Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.

Abstract: This application provides a coverage hole detection method and a related device in the field of communication technologies. If a coverage hole exists between two access point (APs), a terminal passes through the coverage hole when roaming between the two APs. Therefore, a roaming behavior of the terminal between the APs can reflect whether the coverage hole exists between the APs. An electronic device determines, based on a roaming behavior of a terminal between a first AP and a second AP, that a coverage hole exists between the first AP and the second AP. The roaming behavior of the terminal between the first AP and the second AP includes roaming behaviors of a plurality of terminals between the first AP and the second AP.

Abstract: A networking method, a networking apparatus, an electronic device, and a storage medium, are disclosed. The electronic device obtains a networking requirement. The networking requirement includes a scene requirement, a coverage requirement, a device capability requirement, and a matching requirement between upstream and downstream devices. The electronic device obtains a networking structure based on the scene requirement, determines, based on the coverage requirement, the device capability requirement, and the matching requirement, a model of a device at each layer in the networking structure and a quantity corresponding to the model, and connects devices at two adjacent layers in the networking structure to generate a networking solution.

Abstract: According to embodiments of the present disclosure, there is provided a solution for medical data processing. In this solution, a first set of entities and a second set of entities are respectively extracted from a first medical report and a second medical report related to a patient. A semantic correlation is determined between the first set of entities and the second set of entities. A concordance level between medical information in the first medical report and medical information of the second medical report is determined based on the semantic correlation. In this way, the cross-report concordance analysis can be automatically conducted based on semantic correlation of entities extracted from the reports.

Abstract: Embodiments of this application disclose an interference source detection method, apparatus, device, and system, and a storage medium. The method includes: obtaining data detected by a plurality of access points (Aps), where data detected by any AP of the plurality of APs includes load information and radio frequency information of the any AP, received signal strength indicator RSSI information between the any AP and a neighbor of the any AP, and load information and radio frequency information of the neighbor of the any AP; determining a global neighbor topology based on the data detected by the plurality of APs; and determining an interference source based on the global neighbor topology.

Abstract: A power configuration method is disclosed, which pertains to the field of communication technologies. In the power configuration method, a power configuration of an AP is determined based on signal quality data of a STA, to ensure coverage experience of the AP. Real coverage experience of the AP may be further obtained based on the signal quality data of the STA, to further optimize the power configuration of the AP.

Abstract: In accordance with an embodiment, a device identification method includes: obtaining historical connection data of the second device belonging to a wireless local area network (WLAN), where the historical connection data reflects a connection status between each of at least one terminal device that used to be connected to the second device and the WLAN; and determining the second device as an edge wireless access point (AP) device based on off-net terminal device data of the second device.

Abstract: In accordance with an embodiment, a device identification method includes: obtaining historical connection data of the second device belonging to a wireless local area network (WLAN), where the historical connection data reflects a connection status between each of at least one terminal device that used to be connected to the second device and the WLAN; and determining the second device as an edge wireless access point (AP) device based on off-net terminal device data of the second device.

Abstract: The present disclosure relates to the technical field of nut-derived fruit oil preparation, in particular to a method for extracting palmitoleic acid from Macadamia integrifolia and use thereof. In the method for extracting palmitoleic acid from Macadamia integrifolia, a fruit oil of the Macadamia integrifolia is purified by vacuum distillation, and an antioxidant is added during the vacuum distillation. A preparation method of the antioxidant includes the following steps: extracting a pulverized Macadamia integrifolia green peel using ethanol by heat reflux to obtain a green peel extract; extracting the green peel extract using petroleum ether, and then using ethyl acetate; collecting an ethyl acetate layer to obtain the antioxidant. The method can avoid easy oxidization and deterioration of oil during extracting and enriching the palmitoleic acid, and can enrich the palmitoleic acid in the fruit oil of the Macadamia integrifolia by not less than 3 times.

Abstract: In the field of communication technologies or the field of artificial intelligence, a terminal scanning method, system, and apparatus, an electronic device, and a storage medium may be provided. In the method, an AP determines, based on communication feature information of a terminal that accesses the AP, whether a neighboring AP needs to scan the terminal; and if yes, the AP notifies the neighboring AP to scan the terminal. This reduces a quantity of times that the neighboring AP scans the terminal, and reduces calculation overheads of the neighboring AP.

Abstract: The invention provides a method for automatically filling a digital report form with relevant user data. The method includes obtaining a digital report form and extracting an input data model from the digital report form. A query is then generated based on the input data model. A digital user record is obtained, relevant user data is identified in the digital user record based on the query and extracted. The digital report form is then filled based on the relevant user data.

