Abstract: Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.

Abstract: Reactor configurations may include one or more staged inlets and/or one or more staged outlets for gaseous and solid feedstocks. In one embodiment of the present disclosure, a reactor design for gas-solid reaction with one or more additional outlet for gas and/or solid phase is provided. In yet another embodiment, the design for a gas-solid reactor with one side inlet and two outlets for gas phase is described. In one embodiment, a reactor design with pairs of inlet and outlet for both gas and solid phase is provided. In another embodiment, a reactor design with one or more side inlets but only one outlet for gas phase is provided. In yet another embodiment, a reactor design with two inlets at the top/bottom of reactor and two side outlets for gaseous phase is described. In yet another embodiment, a reactor design with one or more side inlets and outlets for both gas and solid phases is provided.

Abstract: Provided in the present application is a humanized and multifunctional CD3 antibody; a heavy chain variable region of the CD3 antibody comprised herein contains the amino acid sequence of any one of SEQ ID NOs: 1-3 or a variant sequence thereof; and a light chain variable region thereof contains the amino acid sequence of any one of SEQ ID NOs: 26-28 or a variant sequence thereof. Further provided in the present application is a multifunctional antibody comprising (a) a light chain-heavy chain pair that has specificity for tumor cells or microorganisms; and (b) a fusion peptide that comprises a single-chain variable fragment and an Fc fragment having a CH2 domain and/or a CH3 domain, the fusion peptide having specificity for immune cells. The antibodies provided in the present application have improved biological activity, thermal stability and/or acid resistance.

Abstract: The present invention relates to the technical field of lighting for plant, and in particular, provides a multi-reflection panel lamp. The multi-reflection panel lamp includes a fixing frame, a plurality of panel lamps, and a plurality of reflectors. The plurality of panel lamps are embedded in the fixing frame parallel to each other. The reflectors and the panel lamps are parallelly disposed on the fixing frame. Compared to other panel lamps, in the present invention, reflectors are disposed between panel lamps to reflect, a plurality of times by using a multi-refraction mechanism of the reflectors of the panel lamps, rays of light emitted by the panel lamps, so that plants are irradiated with the rays of light at various angles, thereby improving lighting intensity and uniformity and ensuring normal growth of the plants.

Abstract: The present invention relates to a bispecific antibody, which is a tetravalent symmetrical bispecific antibody with a structure of F(ab)2-(Fv)2-Fc and comprises two identical fusion heavy chains and two identical fusion light chains.

Abstract: The present application discloses a supported PtZn intermetallic alloy catalyst, a method for preparing the same and application thereof. The catalyst uses SiO2 as a support and Zn as a promoter, and a small amount of active component Pt is supported; the weight percentage of Pt is 0.025%-1%, and the weight percentage of Zn is 0.025%-1.7%, a co-impregnation method is adopted in preparation, the SiO2 support is impregnated in aqueous solution of chloroplatinic acid and zinc nitrate, and then drying and high-temperature reduction are performed to obtain a PtZn/SiO2 catalyst. The catalyst has the advantages of high activity, high stability, low price and low toxicity. The catalyst provided by the present application is applicable to preparation of alkene through short-chain alkane dehydrogenation, in particular to preparation of propylene through propane dehydrogenation in a hydrogen atmosphere.

Abstract: A radiator and a plant illumination lamp containing the radiator. The radiator includes a heat-radiating baseplate configured for fixing a heat source, and heat-radiating side plates connected to the heat-radiating baseplate. The heat-radiating side plates each are provided with a plurality of heat-exchanging through grooves running through the heat-radiating side plates. The heat-exchanging through groove forms a heat potential difference, so that under the influence of the heat potential difference, the cold air outside the radiator passes through the heat-exchanging through groove on the heat-radiating side plates, and then flows out through a hot air chamber and an air outlet at an upper end of the hot air chamber after exchanging heat with the heat-exchanging through groove on the heat-radiating side plates, so as to form a strong natural air convection.

Abstract: Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.

Abstract: A supported core-shell bimetallic catalyst with high selectivity, and preparation method and an application thereof are provided. SBA-15 is used as support, platinum (Pt) is used as active component, 3d transition metal is used as cocatalysts. In the core-shell bimetallic catalyst formed by the 3d transition metal and Pt, in one aspect, by the addition of the 3d metal in the core, the d-band center of surface Pt atoms is down shifted, and the absorption of propylene is weakened, thereby improving the selectivity for propylene. In another aspect, the use of Pt is reduced by the addition of the 3d transition metal, improving the utilization of Pt. The catalyst is applicable in a hydrogen atmosphere, has a good effect on the preparation of propylene by propane dehydrogenation and causes high dehydrogenation activity under high temperature conditions. The total selectivity for propylene may reach 85%, which achieves high propylene selectivity.

Abstract: Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.

Abstract: The present invention relates to the technical field of lighting for plant, and in particular, provides a multi-reflection panel lamp. The multi-reflection panel lamp includes a fixing frame, a plurality of panel lamps, and a plurality of reflectors. The plurality of panel lamps are embedded in the fixing frame parallel to each other. The reflectors and the panel lamps are parallelly disposed on the fixing frame. Compared to other panel lamps, in the present invention, reflectors are disposed between panel lamps to reflect, a plurality of times by using a multi-refraction mechanism of the reflectors of the panel lamps, rays of light emitted by the panel lamps, so that plants are irradiated with the rays of light at various angles, thereby improving lighting intensity and uniformity and ensuring normal growth of the plants.

