Abstract: An acid-base neutralization combination can be used as a local active ingredient in a local medicine for the treatment of a local lesion disease. A local pharmaceutical composition can include the combination, and a method for treating a local lesion disease can include administering the pharmaceutical composition. The acid-base neutralization combination can include an acidifying agent and a corresponding pH neutralizing agent, or a basifying agent and a corresponding pH neutralizing agent.

Abstract: A local pharmaceutical composition includes a probiotic component. The probiotic component can be included as an active ingredient for the treatment of local lesion diseases. The local composition provides a unique pharmacology that realizes chemical ablation-like local treatment and achieves a local effect (or local synergy) and/or immunotherapy. The immunotherapy includes a secondary immunological effect associated with the local effect (or local synergy), which cannot be achieved by existing probiotic compositions. The local composition has almost completely non-toxic systemic safety and a significantly higher long-term efficacy than other compositions. The composition can treat rapidly growing tumors, large tumors and hypovascular tumors, and is absent of drug resistance. The composition is convenient to prepare and has low costs.

Abstract: A pharmaceutical composition including a high concentration amino acid nutrient and a synergist thereof, an apparatus including said composition, and a use of said composition in preparing a pharmaceutical composition which treats topical lesion diseases.