Patents by Inventor Liang Shan
Liang Shan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10463028Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.Type: GrantFiled: May 18, 2015Date of Patent: November 5, 2019Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)Inventors: Andrew J. Murphy, Sean Stevens, Richard Flavell, Markus Gabriel Manz, Liang Shan
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Patent number: 10225949Abstract: A method for controlling the rotational speed of a fan of an LED lamp, comprising: presetting a corresponding relationship between a voltage, a current and a temperature for an LED chip in the LED lamp in the controller, as well as presetting a corresponding relationship between the temperature of LED chip and the speed of the fan in the controller, measuring the voltage and current of the LED chip, obtaining the current calculated temperature of the LED chip through the measured voltage and current, and further determining the current desired fan speed through the obtained current calculated temperature, using the controller to control the fan to rotate at the current desired speed, thereby cooling the LED chip. Additionally a corresponding system for controlling the rotational speed of the fan of an LED lamp and an LED lamp including the system.Type: GrantFiled: December 6, 2017Date of Patent: March 5, 2019Assignee: GE Lighting Solutions, LLCInventors: Min Fang, Qi Long, Liang Shan, Shuyi Qin, Yong Li
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Patent number: 10123518Abstract: Genetically modified non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.Type: GrantFiled: April 12, 2016Date of Patent: November 13, 2018Assignees: Regeneron Pharmaceuticals, Inc, Yale University, Institute For Research In Biomedicine (IRB)Inventors: Dietmar Herndler-Brandstetter, Richard A. Flavell, Davor Frleta, Cagan Gurer, Markus Gabriel Manz, Andrew J. Murphy, Noah W. Palm, Liang Shan, Sean Stevens, Till Strowig, George D. Yancopoulos, Marcel de Zoete
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Publication number: 20180295820Abstract: Genetically modified non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.Type: ApplicationFiled: April 16, 2018Publication date: October 18, 2018Inventors: Dietmar Herndler-Brandstetter, Richard A. Flavell, Davor Frleta, Cagan Gurer, Markus Gabriel Manz, Andrew J. Murphy, Noah W. Palm, Liang Shan, Sean Stevens, Till Strowig, George D. Yancopoulos, Marcel de Zoete
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Publication number: 20180160564Abstract: A method for controlling the rotational speed of a fan of an LED lamp, comprising: presetting a corresponding relationship between a voltage, a current and a temperature for an LED chip in the LED lamp in the controller, as well as presetting a corresponding relationship between the temperature of LED chip and the speed of the fan in the controller, measuring the voltage and current of the LED chip, obtaining the current calculated temperature of the LED chip through the measured voltage and current, and further determining the current desired fan speed through the obtained current calculated temperature, using the controller to control the fan to rotate at the current desired speed, thereby cooling the LED chip. Additionally a corresponding system for controlling the rotational speed of the fan of an LED lamp and an LED lamp including the system.Type: ApplicationFiled: December 6, 2017Publication date: June 7, 2018Inventors: Min FANG, Qi LONG, Liang SHAN, Shuyi QIN, Yong LI
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Publication number: 20170360920Abstract: Described herein are methods of preventing or treating a HIV infection comprising administering to a mammal in need thereof, a pharmaceutically effective amount of a CD8+ T cell vaccine composition. Such methods comprising using CD8+ T cells which have been pre-stimulated with at least one HIV epitope, to thereby enhance a CD8+ T cell immune response against HIV in said mammal.Type: ApplicationFiled: November 20, 2015Publication date: December 21, 2017Inventors: Robert Siliciano, Kai Deng, Liang Shan
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Publication number: 20170274001Abstract: The invention relates generally to a composition and method for increasing the frequency, amount, or presence of red blood cells in peripheral blood. In one embodiment, the invention comprises the inhibition of, or genetic modification of the genes encoding, one or more scavenger receptors. In one aspect, the invention relates to treatments of anemia.Type: ApplicationFiled: September 8, 2015Publication date: September 28, 2017Inventors: Richard Flavell, Liang Shan
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Publication number: 20160295844Abstract: Genetically modified non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRP? and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.Type: ApplicationFiled: April 12, 2016Publication date: October 13, 2016Inventors: Dietmar Herndler-Brandstetter, Richard A. Flavell, Davor Frleta, Cagan Gurer, Markus Gabriel Manz, Andrew J. Murphy, Noah W. Palm, Liang Shan, Sean Stevens, Till Strowig, George D. Yancopoulos, Marcel de Zoete
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Publication number: 20150327524Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.Type: ApplicationFiled: May 18, 2015Publication date: November 19, 2015Inventors: Andrew J. Murphy, Sean Stevens, Richard Flavell, Markus Gabriel Manz, Liang Shan
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Patent number: 8971929Abstract: The disclosure discloses a method and a system for transmitting location data. The method comprises at least one step of that: the location data is transmitted between a first terminal and a second terminal; the location data is transmitted between a first location server and a second location server; and the location data is transmitted between a third terminal and a third location server, wherein the location data comprises: assistance location data and/or position data. According to the technical solution provided by the disclosure, the location function between two terminals supporting Security User Plane Location (SUPL) can be realized, and some novel assistance location data can be transmitted.Type: GrantFiled: March 25, 2011Date of Patent: March 3, 2015Assignee: ZTE CorporationInventors: Hui Li, Liang Shan
