Abstract: A processing cartridge can be detachably installed in an electronic image forming device, where a protrusion capable of extending and retracting along a vertical direction is disposed inside the electronic image forming device. The processing cartridge includes a toner container and a waste toner container; and a movable element disposed at the lower side of the processing cartridge. The processing cartridge further includes a detachment preventing portion; the movable element is disposed with an abutting portion; and the abutting portion is capable of being abutted against the detachment preventing portion to prevent the movable element being disengaged. The processing cartridge further includes an elastic element; and the elastic element is configured to move the movable element toward the lower side of the processing cartridge.

Abstract: The present invention provides a bispecific CS1-BCMA CAR-T cell and an application thereof. Specifically, the present invention provides a bispecific CAR, which comprises CS1 scFv and BCMA scFv, and a 4-1BB co-stimulatory domain and a CD3 activation domain. The bispecific CAR-T cell in the present invention has a significant killing effect on CS1 positive target cells and BCMA positive target cells, and can secrete IFN-? against target cells and significantly inhibit the growth of RPMI8226 xenograft tumor in an in vivo experiment. The present invention further provides a preparation method and an application of the bispecific CAR-T cell.

Abstract: Disclosed are a calibration system (600a) and a calibration support (100a) therefor. The calibration support (100a) comprises: a base (10); a vertical frame assembly (20a), comprising a fixed vertical rod (22) and a movable vertical rod (24), wherein the fixed vertical rod (22) is mounted on the base (10), and the movable vertical rod (24) is capable of moving, within a preset range relative to the base (10), in the length direction of the fixed vertical rod (22); and a cross beam (30a), which is detachably mounted to one of a first mounting seat (35a) and a second mounting seat (36a) which are connected to the movable vertical rod (24), the cross beam (30a) being used for mounting a calibration element, and the calibration element being used for calibrating an advanced driver assistant system of a vehicle.

Abstract: The present invention relates in general to compositions and methods for treating an animal or human patient in need of treatment for ophthalmic diseases or conditions involving oxidative stress and treatment with an ophthalmic implant containing (2R,2R?)-3,3?-disulfanediyl bis(2-cetamidopropanamide) (diNACA), wherein such ophthalmic diseases or conditions include but not limited to cataracts, cataracts in a subject that does not have diabetes, corneal endothelial cell loss, age-related macular degeneration, presbyopia, retinitis pigmentosa (RP), Usher syndrome, Stargardt syndrome, glaucoma, diabetic retinopathy, and/or retinal disease.

Abstract: The present invention relates to a deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide inhibitor, a preparation method therefor, and an application thereof. Specifically, the compound of the present invention has the structure shown in formula (I); also disclosed in the present invention are a preparation method for said compound and the use thereof as an AhR inhibitor; the compound of the present invention has a good selective inhibitory effect on AhR, and has better pharmacodynamics, pharmacokinetic properties, and lower toxic and side effects.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: The disclosure relates to the technical field of automobile maintenance and repair as well as device calibration, and in particular, to a bracket apparatus. The bracket apparatus includes a base, a vertical rod and a clamping assembly. One end of the vertical rod is mounted to the base. The clamping assembly is mounted to the vertical rod. The clamping assembly includes a sliding member, a push rod assembly, a handle and an elastic member. One end of the sliding member is sleeved on the vertical rod. The sliding member is movable along the vertical rod. An other end of the sliding member is configured to carry a calibration element. The push rod assembly can be movably mounted to the sliding member in a preset direction. Two ends of the elastic member respectively abut against an inner wall of the sliding member and the push rod assembly. The elastic member can drive one end of the push rod assembly to be tightly pressed against the vertical rod.

Abstract: Embodiments of the disclosure discloses a calibration bracket. The calibration bracket includes a base, a vertical rod, a transverse force application member and a transverse force application mating member. The vertical rod is detachably mounted to the base. The transverse force application member is disposed on one of the base and the vertical rod. The transverse force application mating member is disposed on the other of the base and the vertical rod and is configured to be connected to the transverse force application member to apply, to the vertical rod, a force parallel to the base. A limiting protrusion is provided on one of the base and the vertical rod. A limiting opening is provided on the other of the base and the vertical rod. The limiting opening can allow the limiting protrusion to pass through the limiting opening and snugly abut against the limiting protrusion when the transverse force application member applies a transverse force to the vertical rod.

Abstract: [Problem] When the number of data radio bearers increases, the number of DL user data messages increases, and as a result, many communication bands in a transmission path are consumed. [Solution] A first message for requesting a report of a data transmission status in a plurality of data radio bearers among first bearers representing data radio bearers established in relation to a second communication device is generated, and the first message is transmitted to the second communication device.

