Patents by Inventor Libing Chen

Libing Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS
    Publication number: 20140179674
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Inventors: Brian E. Fink, Libing Chen, Ashvinikumar V. Gavai, Liqi He, Soong-Hoon Kim, Andrew James Nation, Yufen Zhao, Litai H. Zhang
  • Substituted imidazopyridazines useful as kinase inhibitors
    Patent number: 8389527
    Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: March 5, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Brian E. Fink, Soong-Hoon Kim, Yufen Zhao, Ping Chen, Wayne Vaccaro, Litai Zhang, Ashvinikumar V Gavai, Dharmpal S Dodd, Libing Chen
  • IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS
    Publication number: 20120283241
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Application
    Filed: July 19, 2012
    Publication date: November 8, 2012
    Inventors: Brian E. Fink, Libing Chen, Ashvinikumar V. Gavai, Liqi He, Soong-Hoon Kim, Andrew James Nation, Yufen Zhao, Litai H. Zhang
  • Imidazopyridazinecarbonitriles useful as kinase inhibitors
    Patent number: 8252795
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: August 28, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Brian E. Fink, Libing Chen, Ashvinikumar V. Gavai, Liqi He, Soong-Hoon Kim, Andrew James Nation, Yufen Zhao, Litai H. Zhang
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 7906653
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: March 15, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Louis-David Cantin, Soongyu Choi, Roger B. Clark, Martin F. Hentemann, Xin Ma, Joachim Rudolph, Sidney X. Liang, Christiana Akuche, Rico C. Lavoie, Libing Chen, Dyuti Majumdar, Philip L. Wickens
  • SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS
    Publication number: 20100323994
    Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Application
    Filed: February 6, 2009
    Publication date: December 23, 2010
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Brian E. Fink, Soong-Hoon Kim, Yufen Zhao, Ping Chen, Wayne Vaccaro, Litai Zhang, Ashvinikumar V. Gaval, Dharmpal S. Dodd, Libing Chen
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20100204472
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: April 13, 2010
    Publication date: August 12, 2010
    Inventors: Louis-David Cantin, Soongyu Choi, Roger B. Clark, Martin F. Hentemann, Xin Ma, Joachim Rudolph, Sidney X. Liang, Christiana Akuche, Rico C. Lavoie, Libing Chen, Dyuti Majumdar, Philip L. Wickens
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 7714004
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: May 11, 2010
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Louis-David Cantin, Soongyu Choi, Roger B. Clark, Martin F. Hentemann, Xin Ma, Joachim Rudolph, Sidney X. Liang, Christiana Akuche, Rico C. Lavoie, Libing Chen, Dyuti Majumdar, Philip L. Wickens
  • IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS
    Publication number: 20100113458
    Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
    Type: Application
    Filed: October 8, 2009
    Publication date: May 6, 2010
    Inventors: Brian E. Fink, Libing Chen, Ashvinikumar V. Gavai, Liqi He, Soong-Hoon Kim, Andrew James Nation, Yufen Zhao, Litai H. Zhang
  • HETEROARYLAMINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES
    Publication number: 20090209451
    Abstract: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Application
    Filed: April 13, 2009
    Publication date: August 20, 2009
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Joachim Rudolph, Phillip Wickens, Chih-Yuan Chuang, Libing Chen, Steven Magnuson, Alan Olague, Ning Qi
  • Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
    Patent number: 7517878
    Abstract: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: April 14, 2009
    Assignee: Bayer Pharamceuticals Corporation
    Inventors: Joachim Rudolph, Philip Wickens, Chih-Yuan Chuang, Libing Chen, Steven Magnuson, Alan Olague, Ning Qi
  • Anilinopyrazole derivatives useful for the treatment of diabetes
    Publication number: 20080064734
    Abstract: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Application
    Filed: August 31, 2007
    Publication date: March 13, 2008
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Joachim Rudolph, Louis-David Cantin, Steven Magnuson, William Bullock, Ann-Marie Bullion, Libing Chen, Chih-Yuan Chuang, Sidney Liang, Dyuti Majumdar, Herbert Ogutu, Alan Olague, Ning Qi, Philip Wickens
  • Anilinopyrazole derivatives useful for the treatment of diabetes
    Patent number: 7265144
    Abstract: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: September 4, 2007
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Joachim Rudolph, Louis-David Cantin, Steven Magnuson, William Bullock, Ann-Marie Bullion, Libing Chen, Chih-Yuan Chuang, Sidney Liang, Dyuti Majumdar, Herbert Ogutu, Alan Olague, Ning Qi, Philip L. Wickens
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20060084680
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: December 19, 2003
    Publication date: April 20, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Xin Ma, Joachim Rudolph, Sidney Liang, Christiana Akuche, Rico Lavoie, Libing Chen, Dyuti Majumdar, Philip Wickens
  • 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders
    Patent number: 6964971
    Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: November 15, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Yamin Wang, William H. Bullock, Libing Chen
  • Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
    Publication number: 20050192294
    Abstract: The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Application
    Filed: February 24, 2005
    Publication date: September 1, 2005
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Joachim Rudolph, Philip Wickens, Chih-Yuan Chuang, Libing Chen, Steven Magnuson, Alan Olague, Ning Qi
  • 1, 6-Naphthyridine derivatives and their use to treat diabetes and related disorders
    Publication number: 20040157875
    Abstract: The invention relates generally to naphthyridine derivatives of the formula 1
    Type: Application
    Filed: October 10, 2003
    Publication date: August 12, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Yamin Wang, William H. Bullock, Libing Chen
  • Anilinopyrazole derivatives useful for the treatment of diabetes
    Publication number: 20040157904
    Abstract: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
    Type: Application
    Filed: November 21, 2003
    Publication date: August 12, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Joachim Rudolph, Louis-David Cantin, Steven Magnuson, William Bullock, Ann-Marie Bullion, Libing Chen, Chih-Yuan Chuang, Sidney Liang, Dyuti Majumdar, Herbert Ogutu, Alan Olague, Ning Qi, Philip L. Wickens
  • 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders
    Patent number: 6677352
    Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: January 13, 2004
    Inventors: Yamin Wang, William H. Bullock, Libing Chen