Abstract: Provided are a quinazoline derivative of formula (II) and a preparation method therefor, the quinazoline derivative being used as a KRAS G12C mutation inhibitor. The KRAS G12C mutation inhibitor can more efficiently inhibit KRAS G12C mutation, prevents drug-resistant mutation, and has good metabolic stability.

Abstract: An underwater debris suction apparatus includes a power device and a filter device. The power device includes a suction component and a power drive device configured to provide power for the suction component. The underwater debris suction apparatus further includes a collection device, and the upper end of the collection device is provided with an opening. The suction component is at least partially located above the filter device or is entirely located in the space of the filter device. During operation of the suction component, unfiltered pool water enters the filter device through a water inlet channel and flows to the side wall of the filter device, so that the filtered water is discharged from the side wall of the filter device, and the debris that cannot be discharged from the side wall of the filter device falls into the collection device.

Abstract: The present application relates to azaaromatic amide derivatives for the treatment of cancer. Specifically, the present application relates to a preparation method and use of azaaromatic amide derivatives. The present application relates to azaaromatic amide derivatives and anilino-pyrimidine compounds represented by formula (I), formula (II), formula (III), formula (IV), and formula (V), and pharmaceutically acceptable salts thereof; the compounds or salts thereof can be used to treat or prevent a disease or disorder by regulating certain mutant forms of epidermal growth factor receptors. The present application also relates to a pharmaceutical composition comprising the compounds or salts thereof, and a method for treating various diseases mediated by EGFR, or HER2, or HER4 by using the compounds and salts thereof.

Abstract: The present application relates to the crystalline form of the mesylate salt, the crystalline form of the hydrochloride salt and the crystalline form of the maleate salt of a compound of formula (I): The present application also relates to a method for treating non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutation using the crystalline forms. The present application also relates to synthetic routes for the compound of formula (I).

Abstract: A battery module includes: a battery cell component, including at least two battery cells arranged in a preset direction; a conductive element, wherein adjacent battery cells are electrically connected through the conductive element; and a protection circuit board, wherein the battery cells located at two ends of the battery cell component are electrically connected to the protection circuit board through corresponding tabs, respectively.

Abstract: The invention provides, in one aspect, a compound represented by formula (I) or a stereoisomer, tautomer or pharmaceutical salt thereof, and use thereof in preparation of a medicament for preventing and/or treating estrogen receptor (ER)-related diseases or disorders.

Abstract: An anti-FGFR2 antibody, an encoding nucleic acid of the antibody, a vector and host cell for the expression and production thereof, an antibody-drug conjugate, and a pharmaceutical composition comprising the antibody. The present invention further relates to the use of the antibody molecule in a drug for diagnosing a cancer caused by FGFR2-pathway-related dysregulation, and the use of the antibody or antibody-drug conjugate in the preparation of a medicament for treating a cancer caused by FGFR2-pathway-related dysregulation, in particular gastric cancer.

Abstract: A mechanism for detecting obstacles and mechanically reversing (a direction of) a pool cleaner includes a drive part in non-rotatable connection with a cleaner housing, an arresting assembly connected to the cleaner housing, and a rotary direction-changing assembly rotatably connected to the cleaner housing or the drive part. The arresting assembly cooperates with the rotary direction-changing assembly. The mechanism for detecting obstacles and mechanically reversing (a direction of) a pool cleaner is compact in structure, low in manufacturing cost, and can perform obstacle detection and change a direction of the pool cleaner. With the structure of the rotary direction-changing assembly capable of rotating relative to the cleaner housing, the cleaner, when meeting an obstacle, is allowed to change the traveling direction, thereby resulting in a high working efficiency.

Abstract: The present application relates to a salt formed from a compound of formula (I) with an acid: wherein the acid is selected from hydrochloric acid, methanesulfonic acid, benzenesulfonic acid, ethanesulfonic acid, maleic acid, hydrobromic acid, citric acid, L-tartaric acid, and p-toluenesulfonic acid. The present application also relates to a method for treating non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutation using the salt.

Abstract: A radiation effect shielding calculation method based on a three-dimensional spacecraft model is provided.

Abstract: A radiation effect shielding calculation method based on a three-dimensional spacecraft model is provided.

Abstract: A battery module includes: a battery cell component, including at least two battery cells arranged in a preset direction; a conductive element, wherein adjacent battery cells are electrically connected through the conductive element; and a protection circuit board, wherein the battery cells located at two ends of the battery cell component are electrically connected to the protection circuit board through corresponding tabs, respectively.

