Abstract: The present disclosure relates to the field of data processing. Provided is a distributed computing method, comprising: acquiring a data computing task; splitting the data computing task to obtain subtasks, deploying the subtasks to computing nodes, and configuring a parallel mode for each of the computing nodes in a distributed training universal frame; configuring a connection manner and a communication synchronization manner between the computing nodes; optimizing information synchronization efficiency for the computing nodes by using a gradient optimization algorithm or a non-gradient optimization algorithm; and aggregating intermediate results generated by the computing nodes, and outputting a corresponding final computing result.

Abstract: An image generating method and apparatus, and a device and a medium are disclosed. The method comprises: acquiring weakly correlated image-text data pairs, and creating an image-text data set according to the weakly correlated image-text data pairs, wherein the weakly correlated image-text data pairs are image-text data pairs in which images and texts have weak correlations (S11); training, by using the image-text data set, an image generation model which is preconstructed on the basis of an adversarial network, so as to obtain a trained image generation model, wherein the image generation model includes a generator for generating an image, and a discriminator for identifying the authenticity of the image and calculating a corresponding loss value (S12); and after when text data to be processed has been acquired, generating, by using the trained image generation model, an image corresponding to the said text data (S13).

Abstract: In one embodiment, a technique for numerical integration in material point method (MPM)-based geotechnical analysis and simulation is provided. Input terms for an element of a background mesh are received. The input terms including material points in the element that describe a continuum of soil, rock and/or groundwater. A set of constraints is created that defines an optimization problem. The set of constraints provide that numerical integration of the material points weighted by unknown integration weights equal exact integration for finite element shape functions. The optimization problem defined by the constraints is solved by an optimization algorithm to minimize numerical integration error for polynomials up to a given order to produce a set of integration weights. The set of integration weights is scaled to conserve the mass of the material points to produce optimized integration weights.

Abstract: The present invention discloses the use of flibanserin in the preparation of a drug for treating androgenic alopecia. The results of cell models show that flibanserin at a low concentration can inhibit the proliferation of Lncap cells, showing a pharmacodynamic activity at the cellular level. The results of animal experiments show that flibanserin can reverse androgen-mediated androgenic alopecia damage, treat androgenic alopecia and restore hair growth. Therefore, flibanserin can be used in the preparation of a drug for treating androgenic alopecia.

Abstract: The present invention discloses the use of flibanserin in the preparation of a drug for treating androgenic alopecia. The results of cell models show that flibanserin at a low concentration can inhibit the proliferation of Lncap cells, showing a pharmacodynamic activity at the cellular level. The results of animal experiments show that flibanserin can reverse androgen-mediated androgenic alopecia damage, treat androgenic alopecia and restore hair growth. Therefore, flibanserin can be used in the preparation of a drug for treating androgenic alopecia.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

Abstract: Methods of scintillation, scintillation devices, and metal halide hybrids that may be used as X-ray scintillators. The metal halide hybrids may include organic metal halide hybrids, inorganic metal halide hybrids, or organic-inorganic metal halide hybrids. The metal halide hybrids may have a 0D structure. The metal halide hybrids may be in the form of one or more discrete crystals.

Abstract: In one embodiment, material points are received that cover at least a portion of an element of a background mesh that describes a continuum of soil, rock and/or groundwater. MPM-based geotechnical analysis and simulation is conducted at least in part by performing a numerical integration over the material points to produce a system matrix and right-hand side vector. The numerical integration applies hierarchical shape functions to the material points. The MPM-based geotechnical analysis and simulation also may subtract out contributions of any lower-order polynomials from higher-order polynomials of the hierarchical shape functions when interpolating one or more state variables for the material points to the background mesh. The MPM-based geotechnical analysis and simulation also may subtract out contributions any lower-order polynomials from higher-order polynomials of the hierarchical shape functions when calculating one or more boundary conditions for the material points.

Abstract: A method and apparatus for allocating a computing task of a neural network in heterogeneous resources, a computer device, and a storage medium. The method includes: acquiring task information of the computing task of the neural network and resource information of the heterogeneous resources; determining, according to the task information and the resource information, an allocation mode for allocating each subtask to the heterogeneous resources for execution and a task processing cost corresponding to each allocation mode; constructing a directed acyclic graph according to each allocation mode and each task processing cost; obtaining a value of a loss function corresponding to each allocation path according to the task processing cost corresponding to each subtask in an allocation path of the directed acyclic graph; and selecting a target allocation path according to the value of each loss function.

Abstract: The present invention relates to the technical field of antibody drugs, and particularly relates to an anti-TIGIT antibody or antigen-binding fragment thereof, an anti-TIGIT/anti-PD-L1 antibody or antigen-binding fragment thereof, and pharmaceutical compositions containing an anti-TIGIT antibody or antigen-binding fragment thereof or an anti-TIGIT/anti-PD-L1 antibody or antigen-binding fragment thereof, and applications thereof. The anti-TIGIT/anti-PD-L1 antibody of the present invention has significant antitumor activity, and can be applied in the preparation of antitumor drugs.

