Abstract: A method of preparing antimicrobial surface on medical devices: first, producing multi-functional surface with bacterial anti-adhesion and self-cleaning functions through single-stop ultrafast laser fabrication approach for development of micro/nano patterns, then producing bactericidal thin film through depositing metal nanoparticles on those micro/nano patterned surfaces. The combination of bacterial anti-adhesion and bactericidal film can inhibit initial bacterial adhesion and release heavy metal ions to kill the bacteria simultaneously. Meanwhile, the multi-functional surface with self-cleaning function can prevent the killed bacteria from accumulating at the substrate surface, thereby obtaining long-lasting antibacterial effect.

Abstract: A method of preparing antimicrobial surface on medical devices: first, producing multi-functional surface with bacterial anti-adhesion and self-cleaning functions through single-stop ultrafast laser fabrication approach for development of micro/nano patterns, then producing bactericidal thin film through depositing metal nanoparticles on those micro/nano patterned surfaces. The combination of bacterial anti-adhesion and bactericidal film can inhibit initial bacterial adhesion and release heavy metal ions to kill the bacteria simultaneously. Meanwhile, the multi-functional surface with self-cleaning function can prevent the killed bacteria from accumulating at the substrate surface, thereby obtaining long-lasting antibacterial effect.

Abstract: The present invention disclosed a method for fabrication of fluorescence-Raman dual enhanced modal biometal substrate. The method comprises the steps of grinding surface of the substrate with different types of sandpapers to remove an oxide layer and smooth the surface of the substrate; wherein a roughness of the surface is less than 0.1 ?m; cleaning the grinded substrate in an ultrasonic bath to remove any impurity; placing the specimen on the stage of an ultrashort laser system; processing the specimen at a certain laser processing parameters by a galvanometer; finally, three-dimensional micro-nano structure is fabricated on the specimen. The technique of the present invention is promising for large-scale commercial application because it is simple and economical, while the enhanced Raman and fluorescence signal is stable and high reproducibility.