Abstract: An underwater debris suction apparatus includes a power device and a filter device. The power device includes a suction component and a power drive device configured to provide power for the suction component. The underwater debris suction apparatus further includes a collection device, and the upper end of the collection device is provided with an opening. The suction component is at least partially located above the filter device or is entirely located in the space of the filter device. During operation of the suction component, unfiltered pool water enters the filter device through a water inlet channel and flows to the side wall of the filter device, so that the filtered water is discharged from the side wall of the filter device, and the debris that cannot be discharged from the side wall of the filter device falls into the collection device.

Abstract: The present application relates to azaaromatic amide derivatives for the treatment of cancer. Specifically, the present application relates to a preparation method and use of azaaromatic amide derivatives. The present application relates to azaaromatic amide derivatives and anilino-pyrimidine compounds represented by formula (I), formula (II), formula (III), formula (IV), and formula (V), and pharmaceutically acceptable salts thereof; the compounds or salts thereof can be used to treat or prevent a disease or disorder by regulating certain mutant forms of epidermal growth factor receptors. The present application also relates to a pharmaceutical composition comprising the compounds or salts thereof, and a method for treating various diseases mediated by EGFR, or HER2, or HER4 by using the compounds and salts thereof.

Abstract: A mechanism for detecting obstacles and mechanically reversing (a direction of) a pool cleaner includes a drive part in non-rotatable connection with a cleaner housing, an arresting assembly connected to the cleaner housing, and a rotary direction-changing assembly rotatably connected to the cleaner housing or the drive part. The arresting assembly cooperates with the rotary direction-changing assembly. The mechanism for detecting obstacles and mechanically reversing (a direction of) a pool cleaner is compact in structure, low in manufacturing cost, and can perform obstacle detection and change a direction of the pool cleaner. With the structure of the rotary direction-changing assembly capable of rotating relative to the cleaner housing, the cleaner, when meeting an obstacle, is allowed to change the traveling direction, thereby resulting in a high working efficiency.

Abstract: An installation tool for forcibly inserting a first work piece into a fitting hole of a second work piece comprises a body, a holding head, a power lever, and a hammering tool. The body has a front end and a rear end opposite the front end in a longitudinal direction. The holding head is connected to the front end of the body and configured to hold the second work piece. The power lever is movably mounted on the body and extends in the longitudinal direction. The hammering tool is configured to hammer the power lever to exert an impact force on the power lever, the power lever pushing the first work piece in the longitudinal direction under the impact force to forcibly insert the first work piece into the fitting hole of the second work piece.

Abstract: A method of laying an optical fiber comprises providing a continuous optical fiber, a first segment of optical-electrical hybrid cable having a first fiber receiving tube, and a second segment of optical-electrical hybrid cable having a second fiber receiving tube. The optical fiber is laid into the first fiber receiving tube using an air-blowing device. A leading end of the optical fiber is fixed in a transfer apparatus after the leading end passes through an outlet of the first fiber receiving tube. A portion of the optical fiber which has passed through the first segment is wound in the transfer apparatus until the optical fiber is completely laid in the first segment. The leading end of the optical fiber is detached from the transfer apparatus. The portion of the optical fiber which has passed through the first segment is laid into the second fiber receiving tube using the air-blowing device.

Abstract: The application discloses a power source adaptor for charging directly, where the power source adaptor for charging directly is timed to communicate wirelessly with a mobile terminal which is a charging object, to obtain a change in voltage of a battery in the mobile terminal, adjusts dynamically a volt value of charging voltage output by the power source adaptor for charging directly according to the varying voltage of the battery, and charges directly the battery in the mobile terminal using the charging voltage.

Abstract: An installation tool for forcibly inserting a first work piece into a fitting hole of a second work piece comprises a body, a holding head, a power lever, and a hammering tool. The body has a front end and a rear end opposite the front end in a longitudinal direction. The holding head is connected to the front end of the body and configured to hold the second work piece. The power lever is movably mounted on the body and extends in the longitudinal direction. The hammering tool is configured to hammer the power lever to exert an impact force on the power lever, the power lever pushing the first work piece in the longitudinal direction under the impact force to forcibly insert the first work piece into the fitting hole of the second work piece.

Abstract: A method of laying an optical fiber comprises providing a continuous optical fiber, a first segment of optical-electrical hybrid cable having a first fiber receiving tube, and a second segment of optical-electrical hybrid cable having a second fiber receiving tube. The optical fiber is laid into the first fiber receiving tube using an air-blowing device. A leading end of the optical fiber is fixed in a transfer apparatus after the leading end passes through an outlet of the first fiber receiving tube. A portion of the optical fiber which has passed through the first segment is wound in the transfer apparatus until the optical fiber is completely laid in the first segment. The leading end of the optical fiber is detached from the transfer apparatus. The portion of the optical fiber which has passed through the first segment is laid into the second fiber receiving tube using the air-blowing device.