Patents by Inventor Lianhong Sun

Lianhong Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Directed evolution of galactose oxidase enzymes
    Patent number: 7115403
    Abstract: This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantageously produced in conventional or facile expression systems. Various methods for directed evolution of polynucleotide sequences can be used to obtain the improved sequences. The improved characteristics of the polypeptides or proteins generated in this manner include improved expression, enhanced activity toward one or more substrates, and increased thermal stability. In a particular embodiment, the invention relates to improved expression of the galactose oxidase gene and galactose oxidase enzymes. GAO mutants that are highly active and/or thermostable are disclosed.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: October 3, 2006
    Assignee: The California Institute of Technology
    Inventors: Frances H. Arnold, Ioanna P. Petrounia, Lianhong Sun
  • Directed evolution of oxidase enzymes
    Patent number: 7098010
    Abstract: This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantagoeusly produced in conventional or facile expression systems. Various methods for directed evolution of polynucleotide sequences can be used to obtain the improved sequences. The improved characteristics of the polypeptides or proteins generated in this manner include improved expression, enhanced activity toward one or more substrates, and increased thermal stability. In a particular embodiment, the invention relates to improved expression of the galactose oxidase gene and galactose oxidase enzymes. GAO mutants that are highly active and/or thermostable are disclosed.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: August 29, 2006
    Assignee: California Institute of Technology
    Inventors: Frances H. Arnold, Ioanna P. Petrounia, Lianhong Sun