Abstract: Novel ionizable lipids, compositions, and methods of using the novel ionizable lipids and compositions are disclosed. Lipid nanoparticle compositions include a novel ionizable lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticle compositions further including biologically active agents such as mRNA or DNA are useful in the delivery of biologically active agents to mammalian cells or organs.

Abstract: A music recommendation method and apparatus are provided, to determine an attention mode of a user in a complex environment by using viewpoint information of the user, thereby more precisely implementing music matching. According to a first aspect, a music recommendation method is provided. The method includes: receiving visual data of a user (S501); obtaining at least one attention unit and attention duration of the at least one attention unit based on the visual data (S502); determining an attention mode of the user based on the attention duration of the at least one attention unit (S503); and determining recommended music information based on the attention mode (S504).

Abstract: A self-excitation lithography method with a self-alignment effect. During the first lithography processing, the first mask is used merely to define an effective lithography region for the second lithography processing. Therefore, the first mask may be of a relatively large size, thereby greatly reducing the manufacturing difficulty of the first mask. Since the first metal layer and the second metal layer are both material layers having a negative refractive index, and a thickness difference exists in the second photoresist layer respectively corresponding to the first metal layer and the second metal layer, after performing simulation and optimization, resolution enhancement can be achieved in the region corresponding to the protruding structure, thereby realizing a self-alignment lithographic-pattern imaging with the self-excitation effect only in the region corresponding to the protruding structure.

Abstract: A method and a structure for lithography alignment. The method comprises: providing a first structure comprising a substrate and a mask layer located at a side of the substrate, a first pattern in the mask layer comprising a first groove, a second pattern serving as an alignment mark in the mask layer for lithography comprising a second groove; forming a metal layer filling the first groove fully and covering a sidewall and a bottom surface of the second groove, a thickness of the metal layer at the bottom surface of the second groove being less than a depth of the second groove; forming a first non-transparent layer having a first recess over the second pattern; forming a photoresist layer with a surface parallel to a surface of the substrate; and forming a second non-transparent layer with a surface parallel to the surface of the substrate.

Abstract: The present disclosure provides a facility, including a water flow control device and an aquaculture device, where the water flow control device includes a sieve, a gate and a drain pipe, and the aquaculture device includes a longitudinal stepped aquaculture pond, a transverse stepped aquaculture pond, and tile adhesion bases. The longitudinal stepped aquaculture pond is provided with the sieve at a water inlet end and the drain pipe at a water outlet end. The transverse stepped aquaculture pond is provided on a side of the longitudinal stepped aquaculture pond, the gate is provided between a water inlet end of the transverse stepped aquaculture pond and the longitudinal stepped aquaculture pond, the transverse stepped aquaculture pond is provided with the drain pipe at a position away from the gate, and the tile adhesion bases are provided on bottoms of both the longitudinal stepped aquaculture pond and the transverse stepped aquaculture pond.

Abstract: Compositions comprising mRNA, self-amplifying mRNA (sa-mRNA), modified mRNA, or circular RNA constructs comprising a gene-of-interest, and lipids and LNPs for use in therapy are disclosed. A method of delivering a payload to immune cells ex vivo by contacting immune cells with a lipid nanoparticle (LNP) encapsulating a payload encoding at least one polypeptide of interest, wherein the polypeptide of interest is an antigen receptor or an antibody.

Abstract: A device enabling method and apparatus, and a storage medium relate to: collecting at least two types of biometric feature information of a user; performing identity authentication on the user based on the at least two types of biometric feature information; and if identity authentication succeeds, enabling at least one of a wearable device and a smart device, where the wearable device is communicatively connected to the smart device. This disclosure helps ensure information security of a device.

Abstract: The present discloser relates to a method for active noise cancellation. An example method includes: capturing an ambient sound to determine an ambient audio signal; and determining a working status, determining at least one corresponding wanted signal based on the working status, and then removing the at least one wanted signal from the ambient audio signal, to obtain a reference signal, where the wanted signal includes content of interest. The example method further includes determining a to-be-played signal based on the reference signal.

Abstract: Embodiments of this disclosure provide a device operation method and apparatus, and an electronic device. In the device operation method, after obtaining a vibration signal collected by a bone conduction microphone connected to the electronic device, the electronic device extracts a vibration signal feature of the vibration signal, and then compares the extracted vibration signal feature with a control feature stored in the electronic device. When a comparison result is that the extracted vibration signal feature matches the control feature, the electronic device performs an operation corresponding to the control feature. The vibration signal collected by the bone conduction microphone may be a bone conduction audio signal, and the bone conduction audio signal is skin vibration triggered when a nasal cavity and/or a throat of a user who uses the electronic device make/makes a specific sound.

Abstract: A vehicle wheel end sub-assembly includes a wheel bearing unit configured to be assembled on a vehicle stub axle, and a wheel adapter rotatably supported on the stub axle via the wheel bearing unit. The wheel bearing unit includes two rows of bearings and an outer ring integral member, and the wheel adapter is releasably connected to the outer ring integral member at at least one screw fastening point by at least one threaded fastener and is configured to connect a brake disk to a wheel. The at least one screw fastening point is located at a radial periphery of the outer ring integral member at a location axially spaced from an outboard end face of the outer ring integral member.