Abstract: The present disclosure relates to a modified Fc fragment, antibodies containing the same and the use thereof. The Fc fragment is derived from human IgG1, and the constant region CH2 domain of the Fc fragment contains multiple substitutions. Such substitution can significantly reduce the binding ability of Fc fragment to Fc? receptors (Fc?R), and reduce the non-specific activation of T cells by antibodies (such as anti-CD3 antibodies).

Abstract: The present invention provides a selective CXCR4 binding peptide conjugate (“PC”), and a method for using and producing the same. In particular, the selective CXCR4 binding peptide conjugate of the invention comprises a peptide portion that selectively binds to CXCR4 and a medically useful compound, such as an imaging agent, a diagnostic agent, or a therapeutically or pharmaceutically active compound. In one particular embodiment, the selective CXCR4 binding peptide conjugate (“PC”) is of the formula: or a pharmaceutically acceptable salt thereof, wherein a, b, AA1, AA2, Ar1, X1, and AA3 are those defined herein. The peptide conjugate of the invention can be used in a variety of medical applications including, but not limited to, a targeted drug delivery or imaging a patient or diagnosing a patient for a disease or a clinical condition associated with overexpression and/or upregulation of CXCR4, such as cancers, HIV infection, and immune disorders.

Abstract: Provided in the present application is a humanized and multifunctional CD3 antibody; a heavy chain variable region of the CD3 antibody comprised herein contains the amino acid sequence of any one of SEQ ID NOs: 1-3 or a variant sequence thereof; and a light chain variable region thereof contains the amino acid sequence of any one of SEQ ID NOs: 26-28 or a variant sequence thereof. Further provided in the present application is a multifunctional antibody comprising (a) a light chain-heavy chain pair that has specificity for tumor cells or microorganisms; and (b) a fusion peptide that comprises a single-chain variable fragment and an Fc fragment having a CH2 domain and/or a CH3 domain, the fusion peptide having specificity for immune cells. The antibodies provided in the present application have improved biological activity, thermal stability and/or acid resistance.

Abstract: A radiator and a plant illumination lamp containing the radiator. The radiator includes a heat-radiating baseplate configured for fixing a heat source, and heat-radiating side plates connected to the heat-radiating baseplate. The heat-radiating side plates each are provided with a plurality of heat-exchanging through grooves running through the heat-radiating side plates. The heat-exchanging through groove forms a heat potential difference, so that under the influence of the heat potential difference, the cold air outside the radiator passes through the heat-exchanging through groove on the heat-radiating side plates, and then flows out through a hot air chamber and an air outlet at an upper end of the hot air chamber after exchanging heat with the heat-exchanging through groove on the heat-radiating side plates, so as to form a strong natural air convection.

Abstract: Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.

Abstract: The present application discloses a supported PtZn intermetallic alloy catalyst, a method for preparing the same and application thereof. The catalyst uses SiO2 as a support and Zn as a promoter, and a small amount of active component Pt is supported; the weight percentage of Pt is 0.025%-1%, and the weight percentage of Zn is 0.025%-1.7%, a co-impregnation method is adopted in preparation, the SiO2 support is impregnated in aqueous solution of chloroplatinic acid and zinc nitrate, and then drying and high-temperature reduction are performed to obtain a PtZn/SiO2 catalyst. The catalyst has the advantages of high activity, high stability, low price and low toxicity. The catalyst provided by the present application is applicable to preparation of alkene through short-chain alkane dehydrogenation, in particular to preparation of propylene through propane dehydrogenation in a hydrogen atmosphere.

Abstract: A device and method controlling working state change of a small cell and a base station including the device. The device includes: an information acquiring unit that acquires interference between a small cell to be controlled and an adjacent small cell and/or load of the small cell to be controlled; and a state change determination unit that determines working state change to be performed by the small cell to be controlled according to the acquired interference and/or load. The working state includes multiple sleep levels from low to high. A sleep degree of the small cell to be controlled in a low sleep level is less than a sleep degree of the small cell to be controlled in a high sleep level, the working state change being performed among multiple sleep levels.

Abstract: The present invention provides a selective CXCR4 binding peptide conjugate (“PC”), and a method for using and producing the same. In particular, the selective CXCR4 binding peptide conjugate of the invention comprises a peptide portion that selectively binds to CXCR4 and a medically useful compound, such as an imaging agent, a diagnostic agent, or a therapeutically or pharmaceutically active compound. In one particular embodiment, the selective CXCR4 binding peptide conjugate (“PC”) is of the formula: or a pharmaceutically acceptable salt thereof, wherein a, b, AA1, AA2, Ar1, X1, and AA3 are those defined herein. The peptide conjugate of the invention can be used in a variety of medical applications including, but not limited to, a targeted drug delivery or imaging a patient or diagnosing a patient for a disease or a clinical condition associated with overexpression and/or upregulation of CXCR4, such as cancers, HIV infection, and immune disorders.

Abstract: Provided herein are peptides and peptide analogs and methods of treating a metabolic disease, e.g., obesity, diabetes, methods of treating cancer, methods of treating a liver disease, and methods of modulating fatty acid metabolism.