Abstract: A method for determining a terminal profile includes a data detector detecting one or more first terminals for a plurality of times to determine a plurality of groups of profile detection data. A data analyzer determines a reference terminal profile based on the plurality of groups of profile detection data. Different terminal profiles can be further determined for different category information to adapt to a category of the terminal.

Abstract: A Macadamia integrifolia whitening extract and a preparation method thereof are disclosed. The preparation method includes: S1: carrying out a hot extraction on a crushed Macadamia integrifolia green peel using an ethanol solution as an extraction solvent to obtain a crude green peel extract; then enzymatically treating the crude green peel extract using a snailase to obtain a enzymatic hydrolysate; finally extracting the enzymatic hydrolysate using a petroleum ether, and taking an aqueous phase to obtain a green peel extract; S2: carrying out a hot extraction on crushed Sichuan lovase rhizome decoction pieces using an ethanol solution as an extraction solvent to obtain a Sichuan lovase rhizome extract; S3: dispersing the green peel extract and the Sichuan lovase rhizome extract in water to obtain a whitening extract.

Abstract: The present disclosure relates to the technical field of nut-derived fruit oil preparation, in particular to a method for extracting palmitoleic acid from Macadamia integrifolia and use thereof. In the method for extracting palmitoleic acid from Macadamia integrifolia, a fruit oil of the Macadamia integrifolia is purified by vacuum distillation, and an antioxidant is added during the vacuum distillation. A preparation method of the antioxidant includes the following steps: extracting a pulverized Macadamia integrifolia green peel using ethanol by heat reflux to obtain a green peel extract; extracting the green peel extract using petroleum ether, and then using ethyl acetate; collecting an ethyl acetate layer to obtain the antioxidant. The method can avoid easy oxidization and deterioration of oil during extracting and enriching the palmitoleic acid, and can enrich the palmitoleic acid in the fruit oil of the Macadamia integrifolia by not less than 3 times.

Abstract: A Macadamia integrifolia whitening extract and a preparation method thereof are disclosed. The preparation method includes: S1: carrying out a hot extraction on a crushed Macadamia integrifolia green peel using an ethanol solution as an extraction solvent to obtain a crude green peel extract; then enzymatically treating the crude green peel extract using a snailase to obtain a enzymatic hydrolysate; finally extracting the enzymatic hydrolysate using a petroleum ether, and taking an aqueous phase to obtain a green peel extract; S2: carrying out a hot extraction on crushed Sichuan lovase rhizome decoction pieces using an ethanol solution as an extraction solvent to obtain a Sichuan lovase rhizome extract; S3: dispersing the green peel extract and the Sichuan lovase rhizome extract in water to obtain a whitening extract.

Abstract: Embodiments of this application disclose an interference source detection method, apparatus, device, and system, and a storage medium. The method includes: obtaining data detected by a plurality of access points (Aps), where data detected by any AP of the plurality of APs includes load information and radio frequency information of the any AP, received signal strength indicator RSSI information between the any AP and a neighbor of the any AP, and load information and radio frequency information of the neighbor of the any AP; determining a global neighbor topology based on the data detected by the plurality of APs; and determining an interference source based on the global neighbor topology.

Abstract: Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.

Abstract: The invention discloses an induced drilling method for inertial constraint implicated motion, which is characterized by comprising a motion step of separating weight on bit and torque. The induced drilling method of inertial constraint implicating motion comprises the following steps: step 1, model selection of induced drilling; step 2, potential energy storage of induced drilling, wherein step 2 includes: I, uniform cutting induced drilling under a steady condition; II, distribution of induced drilling shock wave propagation under a transient condition; III, potential energy release of torsion spring in induced drilling under the transient condition; IV, constrained buffer for induced drilling under transient conditions; and V, potential energy compensation for induced drilling under transient conditions. The invention also discloses an inertia constraint induced drilling device accompanying the PDC bit.

Abstract: Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.

Abstract: Disclosed herein are methods for the isolation and purification of a botulinum neurotoxin (BoNT) protein, or a polypeptide comprising a receptor binding domain of BoNT, from a solution. The method comprises contacting the solution containing the protein or polypeptide to a matrix which has attached thereto a non-toxic non-hemagglutinin (NTNHA) under conditions appropriate for binding, washing the matrix to thereby remove unbound materials, and eluting the protein or polypeptide with a solution that dissociates the bound protein from the NTNHA. Conditions appropriate for binding are a pH of less than 7.5 (e.g, 6). Conditions appropriate for dissociation are a pH greater than or equal to 7.5 (e.g., 8). Compositions specific to the methods are also disclosed.