Abstract: Disclosed is a method of treating alopecia greata using a compound having the formula: wherein R1 is C10-C24 alkenyl; R2 is H, C1-C6 alkyl, aryl, or aralkyl, where any aryl moiety may be unsubstituted or substituted by nitro, cyano, halo, hydroxyl, NR6R7, or CR8R8NR6R7, where R6, R7, and R8 each independently is H or C1-C6 alkyl; and R3 and R4 each independently is H or C1-C6 alkyl, or R3 and R4 together with the nitrogen atom to which they are attached form a 5-7 membered heterocyclic saturated ring optionally containing an additional N or O, which is unsubstituted or substituted by C1-C6 alkyl, or an enantiomer or a pharmaceutically acceptable salt of the compound.

Abstract: The subject invention provides a compound having the structure: wherein Y is O, NR3R4 or NOR6; R3 is H, alkyl, aralkyl, alkynyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group; R4 is H, alkyl, aralkyl, or alkynyl; R6 is H or C1-C4 alkyl; R1 and R2 are each independently H, alkyl, aralkyl, or alkynyl; the curved line drawn from S to the center of the phenyl ring and the straight line drawn from N to the center of the ring indicate that S and N are part of a 5 membered ring which shares two carbons with the phenyl ring; and the dashed line drawn from the carbon atom on the cyclopentyl ring to Y represents a bond when Y is O or NOR6 and is absent when Y is NR3R4, and wherein wherein X is H or O; and R5 is H, alkyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group, or an enantiomer, or a tautomer, or a pharmaceutically acceptable salt thereof, a process for preparing the compounds and a method of treating Parknison's disease, multiple sclerosis or depression with the compounds of the invention.