Abstract: A device includes a voltage regulator circuit configured to pull up a voltage at an output terminal to equal to half of a supply voltage; multiple first transistors coupled between the output terminal and a voltage terminal providing the supply voltage; and a control circuit configured to pull down gate voltages of the first transistors from the supply voltage to a voltage level between the supply voltage and a ground voltage at a first time. The first transistors are configured to pull up the voltage at the output terminal to the supply voltage at a second time.

Abstract: A method for forming a power module package includes providing a power module including an electrical element and an electrical connection portion; providing an electrical connection terminal including a connection end, an extension portion and an end cap, wherein the extension portion is extended between the connection end and the end cap and has a hollow cavity therein; disposing the electrical connection terminal on the electrical connection portion for electrically connecting the connection end to a corresponding electrical connection portion; packaging the power module and the electrical connection terminal through an encapsulant to form a packaged body; removing a portion of a surface of the packaged body for exposing the end cap of the electrical connection terminal; and removing the end cap to expose the hollow cavity of the electrical connection terminal, so as to form the power module package.

Abstract: The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Abstract: A device includes a voltage regulator circuit configured to pull up a voltage at an output terminal to equal to half of a supply voltage; multiple first transistors coupled between the output terminal and a voltage terminal providing the supply voltage; and a control circuit configured to pull down gate voltages of the first transistors from the supply voltage to a voltage level between the supply voltage and a ground voltage at a first time. The first transistors are configured to pull up the voltage at the output terminal to the supply voltage at a second time.

Abstract: An artificial heart valve prosthesis includes a stent comprising at least two commissures spaced circumferentially around the stent, the commissure provided with a first window and a second window, which are arranged along an axial direction of the stent, the first window located closer to an outflow end of the stent; and at least two leaflets arranged circumferentially around the stent, each of the leaflets including a main segment and flaps arranged on opposite circumferential sides of the main segment, the main segment disposed on an inner side of the stent, the flap passed through the second window and covering at least a part of an outer surface of the commissure, the flap sutured at the first window and the second window.

Abstract: Disclosed are a person Re-identification (Re-ID) method, system, and device, and a computer-readable storage medium. The method includes: acquiring a sample set to be trained (S101); training a pre-constructed person Re-ID model by data re-sampling and cross-validation methods based on the sample set to be trained to obtain a trained person Re-ID model (S102); and performing person Re-ID based on the trained person Re-ID model, wherein persons in any two groups are of different classes after the sample set to be trained is grouped according to the cross-validation method (S103).

Abstract: The present application discloses a 3D printing device and a release method and a liquid containing mechanism therefor, and relates to the field of 3D printing. The liquid containing mechanism comprises a material box foundation, a material box and a plurality of motion guide components. The material box foundation is a rigid annular plate with a mounting groove and is detachably mounted on a base of the 3D printing device, the mounting groove of the material box foundation is covered by a light-transmitting glass plate, and the glass plate is fixed on an upper surface of the material box foundation. The plurality of motion guide components are fixed to a peripheral edge of the material box and then detachably fixed on the material box foundation. Each of the motion guide components is a following component with an upper limit structure and a lower limit structure, and the following component is fixed to the peripheral edge of the material box.

Abstract: A use of micro- and nano-MgH2 compound particles in the inhibition of Leishmania infection and in the treatment of Leishmaniasis is provided. The micro- and nano-MgH2 compound particles can be used to prepare a pharmaceutical composition for inhibiting Leishmania or to prepare a pharmaceutical composition for treating a skin or mucosal ulcer or visceral damage caused by Leishmania infection. The present disclosure discovers for the first time that the micro- and nano-MgH2 compound particles can significantly reduce the number of Leishmania in macrophages and inhibit the proliferation of Leishmania, indicating a very prominent insecticidal inhibition effect. The micro- and nano-MgH2 compound particles of the present disclosure can quickly and effectively cure a skin ulcer and/or a mucosal ulcer caused by Leishmania and an impaired function of an internal organ (mainly liver and spleen) caused by Leishmania and have high biosafety and huge clinical application values.

Abstract: Provided are a system for constructing a genome-wide sgRNA library and a use thereof. The system includes an input module, an sgRNA design module and an sgRNA filtering module. By constructing three modules in the system, optimizing details and processes in the modules, and adopting multiple design criteria and screening principles, the genome-wide sgRNA library is finally constructed. The system and method are concise and efficient, and the obtained library has a high quality and good activity, and is convenient for applications in gene editing researches.

Abstract: The disclosed technology addresses the problem of testing performance of RU scheduling algorithms used by an OFDMA enabled AP to support multiple clients, using a two-armed test harness with a wired connection to one side of an AP under test and multiple wireless clients coupled in RF communication with the AP. The wireless clients can be connected over the air or conductively to antenna(s) of the AP under test. The test harness generates test traffic. A sniffer radio listens to RU allocation and schedules traffic broadcast by the AP to multiple clients. A recording module records the RU allocation and traffic and a report generator categorizes the recorded resource allocation with the scheduling traffic heard by the sniffer radio and provides resource allocation statistics. The wireless clients are connected conductively or OTA to antennas of the AP under test. One sniffer radio replaces multiple sniffers used in prior test systems.