Patents by Inventor Liangliang Sun
Liangliang Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115844Abstract: A particle storage tube (100) used for implanting microparticles into a body in cooperation with a puncture needle (500), and comprising an accommodation portion (1) and a drug delivery portion (2). The accommodation portion (1) is an elongated hollow tube having a channel (10) used to accommodate microparticles (4). One end of the accommodation portion (1) is connected to the drug delivery portion (2), and the other end of the accommodation portion (1) is an open part (11) used to discharge the microparticles out of the particle storage tube (100). The inner diameter of the channel (10) is 1.0-1.8 times the inner diameter of a lumen (502) of the puncture needle (500). An inner chamber (20) of the drug delivery portion (2) is in communication with the channel (10), and is used for delivering liquid medicine (200) to the channel (10).Type: ApplicationFiled: December 17, 2023Publication date: April 11, 2024Applicant: SUZHOU YIBEN LIFE TECHNOLOGY CO., LTDInventors: Shaoge GU, Yonghua DONG, Lei JIN, Liangliang ZHAO, Guoxiang SUN
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Patent number: 11950199Abstract: A method performed by a network node for handling a communication session in a wireless communication network. The network node receives from a user equipment (UE) a registration message for re-registering the UE to a session. The network node further verifies the registration message based on registration information previously stored for the UE When verified in response to the reception, transmits back to the UE, a registration response along with a terminating request for a call establishment.Type: GrantFiled: April 24, 2019Date of Patent: April 2, 2024Assignee: Telefonaktiebolaget LM Ericsson (publ)Inventors: Debashish Pattnaik, Liangliang Guo, Songmao Li, Erqun Sun
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Publication number: 20240092899Abstract: Provided is a bispecific antibody, comprising a first antigen-binding moiety and a second antigen-binding moiety, wherein a paired domain of the first antigen-binding moiety comprises an amino acid sequence of engineered HLA-I ?3 and an amino acid sequence of engineered ?2M. Also provided are an expression method for the bispecific antibody, a polynucleotide encoding the bispecific antibody, a vector and host cell containing the polynucleotide, a pharmaceutical composition containing the bispecific antibody, a fusion protein, and a conjugate.Type: ApplicationFiled: January 27, 2022Publication date: March 21, 2024Inventors: Liangliang WANG, Zhengping ZHANG, Congcong SUN, Rongjuan ZHAO, Yimeng LI
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Publication number: 20240090299Abstract: A display panel includes: multiple light-emitting devices arranged on a substrate, each light-emitting device includes a first electrode, multiple light-emitting units and a second electrode sequentially arranged in a direction away from the substrate, a microcavity structure is formed between the first electrode and the second electrode, the light-emitting unit includes a light-emitting layer, light-emission colors of at least two light-emitting layers in the same light-emitting device are different, and at least one light-emitting device includes a cavity length adjusting layer; and a color conversion layer including multiple wavelength conversion units, each wavelength conversion unit corresponds to a light-emitting device having the cavity length adjusting layer, the wavelength conversion unit is arranged on a light outlet side of the light-emitting device, at least one light-emission peak in a light-emission band of the light-emitting device is less than or equal to an intrinsic light-emission peak of aType: ApplicationFiled: July 1, 2022Publication date: March 14, 2024Inventors: Qian JIN, Wei HUANG, Qian SUN, Tianhao LU, Yang LI, Liangliang KANG
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Publication number: 20240076277Abstract: A system and method for preparing epoxy chloropropane is provided in that by coupling three stages of high gravity reactors, the product epoxy chloropropane and water vapor are distilled from a reaction system in form of an azeotrope by adopting a water vapor steam stripping method. Further, by combining the azeotrope with the multiples stages of high gravity reactors, the gas phase mass transfer and the liquid phase mass transfer of the azeotrope are improved aiming at the features of the azeotrope in the reaction system, thus making the overall conversion rate higher. In addition, by combining steam stripping and high gravity, dichloropropanol and alkali solution are rapidly mixed for mass transfer, and the product epoxy chloropropane is rapidly distilled from the reaction system in the form of the azeotrope, such that the reaction proceeds continuously towards the direction of producing epoxy chloropropane, thus significantly improving the conversion rate.Type: ApplicationFiled: December 24, 2021Publication date: March 7, 2024Inventors: Liangliang ZHANG, Liyang ZHOU, Guangwen CHU, Bibo XIA, Jianfeng CHEN, Yutu JIANG, Jihong TONG, Baochang SUN, Wei MAO, Yanchun ZHENG
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Publication number: 20230051334Abstract: The present invention discloses a method comprising: A. acquiring the current I0 and I, and setting It1, It2, IR, Vmin, and Vmax. B. acquiring the speed V, and setting the speed VL and VH; C. a mowing motor runs in a low-speed mode, and a self-propelled motor runs at the speed VH; D. when encountering grassy areas, if I0<I<It1, keeping unchanged; if I?It1 and lasting for T1, skipping to E; if I=IR, skipping to G; E. the mowing motor switches to the high-speed mode; F. the mowing motor switches to the low-speed mode, V is switched to VH; G the mowing motor switches to the high-speed mode, V is adjusted to VL; H. the mowing motor stops, the self-propelled motors stop, then retreat and work along the original path, after attempting for M times, if the self-propelled motors stop again, bypassing and skipping to C to continue working.Type: ApplicationFiled: October 25, 2021Publication date: February 16, 2023Applicant: ZHEJIANG SAFUN INDUSTRIAL CO., LTD.Inventors: Jianbing GUO, Jie LI, Linqiang ZHUANG, Feixiang ZHOU, Changda WU, Li HUANG, Liangliang SUN, Yingying SUN, Xinsen YING
