Abstract: Provided are an anti-CLDN6 antibody or an antigen-binding fragment thereof; a nucleic acid molecule encoding same; an immunoconjugate, a bispecific molecule, a chimeric antigen receptor and a pharmaceutical composition containing same; and the use thereof for preventing and/or treating tumors.

Abstract: A device includes a voltage regulator circuit configured to pull up a voltage at an output terminal to equal to half of a supply voltage; multiple first transistors coupled between the output terminal and a voltage terminal providing the supply voltage; and a control circuit configured to pull down gate voltages of the first transistors from the supply voltage to a voltage level between the supply voltage and a ground voltage at a first time. The first transistors are configured to pull up the voltage at the output terminal to the supply voltage at a second time.

Abstract: A cross-coupling control method for moving beam of gantry machine tool is disclosed, which relates to the technical field of CNC machine tool control. The cross-coupling control method includes: Step 1: establishing a crossbeam dynamics model considering a ram on the crossbeam, and at the same time simplifying the model for an observer design; step 2: realizing a PID control parameter adjustment of motors at both ends in accordance with a method of parameter tuning of a unilateral servo control system; using a servo system with the same control parameters to jointly drive the crossbeam up and down, realizing the synchronous control and realizing PID control parameter tuning for both end motors. The disclosure not only reduces the synchronization error caused by the torsion of the crossbeam, but also solves the synchronization error caused by the asymmetric load on both sides, and improves the system robustness and stability.

Abstract: The application belongs to the field of big data, and particularly relates to an official document processing method, device, computer equipment and storage medium. The method includes the following steps of: performing format analysis on the to-be-reviewed official document, then acquiring the to-be-reviewed official document of standard file type, and identifying all file components and contents in the to-be-reviewed official document of standard file type; performing text format detection, text content detection and frame layout detection synchronously by a preset text processing model, obtaining a format detection result, a content detection result and a layout detection result; generating a detected error content according to the format detection result, content detection result and layout detection result, calling out a standard writing rule corresponding to the detected error content, marking the detected error content and the standard writing rule in the to-be-reviewed official document.

Abstract: An artificial heart valve prosthesis includes a stent comprising at least two commissures spaced circumferentially around the stent, the commissure provided with a first window and a second window, which are arranged along an axial direction of the stent, the first window located closer to an outflow end of the stent; and at least two leaflets arranged circumferentially around the stent, each of the leaflets including a main segment and flaps arranged on opposite circumferential sides of the main segment, the main segment disposed on an inner side of the stent, the flap passed through the second window and covering at least a part of an outer surface of the commissure, the flap sutured at the first window and the second window.

Abstract: Disclosed are a person Re-identification (Re-ID) method, system, and device, and a computer-readable storage medium. The method includes: acquiring a sample set to be trained (S101); training a pre-constructed person Re-ID model by data re-sampling and cross-validation methods based on the sample set to be trained to obtain a trained person Re-ID model (S102); and performing person Re-ID based on the trained person Re-ID model, wherein persons in any two groups are of different classes after the sample set to be trained is grouped according to the cross-validation method (S103).

Abstract: The present application discloses a 3D printing device and a release method and a liquid containing mechanism therefor, and relates to the field of 3D printing. The liquid containing mechanism comprises a material box foundation, a material box and a plurality of motion guide components. The material box foundation is a rigid annular plate with a mounting groove and is detachably mounted on a base of the 3D printing device, the mounting groove of the material box foundation is covered by a light-transmitting glass plate, and the glass plate is fixed on an upper surface of the material box foundation. The plurality of motion guide components are fixed to a peripheral edge of the material box and then detachably fixed on the material box foundation. Each of the motion guide components is a following component with an upper limit structure and a lower limit structure, and the following component is fixed to the peripheral edge of the material box.

Abstract: A use of micro- and nano-MgH2 compound particles in the inhibition of Leishmania infection and in the treatment of Leishmaniasis is provided. The micro- and nano-MgH2 compound particles can be used to prepare a pharmaceutical composition for inhibiting Leishmania or to prepare a pharmaceutical composition for treating a skin or mucosal ulcer or visceral damage caused by Leishmania infection. The present disclosure discovers for the first time that the micro- and nano-MgH2 compound particles can significantly reduce the number of Leishmania in macrophages and inhibit the proliferation of Leishmania, indicating a very prominent insecticidal inhibition effect. The micro- and nano-MgH2 compound particles of the present disclosure can quickly and effectively cure a skin ulcer and/or a mucosal ulcer caused by Leishmania and an impaired function of an internal organ (mainly liver and spleen) caused by Leishmania and have high biosafety and huge clinical application values.

Abstract: Provided are a system for constructing a genome-wide sgRNA library and a use thereof. The system includes an input module, an sgRNA design module and an sgRNA filtering module. By constructing three modules in the system, optimizing details and processes in the modules, and adopting multiple design criteria and screening principles, the genome-wide sgRNA library is finally constructed. The system and method are concise and efficient, and the obtained library has a high quality and good activity, and is convenient for applications in gene editing researches.

