Patents by Inventor Liang Qiang

Liang Qiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blood-brain barrier comprising engineered endothelial cells
    Patent number: 11786559
    Abstract: The present invention relates, in part, to blood-brain barrier-like tissues that comprise engineered E40RF1+ endothelial cells, and to various compositions and methods useful for making and using such blood-brain barrier-like tissues—both in vitro and in vivo.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: October 17, 2023
    Inventors: Michael Daniel Ginsberg, Daniel Joseph Nolan, Liang Qiang
  • BLOOD-BRAIN BARRIER COMPRISING ENGINEERED ENDOTHELIAL CELLS
    Publication number: 20210283188
    Abstract: The present invention relates, in part, to blood-brain barrier-like tissues that comprise engineered E40RF1+ endothelial cells, and to various compositions and methods useful for making and using such blood-brain barrier-like tissues—both in vitro and in vivo.
    Type: Application
    Filed: September 13, 2017
    Publication date: September 16, 2021
    Inventors: Michael Daniel Ginsberg, Daniel Joseph Nolan, Liang Qiang
  • Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
    Patent number: 10947500
    Abstract: In certain aspects the present invention provides engineered neural cells, neural stem cells, or neural progenitor cells that contain a nucleotide sequence that encodes an adenovirus E40RF1 polypeptide and/or that contain an adenovirus E40RF1 polypeptide. The present invention also provides methods of making and using such engineered cells and compositions comprising such engineered cells.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: March 16, 2021
    Inventors: Liang Qiang, Daniel Joseph Nolan, Claude Geoffrey Davis
  • COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL CORD INJURY
    Publication number: 20210030810
    Abstract: The present invention provides methods for treating spinal cord injury (SCI). Such methods involve administering E40RF1+ endothelial cells and neural cells (such as neural progenitor cells (NPCs), glial progenitor cells, or glial cells) to subjects having a SCI. The present invention also provides compositions useful in such methods, such as compositions comprising E40RF1+ endothelial cells and/or neural cells (such as NPCs, glial progenitor cells, or glial cells).
    Type: Application
    Filed: January 22, 2019
    Publication date: February 4, 2021
    Inventors: Daniel Joseph Nolan, Michael Aron Lane, Liang Qiang, Lyandysha Viktorovna Zholudeva
  • NEURAL CELLS EXPRESSING ADENOVIRUS E4ORF1, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20170137781
    Abstract: In certain aspects the present invention provides engineered neural cells, neural stem cells, or neural progenitor cells that contain a nucleotide sequence that encodes an adenovirus E40RF1 polypeptide and/or that contain an adenovirus E40RF1 polypeptide. The present invention also provides methods of making and using such engineered cells and compositions comprising such engineered cells.
    Type: Application
    Filed: June 26, 2015
    Publication date: May 18, 2017
    Inventors: Liang Qiang, Daniel Joseph Nolan, Claude Geoffrey Davis
  • HUMAN INDUCED NEURONAL CELLS
    Publication number: 20140193341
    Abstract: A method for reprogramming a fibroblast into a human induced neuronal cell (hIN) is described. The method comprises expressing heterologous reprogramming factors Bm2, Myt11, Zic1, Olig2, Asc11 or any combination thereof, in said fibroblast, and culturing the fibroblast in a medium comprising BDNF, NT3, GeM or any combination thereof. Biomarkers describing the obtained hiN cells are also presented. In another aspect, methods for screening compounds using the hiN cells is described.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 10, 2014
    Inventors: Asa Abeliovich, Liang Qiang