Abstract: This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. The compounds provide an improved therapeutic index in the treatment of diabetes, cancer, acromegaly and retenosis. Many of the compounds are also orally active. Thus, it is an object of this invention to describe such compounds. It is a further object to describe the specific preferred stereoisomers of the somatostastin agonists. A still further object is to describe processes for the preparation of such compounds. Another object is to describe methods and compositions which use the compounds as the active ingredient thereof. Further objects will become apparent from reading the following description.

Abstract: Di and trisubstituted Piperidines, pyrrolidines and hexahydro-1H-azepines which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible mea products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di- and trisubstituted piperidines and pyrrolidines as the active ingredient thereof are also disclosed.