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Patent number: 8965396Abstract: This document discusses a location system, method, server and terminal. A location information server provides a Secure User Plane for Location, SUPL, Enabled Terminal, SET, with location information regarding the SET in a form of reference; the SET provides a Secure User Plane for Location, SUPL, server with the location information reference regarding the SET via an SUPL message; the SUPL server obtains the location information regarding the SET from the location information server according to the location information reference transmitted by the SET.Type: GrantFiled: March 24, 2010Date of Patent: February 24, 2015Assignee: ZTE CorporationInventors: Hui Li, Liang Shan
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Patent number: 8744409Abstract: A method for locating a Secure User Plane Location (SUPL) Enabled Terminal (SET) is provided by the present invention. The method includes that: the SET obtaining the location service information of the local access network when accessing the local access network, wherein the location service information includes the address and/or identification of at least one of the location server in the local access network; the SET transmitting the location service information of the local access network to the Home SUPL Location Platform (H-SLP) of the SET; and the SET receiving the location service information transmitted by the H-SLP, wherein the location service information includes the address and/or identification of the location server providing the location service for the SET in the local access network. An SET and an H-SLP are also provided by the present invention.Type: GrantFiled: March 25, 2011Date of Patent: June 3, 2014Assignee: ZTE CorporationInventors: Hui Li, Liang Shan
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Publication number: 20130017844Abstract: The disclosure discloses a method and a system for transmitting location data. The method comprises at least one step of that: the location data is transmitted between a first terminal and a second terminal; the location data is transmitted between a first location server and a second location server; and the location data is transmitted between a third terminal and a third location server, wherein the location data comprises: assistance location data and/or position data. According to the technical solution provided by the disclosure, the location function between two terminals supporting Security User Plane Location (SUPL) can be realized, and some novel assistance location data can be transmitted.Type: ApplicationFiled: March 25, 2011Publication date: January 17, 2013Applicant: ZTE CorporationInventors: Hui Li, Liang Shan
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Publication number: 20130012166Abstract: A method for locating a Secure User Plane Location (SUPL) Enabled Terminal (SET) is provided by the present invention. The method includes that: the SET obtaining the location service information of the local access network when accessing the local access network, wherein the location service information includes the address and/or identification of at least one of the location server in the local access network; the SET transmitting the location service information of the local access network to the Home SUPL Location Platform (H-SLP) of the SET; and the SET receiving the location service information transmitted by the H-SLP, wherein the location service information includes the address and/or identification of the location server providing the location service for the SET in the local access network. An SET and an H-SLP are also provided by the present invention.Type: ApplicationFiled: March 25, 2011Publication date: January 10, 2013Applicant: ZTE CORPORATIONInventors: Hui Li, Liang Shan
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Publication number: 20120184293Abstract: The present disclosure discloses a location system, method, server and terminal. In the scheme of the present disclosure, a location information server provides a Secure User Plane for Location (SUPL) Enabled Terminal (SET) with location information regarding the SET in a form of reference; the SET provides a Secure User Plane for Location (SUPL) server with location information corresponding to the location information reference regarding the SET; the SUPL server obtains the location information regarding the SET for the location information server according to the location information reference transmitted by the SET, to enable the convergence of the mainstream location architecture based on the SUPL of Open Mobile Architecture (OMA) Location (LOC) group and another mainstream location architecture based on the Location Configuration Protocol (LCP) of the Internet Engineering Task Force (IETF).Type: ApplicationFiled: March 24, 2010Publication date: July 19, 2012Applicant: ZTE CORPORATIONInventors: Hui Li, Liang Shan
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Publication number: 20120126718Abstract: An inspection fixture for inspecting an LED array of a circuit board under test through a power supply unit, includes: an inspection base having a testing platform with a plurality of pairs of anode and cathode probes corresponding to anode and cathode pins of the LEDs of the LED array, each pair being electrically connected to the power supply unit to constitute a power supply circuit; a carrier board used for carrying the circuit board under test and having through holes corresponding to the anode and cathode probes; and a pressing member for pressing the circuit board and driving the carrier board to move so as to enable the anode and cathode probes to pass through the through holes and come into contact with the anode and cathode pins of the LEDs, thereby supplying power to each of the LEDs to emit light through the power supply circuit.Type: ApplicationFiled: December 7, 2010Publication date: May 24, 2012Applicant: Askey Computer CorporationInventors: Shi-Liang Shan, Xiao-Bo Zhu, Ching-Feng Hsieh