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Patent number: 11056329Abstract: An electrokinetically pumped sheath flow nanospray interface for capillary electrophoresis coupled to negative mode electrospray mass spectrometer is described. At this interface, application of an electric field generates electro-osmotic flow at the interior of a glass emitter having an orifice. Electroosmotic flow pumps liquid around the distal tip of the separation capillary, ensheathing analyte into the electrospray electrolyte. In negative ion mode, negative potential applied to an untreated emitter drives sheath flow away from the emitter orifice, decreasing the stability and efficiency of the spray. In contrast, when the interior of the electrospray emitter is grafted with aminoalkylsilanes, the amines have a positive charge, which reverses electroosmosis and generates stable sheath flow to the emitter orifice under negative potential. Limits of detection were about 150 to 900 attomoles injected.Type: GrantFiled: December 30, 2016Date of Patent: July 6, 2021Assignee: University of Notre Dame du LacInventors: Norman Dovichi, Scott Sarver, Nicole Schiavone, Zhenbin Zhang, Liangliang Sun
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Publication number: 20200273693Abstract: An electrokinetically pumped sheath flow nanospray interface for capillary electrophoresis coupled to negative mode electrospray mass spectrometer is described. At this interface, application of an electric field generates electro-osmotic flow at the interior of a glass emitter having an orifice. Electroosmotic flow pumps liquid around the distal tip of the separation capillary, ensheathing analyte into the electrospray electrolyte. In negative ion mode, negative potential applied to an untreated emitter drives sheath flow away from the emitter orifice, decreasing the stability and efficiency of the spray. In contrast, when the interior of the electrospray emitter is grafted with aminoalkylsilanes, the amines have a positive charge, which reverses electroosmosis and generates stable sheath flow to the emitter orifice under negative potential. Limits of detection were about 150 to 900 attomoles injected.Type: ApplicationFiled: December 30, 2016Publication date: August 27, 2020Applicant: University of Notre Dame du LacInventors: Norman DOVICHI, Scott SARVER, Nicole SCHIAVONE, Zhenbin ZHANG, Liangliang SUN
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Patent number: 10578580Abstract: The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically pumped nanoelectrospray interface to a mass spectrometer. The nanoelectrospray emitter employed an acidic sheath electrolyte. To realize automated focusing and mobilization, a plug of ammonium hydroxide was first injected into the capillary, followed by a section of mixed sample and ampholyte. As focusing progressed, the NH3H2O section was titrated to lower pH buffer by the acidic sheath buffer. Chemical mobilization started automatically once the ammonium hydroxide was consumed by the acidic sheath flow electrolyte.Type: GrantFiled: September 22, 2017Date of Patent: March 3, 2020Assignee: University of Notre Dame du LacInventors: Norman Dovichi, Guijie Zhu, Liangliang Sun
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Patent number: 10416115Abstract: A method of coating the inside wall of a capillary with a polymeric material for capillary electrophoresis is disclosed. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.Type: GrantFiled: June 20, 2016Date of Patent: September 17, 2019Assignee: University of Nortre Dame du LacInventors: Norman Dovichi, Guijie Zhu, Liangliang Sun
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Publication number: 20190004010Abstract: The invention provides a capillary isoelectric focusing (cIEF) system based on a sandwich injection method for automated chemical mobilization. This system was coupled with an electrokinetically pumped nanoelectrospray interface to a mass spectrometer. The nanoelectrospray emitter employed an acidic sheath electrolyte. To realize automated focusing and mobilization, a plug of ammonium hydroxide was first injected into the capillary, followed by a section of mixed sample and ampholyte. As focusing progressed, the NH3H2O section was titrated to lower pH buffer by the acidic sheath buffer. Chemical mobilization started automatically once the ammonium hydroxide was consumed by the acidic sheath flow electrolyte.Type: ApplicationFiled: September 22, 2017Publication date: January 3, 2019Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Norman DOVICHI, Guijie ZHU, Liangliang SUN
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Publication number: 20170363576Abstract: The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.Type: ApplicationFiled: June 20, 2016Publication date: December 21, 2017Applicant: University of Notre Dame du LacInventors: Norman DOVICHI, Guijie ZHU, Liangliang SUN
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Patent number: 9465014Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.Type: GrantFiled: April 5, 2015Date of Patent: October 11, 2016Assignee: University of Notre Dame du LacInventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
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Patent number: 9362102Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.Type: GrantFiled: July 7, 2015Date of Patent: June 7, 2016Assignee: University of Notre Dame du LacInventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
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Publication number: 20150311056Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.Type: ApplicationFiled: July 7, 2015Publication date: October 29, 2015Applicant: University of Notre Dame de LacInventors: Norman Dovichi, Liangliang Sun, Guijie Zhu
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Publication number: 20150233877Abstract: The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.Type: ApplicationFiled: April 5, 2015Publication date: August 20, 2015Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Norman Dovichi, Liangliang Sun, Guijie Zhu