Patents by Inventor Libin ZONG

Libin ZONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof
    Patent number: 11608334
    Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: March 21, 2023
    Assignee: THE NATIONAL INSTITUTES OF PHARMACEUTICAL R&D CO., LTD.
    Inventors: Huijun Yin, Xu Yan, Libin Zong, Weixue Tian, Li Zheng, Haoshuai Dou, Yan Yang
  • AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
    Publication number: 20220127258
    Abstract: The present invention relates to aromatic ring or heteroaromatic ring compounds, a preparation method therefor and a medical use thereof. Particularly, the present invention relates to a compound as shown in general formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound and a use thereof as an agonist for a farnesoid X receptor (FXR). The compound and the pharmaceutical composition comprising the compound can be used for treating and/or preventing FXR activity-related diseases, for example, cholestatic symptoms, diabetes and complications thereof, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatosis heptitis (NASH), obesity or metabolic syndrome (diseases associated with dyslipidemia, diabetes, abnormally high body weight index), cardiovascular diseases and so on. The definition of each substituent in the general formula (I) is the same as that in the description.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 28, 2022
    Inventors: Huijun YIN, Xu YAN, Libin ZONG, Jianxin SHI, Chunyan LIU, Shouliang ZHANG, Jiawei LU, Hao LI
  • PYRROLO-AROMATIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Publication number: 20200062749
    Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.
    Type: Application
    Filed: December 26, 2017
    Publication date: February 27, 2020
    Applicant: The National Institutes of Pharmaceutical Research and Development (NIP)
    Inventors: Huijun YIN, Xu YAN, Libin ZONG, Weixue TIAN, Li ZHENG, Haoshuai DOU, Yan YANG