Abstract: A technique of renal denervation comprising methods and devices for generating one or more bubbles to at least partially fragment a calcification of a calcified region of a renal artery and for ablating one or more nerves about, within, or surrounding the calcified region of the renal artery after the calcification has been at least partially fragmented. Other embodiments are described and claimed.

Abstract: An apparatus comprising an ultrasound transducer configured for emitting ultrasound is provided. The ultrasound transducer comprises a hollow piezoelectric transducer body having a longitudinal axis and a radially inner surface, a tubular backing support member extending longitudinally through the piezoelectric transducer body and having a radially outer surface, a chamber defined between the radially inner surface of the piezoelectric transducer body and the radially outer surface of the tubular backing support member and between a first end and an opposite second end in an axial direction, wherein said ends are each formed by a conductive part and a gas-tight sealing layer of metal solder material in contact with the surface of the conductive part, which is opposite to the chamber.

Abstract: Techniques for evaluating neural electrical activity of renal nerves of a patient for which a renal denervation procedure has been or is going to be performed are described. A distal portion of a guide catheter is inserted through an abdominal aorta so the distal portion is positioned adjacent to a renal artery ostium, or in a proximal portion of the renal artery. The guide catheter is used to insert a distal portion of a mapping catheter within the renal artery, and a stimulation electrode positioned in the abdominal aorta (within a specified distance of the renal artery ostium) is used to deliver electrical stimulation pulse(s) to evoke a neural electrical response from renal nerves in tissue surrounding the renal artery. A sense electrode positioned in the renal artery, downstream from the stimulation electrode, is used to sense the neural electrical activity evoked in response to the stimulation pulse(s).

Abstract: Certain methods and systems described herein use a transducer used to produce ablation energy (aka denervation energy) to also evoke a neural response before and/or after denervation energy is delivered. Rather than the neural response being invoked in response to electrical stimulus, it is invoked in response to the transducer (e.g., RF, microwave, or ultrasound transducer) being used to sufficiently heat the nerves in tissue surrounding a biological lumen to an extent that a neural response is evoked without denervating the nerves. That is, the transducer used for performing ablation (aka denervation) is also used to evoke a neural response prior to (and/or after) ablation is performed, by using the transducer to sufficiently heat the nerves in the tissue surrounding the biological lumen to an extent that a neural response is evoked without denervating the nerves. This can reduce the catheter production complexity and costs. Other embodiments are also disclosed.

Abstract: Tissue treatment systems and methods are disclosed. A tissue treatment system comprises a signal generator, a sensing circuit coupleable to electrode(s) of a catheter, and a controller. The sensing circuit senses neural activity of nerves within tissue surrounding a biological lumen using electrode(s) of the catheter inserted into the biological lumen. The controller determines one or more characteristics of the sensed neural activity of the nerves within the tissue surrounding the biological lumen. The controller also selects one or more denervation parameters based on the one or more characteristics of the sensed neural activity, and controls the signal generator to generate, using the selected one or more denervation parameters, signals for performing a denervation procedure intended to denervate at least some of the nerves for which the neural activity was sensed.

Abstract: Color Doppler imaging with line artifact reduction is provided in multi-beam scanning. Doppler estimates representing the same spatial location but calculated from spatially distinctive transmit beam groups are combined through weighted linear interpolation. Methods of calculating the linear interpolation weights are provided based on geometric relationships and optimization functions. Complete overlapping and superposition among receive beams in the interpolation region are not required. Partial interpolation among the receive beams, where only the estimates of the outer receive scan lines may overlap and be interpolated while estimates for scan lines closer to the transmit scan line are not interpolated, allowing for more rapid frame rate.

Abstract: A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

Abstract: A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The system compares the parameter curve of the fluid parameter to a reference curve and, based on the comparison, determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.

Abstract: A catheter has at least a first transducer located in an interior of at least a first balloon, the first transducer configured to be operated at an operational frequency.

Abstract: Color Doppler imaging with line artifact reduction is provided in multi-beam scanning. Doppler estimates representing the same spatial location but calculated from spatially distinctive transmit beam groups are combined through weighted linear interpolation. Methods of calculating the linear interpolation weights are provided based on geometric relationships and optimization functions. Complete overlapping and superposition among receive beams in the interpolation region are not required. Partial interpolation among the receive beams, where only the estimates of the outer receive scan lines may overlap and be interpolated while estimates for scan lines closer to the transmit scan line are not interpolated, allowing for more rapid frame rate.

