Abstract: This application discloses a speech signal processing method, a neural network training method, and a device, which are applied to the signal processing field, includes: obtaining a first bone conduction speech signal, extracting an excitation parameter from the first bone conduction speech signal, and determining a first transfer function corresponding to the first bone conduction speech signal; then inputting the first transfer function into a trained neural network to obtain a second transfer function (that is, a predicted transfer function of an air conduction speech signal), where the trained neural network is obtained by training a neural network based on a target loss function by using a training dataset; and finally obtaining, based on the second transfer function and the excitation parameter, a first air conduction speech signal corresponding to the first bone conduction speech signal.

Abstract: Embodiments of this application disclose a bone conduction microphone, a headphone, and a call apparatus. The bone conduction microphone includes a sound pickup, a vibration obtaining component, and a noise reduction component. The noise reduction component includes a first dielectric layer and a second dielectric layer that are stacked. The first dielectric layer and the second dielectric layer are made of elastic materials, and cover another surface of the sound pickup other than a sound pickup surface, and an opening is disposed at one end corresponding to the sound pickup surface. The vibration obtaining component includes a third dielectric layer. The third dielectric layer is disposed at a layer of the sound pickup close to the sound pickup surface, and seals the opening end of the first dielectric layer. A contact surface between the first dielectric layer and the second dielectric layer is a rough contact surface.

Abstract: A headset has a first bone conduction microphone and a second bone conduction microphone. The first bone conduction microphone is attached to a head in a worn state. A first vibration signal collected by the first bone conduction microphone mainly includes a human voice signal and an ambient noise signal. The second bone conduction microphone is coupled to a fastener via a first flexible connection structure, and the second bone conduction microphone is separated from the head in the worn state. A second vibration signal collected by the second bone conduction microphone mainly includes the ambient noise signal. A controller in the headset can perform noise reduction processing on the first vibration signal based on the second vibration signal.

Abstract: A speech signal processing method and a related device thereof are provided. The method may be applied to the audio field and includes: obtaining a user speech signal captured by a sensor; obtaining a corresponding vibration signal when a user generates a speech, where the vibration signal indicates a vibration feature of a body part of the user, and the body part is a part that vibrates correspondingly based on sound-making behavior when the user is making a sound; and obtaining target speech information based on the vibration signal and the user speech signal captured by the sensor. In this application, the vibration signal is used as a basis for speech recognition.

Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1. The photolithographic coating is exposed to a light having a first wavelength, to image the to-be-connected structure to a first region of the photolithographic film. The photolithographic coating is exposed to a light having a second wavelength through a mask, to image the mask to a second region of the photolithographic film. A region in which the first region and the second region overlap serves as a connection region corresponding to the to-be-connected structure, and thereby self-alignment between a layer of the to-be-connected structure and a layer where a contact hole is arranged is implemented.

Abstract: The present disclosure provides a method for optimizing mask parameters, and the method includes: acquiring a test pattern, light source parameters, and initial mask parameters, the initial mask parameters including a mask thickness and an initial mask sidewall angle; generating multiple sets of candidate mask parameters according to the initial mask sidewall angle in the initial mask parameters; the multiple sets of candidate mask parameters including different mask sidewall angles and the same mask thickness; obtaining an imaging contrast of each set of candidate mask parameters based on the test pattern and the light source parameters; and selecting an optimal mask sidewall angle from the multiple sets of candidate mask parameters according to the imaging contrasts.

Abstract: The present invention relates to the field of solid-phase extraction, and particularly to a solid-phase extraction material, and a preparation method and use thereof. The preparation method includes prepolymerizing the monomers N-vinylpyrrolidone and divinylbenzene in the presence of a chain transfer agent, adding prepolymer dropwise to an emulsion of monodispersed seed microspheres, swelling, and reacting to prepare white spheres; and functionalizing the white spheres, to obtain the solid-phase extraction material. The solid-phase extraction material prepared by the reaction has good spherical morphology, large specific surface area, and high ion exchange capacity. The prepared solid-phase extraction material functions in the separation and enrichment of PPCPs by means of a variety of forces with a high extraction rate. The extraction rate is basically maintained between 85% and 105%, and acidic, alkaline, neutral and amphoteric substances is capable of being selectively separated.

Abstract: Compositions comprising mRNA, self-amplifying mRNA (sa-mRNA), modified mRNA, or circular RNA constructs comprising a gene-of-interest, and lipids and LNPs for use in therapy are disclosed. A method of delivering a payload to immune cells ex vivo by contacting immune cells with a lipid nanoparticle (LNP) encapsulating a payload encoding at least one polypeptide of interest, wherein the polypeptide of interest is an antigen receptor or an antibody.

Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1, so that the photolithographic coating forms an optical structure with a high reflection coefficient. The photolithographic coating is exposed to a light having a target wavelength through a mask. The to-be-connected structure is reflected in the photolithographic coating, and hence serves as another mask and is imaged to the photolithographic film. A pattern of the mask is simultaneously imaged to the photolithographic film. That is, both the to-be-connected structure and the pattern of the mask are imaged to a target region of the photolithographic film, and the target region corresponds to the to-be-connected structure.

Abstract: Embodiments of the present disclosure provide a headset control method, a headset, a headset control apparatus, and a related storage medium. The method includes: collecting environment information, and determining key sound detection sensitivity based on the environment information; performing key sound detection in the environment information based on the key sound detection sensitivity; and if a key sound exists in the environment information, adjusting the headset to a hear through mode, or playing the key sound. The headset collects the environment information, determines the key sound detection sensitivity based on the environment information, and performs key sound detection in the environment information based on the key sound detection sensitivity. If the key sound exists, the headset is adjusted to the hear through mode, or the key sound is played.

