Patents by Inventor Licong Jiang

Licong Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID DOSAGE FORMS AND DOSING REGIMENS COMPRISING (2R,3S,4S,5R)-4-[[3-(3,4-DIFLUORO-2-METHOXY-PHENYL)-4,5-DIMETHYL-5-(TRIFLUOROMETHYL) TETRAHYDROFURAN-2-CARBONYL]AMINO]PYRIDINE-2-CARBOXAMIDE
    Publication number: 20240285596
    Abstract: Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide (Compound 1), defined as described herein, or a pharmaceutically acceptable salt thereof and a tablet containing the solid dispersion for treating pain. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.
    Type: Application
    Filed: June 3, 2022
    Publication date: August 29, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Radhika KARKARE, Cathy CHU, Brenda CIRINCIONE, Darin J. CORRELL, Philip Kaj Harder DELFF, Kirk Raymond DINEHART, Paloma BENITO GALLO, Tanya Louise HAY, Licong JIANG, James B. JONES, Katie L. MCCARTY, Catherine P. METZLER, Jonathan M. MILLER, Mark C. PETERSON, Rahul ROOPWANI, John F. STAROPOLI
  • Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
    Patent number: 11358977
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. The compounds have the formula (I) wherein R is H or CH2OPO(OH)2. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: June 14, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Licong Jiang, Sara Sabina Hadida Ruah
  • DEUTERATED PYRIDONE AMIDES AND PRODRUGS THEREOF AS MODULATORS OF SODIUM CHANNELS
    Publication number: 20210155643
    Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. The compounds have the formula (I) wherein R is H or CH2OPO(OH)2. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
    Type: Application
    Filed: May 16, 2018
    Publication date: May 27, 2021
    Inventors: Licong JIANG, Sara Sabina HADIDA RUAH
  • Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels
    Publication number: 20170145011
    Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: December 5, 2016
    Publication date: May 25, 2017
    Inventors: Sara Sabina HADIDA RUAH, Edward Adam KALLEL, Mark Thomas MILLER, Vijayalaksmi ARUMUGAM, Jason McCARTNEY, Corey ANDERSON, Peter Diederik Jan GROOTENHUIS, Licong JIANG
  • Substituted spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]s as modulators of ion channels
    Patent number: 9511067
    Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: December 6, 2016
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Sara Sabina Hadida Ruah, Edward Adam Kallel, Mark Thomas Miller, Vijayalaksmi Arumugam, Jason McCartney, Corey Anderson, Peter Diederik Jan Grootenhuis, Licong Jiang
  • MODULATORS FOR ATP-BINDING CASSETTE TRANSPORTERS
    Publication number: 20160166540
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: January 11, 2016
    Publication date: June 16, 2016
    Inventors: Adam Looker, Benjamin Joseph Littler, Anusuya Choudhury, Christian Harrison, Ravikanth Veluri, Michael P. Ryan, Licong Jiang, Eduard Luss-Lusis
  • Modulators of ATP-binding cassette transporters
    Patent number: 9254291
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: February 9, 2016
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Adam Looker, Benjamin Joseph Littler, Anusuya Choudhury, Cristian Harrison, Ravikanth Veluri, Michael P. Ryan, Licong Jiang, Eduard Luss-Lusis
  • Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels
    Publication number: 20150174127
    Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: December 22, 2014
    Publication date: June 25, 2015
    Inventors: Sara Sabina HADIDA RUAH, Edward Adam KALLEL, Mark Thomas MILLER, Vijayalaksmi ARUMUGAM, Jason McCARTNEY, Corey ANDERSON, Peter Diederik Jan GROOTENHUIS, Licong JIANG
  • Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
    Patent number: 8916565
    Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds of formula (I) useful as inhibitors of ion channels: wherein R1, R2, R3, R4, A, m, n, and o are as defined in the description. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: December 23, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Sabina Hadida Ruah, Edward Adam Kallel, Mark Thomas Miller, Vijayalaksmi Arumugam, Jason McCartney, Corey Anderson, Peter Diederik Jan Grootenhuis, Licong Jiang
  • PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
    Publication number: 20120196869
    Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 2, 2012
    Inventors: Sara Sabina Hadida Ruah, Edward Adam Kallel, Mark Thomas Miller, Vijayalaksmi Arumugam, Jason McCartney, Corey Anderson, Peter Diederik Jan Grootenhuis, Licong Jiang