25, 2024
    Assignee: Langfang Jinhua Boiler Co., Ltd.
    Inventors: Guoling Ye, Xijun Zhang, Hui Ye, Qing Ye, Bing Zhang, Xin Zhao, Guolei Wang, Weidong Yao, Jianzhong Wu, Yimin Wu, Liang Du
  • Publication number: 20240193440
    Abstract: The present disclosure relates to utilizing a dynamic knowledge graph enrichment system to dynamically and automatically maintain knowledge graphs shared between groups of user identifiers with up-to-date findings and discoveries. In particular, the dynamic knowledge graph enrichment system changes static shared knowledge graphs into dynamically evolving ones utilizing statistical guarantees that automatically incorporate new edge connections into a shared knowledge graph after verifying the reliability and veracity of the proposed edge connections being offered. Further, the dynamic knowledge graph enrichment system facilitates forming new connections between different shared knowledge graphs that previously went undetected by flexibly facilitating exploration over multiple knowledge graphs and providing synergistic knowledge graph updates.
    Type: Application
    Filed: December 12, 2022
    Publication date: June 13, 2024
    Inventors: Harsh SHRIVASTAVA, Sarah PANDA, Liang DU
  • Patent number: 12009635
    Abstract: A method (600) for tuning a tunable laser (310) includes delivering a bias current (IDBR) to an anode of a distributed Bragg reflector (DBR) section diode (D2) disposed on a shared substrate of the tunable laser and receiving a burst mode signal (440) indicative of a burst-on state or a burst-off state. When the burst mode signal is indicative of the burst-off state, the method includes offsetting the bias current at the anode of the DBR section diode by one of sourcing a push current with the bias current to the anode of the DBR section diode or sinking a pull current away from the bias current at the anode of the DBR section diode. When the burst mode signal is indicative of the burst-on state, the method also includes ceasing any offsetting of the bias current at the anode of the DBR section diode.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: June 11, 2024
    Assignee: Google LLC
    Inventors: Tao Zhang, Cedric Fung Lam, Xiangjun Zhao, Shuang Yin, Liang Du, Changhong Joy Jiang, Adam Edwin Taylor Ward Barratt, Claudio Desanti, Muthu Nagarajan
  • Publication number: 20240150455
    Abstract: Provided are an anti-CLDN6 antibody or an antigen-binding fragment thereof; a nucleic acid molecule encoding same; an immunoconjugate, a bispecific molecule, a chimeric antigen receptor and a pharmaceutical composition containing same; and the use thereof for preventing and/or treating tumors.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 9, 2024
    Inventors: Liang Du, Hongyan Zhang, Lina Jin, Yali Chen, Tingting Wan, Liuliu Xu, Jijun Yuan
  • Patent number: 11977634
    Abstract: The disclosure discloses a method for detecting an intrusion in parallel based on an unbalanced data Deep Belief Network, which reads an unbalanced data set DS; under-samples the unbalanced data set using the improved NCR algorithm to reduce the ratio of the majority type samples and make the data distribution of the data set balanced; the improved differential evolution algorithm is used on the distributed memory computing platform Spark to optimize the parameters of the deep belief network model to obtain the optimal model parameters; extract the feature of data of the data set, and then classify the intrusion detection by the weighted nuclear extreme learning machine, and finally train multiple weighted nuclear extreme learning machines of different structures in parallel by multithreading as the base classifier, and establish a multi-classifier intrusion detection model based on adaptive weighted voting for detecting the intrusion in parallel.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: May 7, 2024
    Assignee: HUNAN UNIVERSITY
    Inventors: Kenli Li, Zhuo Tang, Qing Liao, Chubo Liu, Xu Zhou, Siyang Yu, Liang Du
  • Publication number: 20240087683
    Abstract: A machine learning model trained with a triplet loss function classifies input strings into one of multiple hierarchical categories. The machine learning model is pre-trained using masking language modeling on a corpus of unlabeled strings. The machine learning module includes an attention-based bi-directional transformer layer. Following initial training, the machine learning model is refined by additional training with a loss function that includes cross-entropy loss and triplet loss. This provides a deep learning solution to classify input strings into one or more hierarchical categories. Embeddings generated from inputs to the machine learning model capture language similarities that can be visualized in a cartesian plane where strings with similar meanings are grouped together.
    Type: Application
    Filed: September 14, 2022
    Publication date: March 14, 2024
    Inventors: Pramod Kumar SHARMA, Andy Daniel MARTINEZ, Liang DU, Robin ABRAHAM, Saurabh Chandrakant THAKUR
  • Patent number: 11907164
    Abstract: This application relates to a file loading method performed at an electronic device, and a non-transitory computer-readable storage medium thereof. The method including: receiving, in response to a user operation, an instruction for loading a target file; determining an associated feature of at least one piece of resource information in the target file; determining a type of the resource information according to the associated feature of the resource information; and loading the resource information by using a loading algorithm corresponding to the type of the resource information.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: February 20, 2024
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventor: Liang Du