Abstract: A tissue treatment catheter and system include a catheter shaft sized and shaped for delivery through a radial artery to a blood vessel of a patient. The catheter shaft has several lumens, including a guidewire lumen, a cable lumen, and one or more fluid lumens. A stiffening web extends from the guidewire lumen and is thicker than an outer wall of the catheter shaft. The tissue treatment catheter and system include an ultrasound transducer, a balloon surrounding the ultrasound transducer, and a single electrical cable electrically connected to the ultrasound transducer to deliver sufficient electrical energy during sonication to the transducer such that the transducer thermally induces modulation of neural fibers surrounding the blood vessel sufficient to improve a measurable physiological parameter corresponding to a diagnosed condition of the patient. Other embodiments are described and claimed.

Abstract: Color Doppler imaging with line artifact reduction is provided in multi-beam scanning. Doppler estimates representing the same spatial location but calculated from spatially distinctive transmit beam groups are combined through weighted linear interpolation. Methods of calculating the linear interpolation weights are provided based on geometric relationships and optimization functions. Complete overlapping and superposition among receive beams in the interpolation region are not required. Partial interpolation among the receive beams, where only the estimates of the outer receive scan lines may overlap and be interpolated while estimates for scan lines closer to the transmit scan line are not interpolated, allowing for more rapid frame rate.

Abstract: Described herein are acoustic-based tissue treatment systems, apparatuses, and methods for use therewith. Certain such apparatuses comprise a catheter sized and shaped for delivery through a radial artery including a catheter shaft having distal and proximal ends, a plurality of lumens extending longitudinally through the catheter shaft between the distal and proximal ends thereof, and an ultrasound transducer distally positioned relative to the distal end of the catheter shaft. A balloon may surround the ultrasound transducer and at least one of the plurality of lumens may be configured to provide a cooling fluid to the balloon at a pressure and flow rate sufficient to protect non-target tissue in the blood vessel wall from thermal injury.

Abstract: A heart rate monitor provides a pulse or heartbeat, but without the on-going or continuous phase signal of ECG and/or with a delay relative to the actual heartbeat. For phase determination in echocardiography, the heartbeat from the heart rate monitor is used to assist in identification of phase from acquired ultrasound data. Rather than relying on just ECG or just image processing, the worn or handheld heart rate monitor is used to simplify the image process-based identification of phase.

Abstract: Coherent combination of ultrasound data for collinear receive beams adapts to the ultrasound data. Beam-to-beam coherence metrics, such as correlation coefficient and/or phase change or functions of these parameters, are used to adapt weighting of the ultrasound data for the receive beams prior to combination or to adapt the results of the combination.

Abstract: Line artifact reduction is provided in multi-beam scanning for Doppler imaging. An analytic solution uses estimated velocities for collocated receive scan lines from different transmit beams to reduce or remove the biases caused by multi-beam receive. For each location, a line or curve is fit to the estimated velocities as a function of distance of the transmit scan lines to the location. The velocity at an intercept of this line with the distance of zero (intercept with the origin) indicates the unbiased velocity. This approach allows a solution even where all of the velocity estimates have a bias with the same sign, such as due to the location being on a same side of the different transmit scan lines.

Abstract: Guidance is provided in stress echocardiography. The recovery time after cessation of the stress is predicted using patient-specific information. The prediction may assist the user in acquiring images of the heart for stress echocardiography during the patient-relevant period, avoid unnecessary rush, and/or avoid acquisition of less useful images.

Abstract: Color Doppler imaging with line artifact reduction is provided in multi-beam scanning. Doppler estimates representing the same spatial location but calculated from spatially distinctive transmit beam groups are combined through weighted linear interpolation. Methods of calculating the linear interpolation weights are provided based on geometric relationships and optimization functions. Complete overlapping and superposition among receive beams in the interpolation region are not required. Partial interpolation among the receive beams, where only the estimates of the outer receive scan lines may overlap and be interpolated while estimates for scan lines closer to the transmit scan line are not interpolated, allowing for more rapid frame rate.

Abstract: Color Doppler imaging with line artifact reduction is provided in multi-beam scanning. Doppler estimates representing the same spatial location but calculated from spatially distinctive transmit beam groups are combined through weighted linear interpolation. Methods of calculating the linear interpolation weights are provided based on geometric relationships and optimization functions. Complete overlapping and superposition among receive beams in the interpolation region are not required. Partial interpolation among the receive beams, where only the estimates of the outer receive scan lines may overlap and be interpolated while estimates for scan lines closer to the transmit scan line are not interpolated, allowing for more rapid frame rate.

Abstract: A heart rate monitor provides a pulse or heartbeat, but without the on-going or continuous phase signal of ECG and/or with a delay relative to the actual heartbeat. For phase determination in echocardiography, the heartbeat from the heart rate monitor is used to assist in identification of phase from acquired ultrasound data. Rather than relying on just ECG or just image processing, the worn or handheld heart rate monitor is used to simplify the image process-based identification of phase.