Abstract: An anode active material for a sodium ion energy storage device with improved volumetric capacity, capacity retention, and coulombic efficiency and the method thereof is disclosed. The anode active material comprises an alloying element. The anode active material may further comprise a carbon active material. The alloying element may be selected from phosphorus (P), germanium (Ge), tin (Sn), antimony (Sb), lead (Pb), and bismuth (Bi). The anode comprising the anode active material shows improved capacity retention.

Abstract: A signal processing apparatus is configured to preprocess a sound wave signal and output a processed audio signal through an electromagnetic wave. The signal processing apparatus includes: a receiving unit, configured to receive at least one sound wave signal; a conversion unit, configured to convert the at least one sound wave signal to at least one audio signal; a positioning unit, configured to determine position information related to the at least one sound wave signal; a processing unit, configured to determine a sending time point of at least one audio signal based on the position information and a first time point, where the first time point is a time point at which the receiving unit receives the at least one sound wave signal; and a sending unit, configured to send the at least one audio signal through the electromagnetic wave.

Abstract: Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA, compositions, and methods of using the novel nucleic acid constructs and compositions are disclosed. LNP constructs include novel ionizable lipid. Novel sa-mRNA constructs encode a modified SARS-COV-2 spike protein, wherein the polynucleotide has been truncated to not include nucleotides encoding a SARS-COV-2 transmembrane domain and short cytosolic domain amino acids and immunomodulators. Sa-mRNAs are useful in for use as a therapeutic, diagnostic and/or prophylactic agent to mammalian cells or organs.

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncolytic defective virus compositions and methods of in vivo synthesis thereof. The composition includes a first nucleic acid construct encoding a self-amplifying mRNA (sa-mRNA) encoding at least one gene of interest (GOI) or a plurality of GOIs, a second nucleic acid construct encoding an mRNA encoding at least one virus structural protein, and at least one payload delivery system.

Abstract: This application discloses a speech signal processing method, a neural network training method, and a device, which are applied to the signal processing field, includes: obtaining a first bone conduction speech signal, extracting an excitation parameter from the first bone conduction speech signal, and determining a first transfer function corresponding to the first bone conduction speech signal; then inputting the first transfer function into a trained neural network to obtain a second transfer function (that is, a predicted transfer function of an air conduction speech signal), where the trained neural network is obtained by training a neural network based on a target loss function by using a training dataset; and finally obtaining, based on the second transfer function and the excitation parameter, a first air conduction speech signal corresponding to the first bone conduction speech signal.

Abstract: Embodiments of this application disclose a bone conduction microphone, a headphone, and a call apparatus. The bone conduction microphone includes a sound pickup, a vibration obtaining component, and a noise reduction component. The noise reduction component includes a first dielectric layer and a second dielectric layer that are stacked. The first dielectric layer and the second dielectric layer are made of elastic materials, and cover another surface of the sound pickup other than a sound pickup surface, and an opening is disposed at one end corresponding to the sound pickup surface. The vibration obtaining component includes a third dielectric layer. The third dielectric layer is disposed at a layer of the sound pickup close to the sound pickup surface, and seals the opening end of the first dielectric layer. A contact surface between the first dielectric layer and the second dielectric layer is a rough contact surface.

Abstract: A headset has a first bone conduction microphone and a second bone conduction microphone. The first bone conduction microphone is attached to a head in a worn state. A first vibration signal collected by the first bone conduction microphone mainly includes a human voice signal and an ambient noise signal. The second bone conduction microphone is coupled to a fastener via a first flexible connection structure, and the second bone conduction microphone is separated from the head in the worn state. A second vibration signal collected by the second bone conduction microphone mainly includes the ambient noise signal. A controller in the headset can perform noise reduction processing on the first vibration signal based on the second vibration signal.

Abstract: A speech signal processing method and a related device thereof are provided. The method may be applied to the audio field and includes: obtaining a user speech signal captured by a sensor; obtaining a corresponding vibration signal when a user generates a speech, where the vibration signal indicates a vibration feature of a body part of the user, and the body part is a part that vibrates correspondingly based on sound-making behavior when the user is making a sound; and obtaining target speech information based on the vibration signal and the user speech signal captured by the sensor. In this application, the vibration signal is used as a basis for speech recognition.

Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1. The photolithographic coating is exposed to a light having a first wavelength, to image the to-be-connected structure to a first region of the photolithographic film. The photolithographic coating is exposed to a light having a second wavelength through a mask, to image the mask to a second region of the photolithographic film. A region in which the first region and the second region overlap serves as a connection region corresponding to the to-be-connected structure, and thereby self-alignment between a layer of the to-be-connected structure and a layer where a contact hole is arranged is implemented.

Abstract: The present disclosure provides a method for optimizing mask parameters, and the method includes: acquiring a test pattern, light source parameters, and initial mask parameters, the initial mask parameters including a mask thickness and an initial mask sidewall angle; generating multiple sets of candidate mask parameters according to the initial mask sidewall angle in the initial mask parameters; the multiple sets of candidate mask parameters including different mask sidewall angles and the same mask thickness; obtaining an imaging contrast of each set of candidate mask parameters based on the test pattern and the light source parameters; and selecting an optimal mask sidewall angle from the multiple sets of candidate mask parameters according to the imaging contrasts.