Abstract: The present invention relates to a novel multilayered assembly for the prolonged delayed and controlled diffusion of an active agent or a drug, in particular into an aqueous medium. In particular, the present invention relates to a nano-sized drug delivery structure comprising at least one support material; one multilayered structure overlaying and/or surrounding at least partially said support material and comprising at least two layers of oppositely charged materials; and one drug active agent conjugated by means of a disulphide bond on one or more negatively charged material(s) of one or more inner layer(s) of the said multilayered structure. Such a nano-sized drug delivery structure is more particularly useful for the manufacture of pharmaceutical compositions, for example intended to be used in cancer therapy. Internalization of the drug nanostructures into cancer cells, retardation of diffusion of the active drug, activity and specific targeting of the drug nanostructures were tested.

Abstract: A fabrication process to connect branch ventilating ducts to main ventilating ducts comprising: a, use non-combustible sandwich panels which are consisted by substrates on both sides and non-combustible material in middle to form a main air duct and a branch duct, both have rectangular cross-section; b, open on side panels of the main air duct birdsmouths (10) corresponding to a diameter of the branch air duct; c, attach a connector (21) on the branch duct to the birdsmouth (10). Therefore the manufactured air duct includes a connecting structure of a branch ventilating ducts with a main ventilating ducts, wherein in the main air duct (11) is located the birdsmouth (10) whose dimension is matching to the diameter of the branch air duct, and at the end of the branch air duct (22) is formed the connector (21).

Abstract: Disclosed herein is a method of making a film, the method comprising depositing a first layer polyelectrolyte on a surface of a substrate to form a first layer; and depositing a second layer polyelectrolyte on the first layer polyelectrolyte to form a second layer. The first layer polyelectrolyte, the second layer polyelectrolyte, or both, is deposited on the substrate in the presence of a polymeric precipitant; and the first layer polyelectrolyte and the second layer polyelectrolyte have net charges of opposite polarity. Also disclosed are methods of improving bioactive molecule retention during fabrication of a polyelectrolyte multilayer film.