Patents by Inventor LiChung Ma

LiChung Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NMR ASSAY TO SCREEN PROTEIN-PROTEIN INTERACTION INHIBITORS
    Publication number: 20160041181
    Abstract: This invention relates generally to a field of rational drug design. In particular, the present invention relates to a 19 F NMR assay for screening inhibitors of specific protein-target interactions, preferably those that inhibit influenza A NS 1 protein and can be useful in treating influenza A viral infections. The invention also relates to agents, compositions, and methods for treating influenza A viral infections.
    Type: Application
    Filed: February 4, 2014
    Publication date: February 11, 2016
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Gaetano T. Montelione, Patrick L. Nosker, Vikas Nanda, James M. Aramini, Douglas Pike, Lichung Ma, Keith Hamilton, Srinivas Annavarapu
  • Influenza A virus vaccines and inhibitors
    Patent number: 8455621
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: June 4, 2013
    Assignees: Rutgers, The State University of New Jersery, Board of Regents, The University of Texas System
    Inventors: Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo, Gaetano Montelione, Edward Arnold, Kalyan Das, LiChung Ma, Rong Xiao
  • Influenza A Virus Vaccines and Inhibitors
    Publication number: 20100247569
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Application
    Filed: February 17, 2010
    Publication date: September 30, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • Influenza A virus vaccines and inhibitors
    Patent number: 7709190
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Grant
    Filed: December 2, 2006
    Date of Patent: May 4, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo
  • INFLUENZA A VIRUS VACCINES AND INHIBITORS
    Publication number: 20080108050
    Abstract: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
    Type: Application
    Filed: December 2, 2006
    Publication date: May 8, 2008
    Inventors: Gaetano Montelione, Kalyan Das, Edward Arnold, LiChung Ma, Rong Xiao, Robert M. Krug, Karen Y. Twu, Rei-Lin Kuo