Abstract: The disclosed technology addresses the problem of testing performance of RU scheduling algorithms used by an OFDMA enabled AP to support multiple clients, using a two-armed test harness with a wired connection to one side of an AP under test and multiple wireless clients coupled in RF communication with the AP. The wireless clients can be connected over the air or conductively to antenna(s) of the AP under test. The test harness generates test traffic. A sniffer radio listens to RU allocation and schedules traffic broadcast by the AP to multiple clients. A recording module records the RU allocation and traffic and a report generator categorizes the recorded resource allocation with the scheduling traffic heard by the sniffer radio and provides resource allocation statistics. The wireless clients are connected conductively or OTA to antennas of the AP under test. One sniffer radio replaces multiple sniffers used in prior test systems.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

Abstract: A device includes a voltage regulator circuit, a power switch circuit, and a control circuit. The voltage regulator circuit generates an output voltage at an output terminal. The power switch circuit is coupled to the voltage regulator circuit. The control circuit receives a first control signal and generates a second control signal that includes a first portion gradually declining between a first time and a second time later than the first time. When the voltage regulator circuit is turned off and a logic state of the first control signal changes at the first time, the power switch circuit is turned on at the second time, in response to the second control signal, to adjust the output voltage.

Abstract: A method of tracking a source display panel from which an illegal copy of an image is captured by a camera is provided. The method includes generating a content image visible to human eyes using a visible light component integrated in an integrated light emitting source; generating a watermark image invisible to the human eyes in real time using an invisible light component integrated in the same integrated light emitting source; and simultaneously displaying the content image and the watermark image on the source display panel. Generating the watermark image includes generating an image of an identifier unique to the source display panel. The method further includes analyzing the image captured by the camera to extract the image of an identifier unique to the source display panel; and identifying the source display panel based on the identifier unique to the source display panel.

Abstract: A device includes a voltage regulator circuit, a power switch circuit, and a control circuit. The voltage regulator circuit generates an output voltage at an output terminal. The power switch circuit is coupled to the voltage regulator circuit. The control circuit receives a first control signal and generates a second signal that includes a first portion gradually declining between a first time and a second time later than the first time. When the voltage regulator circuit is turned off and a logic state of the first control signal changes at the first time, the power switch circuit is turned on at the second time, in response to the second control signal, to adjust the output voltage.

Abstract: The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Abstract: In an example embodiment, a process may calculate a fill ratio for each element in the background mesh. The process may identify partially filled elements of the background mesh based on the calculated fill ratios. The process may transform each partially filled element to an empty or filled element by identifying a node of the partially filled element and moving the identified node to a different location in the background mesh. The process may generate an updated background mesh, that includes only empty and filled elements, that may be utilized to perform one or more calculations for one or more time steps in a modeling/simulation environment to simulate a behavior of a physical material/object that may exhibit deformations.

Abstract: A method of tracking a source display panel from which an illegal copy of an image is captured by a camera is provided. The method includes generating a content image visible to human eyes using a visible light component integrated in an integrated light emitting source; generating a watermark image invisible to the human eyes in real time using an invisible light component integrated in the same integrated light emitting source; and simultaneously displaying the content image and the watermark image on the source display panel. Generating the watermark image includes generating an image of an identifier unique to the source display panel. The method further includes analyzing the image captured by the camera to extract the image of an identifier unique to the source display panel; and identifying the source display panel based on the identifier unique to the source display panel.

Abstract: The disclosed technology addresses the problem of testing performance of RU scheduling algorithms used by an OFDMA enabled AP to support multiple clients, using a two-armed test harness with a wired connection to one side of an AP under test and multiple wireless clients coupled in RF communication with the AP. The wireless clients can be connected over the air or conductively to antenna(s) of the AP under test. The test harness generates test traffic. A sniffer radio listens to RU allocation and schedules traffic broadcast by the AP to multiple clients. A recording module records the RU allocation and traffic and a report generator categorizes the recorded resource allocation with the scheduling traffic heard by the sniffer radio and provides resource allocation statistics. The wireless clients are connected conductively or OTA to antennas of the AP under test. One sniffer radio replaces multiple sniffers used in prior test systems.

Abstract: The present application discloses a 3D printing device and a release method and a liquid containing mechanism therefor, and relates to the field of 3D printing. The liquid containing mechanism comprises a material box foundation, a material box and a plurality of motion guide components. The material box foundation is a rigid annular plate with a mounting groove and is detachably mounted on a base of the 3D printing device, the mounting groove of the material box foundation is covered by a light-transmitting glass plate, and the glass plate is fixed on an upper surface of the material box foundation. The plurality of motion guide components are fixed to a peripheral edge of the material box and then detachably fixed on the material box foundation. Each of the motion guide components is a following component with an upper limit structure and a lower limit structure, and the following component is fixed to the peripheral edge of the material box.