Abstract: The present disclosure provides a process cartridge. The process cartridge includes a cartridge body; a photosensitive drum, rotatably disposed at the cartridge body; a developing roller, rotatably disposed at the cartridge body; a force receiving unit, where the force receiving unit is disposed at an end of the cartridge body and configured to be engaged with a driving unit of an electronic image-forming apparatus to receive a driving force outputted by the driving unit; and a pressing part, where the pressing part is fixedly disposed at the cartridge body and at a same end of the cartridge body as the force receiving unit, and configured to press the driving unit to make the driving unit to be coaxially-aligned; and a distance between the pressing part and an axis of the photosensitive drum is unchanged in displacement during an engagement process of the force receiving unit and the driving unit.

Abstract: The present invention discloses an electrocatalytic Fenton oxidation-electrochemical oxidation coupling process and apparatus for efficient treatment of chemical wastewater, and belongs to the field of sewage treatment. The process includes an electrocatalytic Fenton oxidation step, an electrochemical oxidation step, and a pH adjustment step. A spacing between a cathode and an anode in the electrocatalytic Fenton oxidation step is controlled, so that oxygen produced at the anode reacts at the cathode to produce H2O2. The treatment requirements can be met without external aeration or external addition of H2O2, and meanwhile, the efficiency of COD removal by electro-Fenton oxidation is effectively improved. Further, by connecting a pH adjusting tank with the electrocatalytic Fenton oxidation-electrochemical oxidation coupling apparatus in series, a coupling treatment process with near-zero production of iron sludge is realized.

Abstract: A humanized CD 19 antibody, and a chimeric antigen receptor thereof, an immune cell thereof and the use thereof are provided. The humanized CD19 antibody is based on a FMC63 chimeric antibody, which is subjected to humanization modification. A CAR-T and a dual CAR-T cell constructed based on the humanized antibody and the related use thereof are also provided. Compared with a CAR-T cell constructed by using FMC63, the CAR-T cell constructed based on the humanized antibody has higher killing effect and tumor removal ability.

Abstract: A vehicle-mounted power supply apparatus and a vehicle having same. The vehicle-mounted power supply apparatus (100) includes: a housing (110), a magnetic device (120), and a shielding component (130). A mounting position (111) is arranged in the housing (110). The magnetic device (120) is an integrated part and is arranged at the mounting position (111), The shielding component (130) is arranged in the housing 110), and the shielding component (130) surrounds a periphery of the mounting position (111).

Abstract: A camera assembly for a wheel positioning system includes a base body and a camera main body. The base body is provided with target surfaces which are not in the same plane and are not in the same plane as that of a lens in the camera main body. The target surfaces are respectively provided with target elements, the spatial positional relationship between the target element and the camera main body is known, and the geometric characteristics of the target element are known. Therefore, the position of the camera main body can be determined by acquiring the positions of the target surfaces, and the positions of cameras on two sides of a vehicle can be indirectly determined without using a sensor or a preset camera fixing structure, thereby improving the measurement accuracy of calibration calculation.

Abstract: An isolated CD19-binding chimeric antigen receptor, a CRISPR-Cas9 system-based method for knocking out TRAC, B2M and PD-1 genes in T cells in vitro, crRNA used in the method, gene knockout T cells obtained according to the method, and a use thereof.

Abstract: To enable a communication band between base stations to be efficiently used, a wireless communication system provided with a main base station and a secondary base station. A wireless communication system, wherein when dual connectivity, which is an operation mode that allows connection to both the main base station and the secondary base station by a terminal, is executed, the secondary base station transmits information pertaining to the free buffer space of a wireless data bearer group comprising a plurality of wireless data bearers to the main base station in units of a wireless data bearer group.

Abstract: The present invention relates to an aryl or heteroaryl pyridone or pyrimidine derivative, and a preparation method and use thereof. Specifically, the compounds of the present invention have a structure represented by formula (I). Further disclosed in the present invention are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic, pharmacokinetic performance, and reduced toxic side effects.

Abstract: A vehicle detection system includes a support, machine vision modules, a failure sensor, and a controller. Each machine vision module includes image acquisition devices each including s an image acquisition sensor for obtaining related parameters of hardware to be detected of a vehicle. The failure sensor is used for acquiring position change information of the image acquisition sensor and outputting a motion parameter signal comprising the position change information. The controller is used for determining, according to the motion parameter signal, whether the position of the image acquisition sensor needs to be calibrated. In the using process of the vehicle detection system, the controller can determine in real time whether the position of the image acquisition sensor needs to be calibrated, so as to avoid a miscorrection caused by detecting and correcting the vehicle without precalibration after the measurement and calculation precision of the vehicle detection system is reduced.

Abstract: The present disclosure relates to an engineered immune cell and use thereof. The present disclosure provides an engineered immune cell comprising a CAR or engineered TCR, which CAR or engineered TCR can comprise a first antigen binding domain and a second antigen binding domain. The engineered immune cells of the present disclosure, when administered into a subject, can inhibit the host immune cells such as T cells and/or NK cells and enhance the survival and persistence of the engineered immune cells in vivo, thereby exhibiting more effective tumor killing activity.

Abstract: Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.