Abstract: Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA, compositions, and methods of using the novel nucleic acid constructs and compositions are disclosed. LNP constructs include novel ionizable lipid. Novel sa-mRNA constructs encode a modified SARS-COV-2 spike protein, wherein the polynucleotide has been truncated to not include nucleotides encoding a SARS-COV-2 transmembrane domain and short cytosolic domain amino acids and immunomodulators. Sa-mRNAs are useful in for use as a therapeutic, diagnostic and/or prophylactic agent to mammalian cells or organs.

Abstract: A video coding method includes: obtaining a first video file and a second video file that are different; separately decoding the first video file and the second video file to obtain first information of a first image block in the first video file and second information of a second image block in the second video file; obtaining, based on the first information and the second information, difference information indicating a difference between the first information and the second information; and encoding the difference information to obtain encoded data. The difference information may be used to replace an original decoding result in the second video file. It is equivalent to reducing storage resources for video storage and bandwidth for video transmission while ensuring that the complete second video file can be restored.

Abstract: Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA, compositions, and methods of using the novel nucleic acid constructs and compositions are disclosed. LNP constructs include novel ionizable lipid. Novel sa-mRNA constructs encode a modified SARS-CoV-2 spike protein, wherein the polynucleotide has been truncated to not include nucleotides encoding a SARS-CoV-2 transmembrane domain and short cytosolic domain amino acids and immunomodulators. Sa-mRNAs are useful in for use as a therapeutic, diagnostic and/or prophylactic agent to mammalian cells or organs.

Abstract: The present invention belongs to the field of printing, and specifically relates to a method for acquiring a color density characteristic curve in printing, including: designing a standard N-color level image of a single color channel; performing printout and scan correction on the standard N-color level image; performing edge finding operation on a corrected image; dividing the image into regions; and calculating a deviation. According to the method for acquiring a color density characteristic curve in printing by channels provided by the present invention, the color density characteristic curve of all the color channels may be obtained by sequentially using the method in the present invention on the color channels. The method in the present invention provides a basis for studying the performance of a printing system and further solving the problem of color density characteristic deviations at different positions.

Abstract: Novel delivery nanoparticles composes of two-, or three-component lipid compounds. Compositions comprising such lipid compounds, and related methods of their use are disclosed. Nanoparticle compositions include at least one novel modular lipid as well as additional lipids such as ionizable lipids, and phospholipids. Nanoparticle compositions further including biologically active agents, such as siRNA or mRNA, are useful in the delivery of said biologically active agents to subjects in need thereof.

Abstract: The present invention relates to the field of solid-phase extraction, and particularly to a solid-phase extraction material, and a preparation method and use thereof. The preparation method includes prepolymerizing the monomers N-vinylpyrrolidone and divinylbenzene in the presence of a chain transfer agent, adding prepolymer dropwise to an emulsion of monodispersed seed microspheres, swelling, and reacting to prepare white spheres; and functionalizing the white spheres, to obtain the solid-phase extraction material. The solid-phase extraction material prepared by the reaction has good spherical morphology, large specific surface area, and high ion exchange capacity. The prepared solid-phase extraction material functions in the separation and enrichment of PPCPs by means of a variety of forces with a high extraction rate. The extraction rate is basically maintained between 85% and 105%, and acidic, alkaline, neutral and amphoteric substances is capable of being selectively separated.

Abstract: The present disclosure provides a method for optimizing mask parameters, and the method includes: acquiring a test pattern, light source parameters, and initial mask parameters, the initial mask parameters including a mask thickness and an initial mask sidewall angle; generating multiple sets of candidate mask parameters according to the initial mask sidewall angle in the initial mask parameters; the multiple sets of candidate mask parameters including different mask sidewall angles and the same mask thickness; obtaining an imaging contrast of each set of candidate mask parameters based on the test pattern and the light source parameters; and selecting an optimal mask sidewall angle from the multiple sets of candidate mask parameters according to the imaging contrasts.

Abstract: Provided is a method for correcting a lithography pattern of a surface plasma, including: forming a plurality of test patterns on a test mask; exposing a photoresist layer by using the test mask containing the test patterns to form a plurality of photoresist patterns; establishing a first data table based on a correspondence between the first test parameter and the second test parameter of the test pattern and the first exposure parameter and the second exposure parameter of the photoresist pattern; processing the first data table according to the first exposure parameter to obtain a second data table; and respectively correcting second test parameters of a plurality of design patterns according to the second data table to obtain corrected design patterns, and manufacturing a mask for exposure by using the corrected design patterns.

Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1, so that the photolithographic coating forms an optical structure with a high reflection coefficient. The photolithographic coating is exposed to a light having a target wavelength through a mask. The to-be-connected structure is reflected in the photolithographic coating, and hence serves as another mask and is imaged to the photolithographic film. A pattern of the mask is simultaneously imaged to the photolithographic film. That is, both the to-be-connected structure and the pattern of the mask are imaged to a target region of the photolithographic film, and the target region corresponds to the to-be-connected structure.

Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1. The photolithographic coating is exposed to a light having a first wavelength, to image the to-be-connected structure to a first region of the photolithographic film. The photolithographic coating is exposed to a light having a second wavelength through a mask, to image the mask to a second region of the photolithographic film. A region in which the first region and the second region overlap serves as a connection region corresponding to the to-be-connected structure, and thereby self-alignment between a layer of the to-be-connected structure and a layer where a contact hole is arranged is implemented.