Patents by Inventor Lidai Wang

Lidai Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12193791
    Abstract: A handheld device for photoacoustic microscopy. The handheld device includes an optical assembly, a light beam scanner and a transducer unit. The optical assembly is arranged to provide a light beam. The light beam scanner includes a reflector arranged to reflect the light beam from the optical assembly to provide a reflected light beam to an object, a first drive mechanism operable to move the reflector relative to the optical assembly to move the reflected light beam relative to the object, and a second drive mechanism operable to move the reflector relative to the optical assembly to move the reflected light beam relative to the object. The transducer unit is arranged to detect photoacoustic signals emitted by the object in response to receiving the reflected light beam.
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: January 14, 2025
    Assignee: City University of Hong Kong
    Inventors: Lidai Wang, Jiangbo Chen
  • Publication number: 20240405504
    Abstract: An optical radiation modulation device that includes two or more optical fibers arranged optically in parallel, a first coupler coupled with the optical fibers, and a second coupler coupled with the optical fibers. The first coupler is operable to receive a single-wavelength optical radiation and to provide or distribute the single-wavelength optical radiation to the optical fibers. The second coupler is operable to receive optical radiations outputted by the optical fibers. The optical fibers include, at least: a first optical fiber operable to modulate the single-wavelength optical radiation provided or distributed to the first optical fiber to generate a multi-wavelength optical radiation for output to the second coupler; and a second optical fiber.
    Type: Application
    Filed: May 30, 2023
    Publication date: December 5, 2024
    Inventors: Lidai Wang, Jiangbo Chen
  • Publication number: 20240041436
    Abstract: A system for processing photoacoustic and ultrasound imaging data includes processor(s) and memory storing program(s) configured to be executed by the processor(s). The program(s) include instructions for: obtaining ultrasound imaging data representative of an ultrasound image of the object, performing a speed of sound value optimization operation based on the ultrasound imaging data for facilitating image reconstruction, and performing an image reconstruction operation. The ultrasound imaging data is obtained from a system for photoacoustic imaging and ultrasound imaging.
    Type: Application
    Filed: August 2, 2022
    Publication date: February 8, 2024
    Inventors: Lidai Wang, Yachao Zhang
  • Publication number: 20240041329
    Abstract: A handheld device for photoacoustic microscopy. The handheld device includes an optical assembly, a light beam scanner and a transducer unit. The optical assembly is arranged to provide a light beam. The light beam scanner includes a reflector arranged to reflect the light beam from the optical assembly to provide a reflected light beam to an object, a first drive mechanism operable to move the reflector relative to the optical assembly to move the reflected light beam relative to the object, and a second drive mechanism operable to move the reflector relative to the optical assembly to move the reflected light beam relative to the object. The transducer unit is arranged to detect photoacoustic signals emitted by the object in response to receiving the reflected light beam.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 8, 2024
    Inventors: Lidai Wang, Jiangbo Chen
  • Patent number: 11826955
    Abstract: A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: November 28, 2023
    Assignee: City University of Hong Kong
    Inventors: Dong Sun, Tanyong Wei, Lidai Wang, Dongfang Li, Yachao Zhang, Shuxun Chen
  • Patent number: 11766179
    Abstract: A method and a method for determining flow speed based on photoacoustic imaging or sensing. The method includes receiving multiple photoacoustic signals from a sample in response to transmission of multiple laser pulses of different wavelengths to the sample, and processing the photoacoustic signals based on a flow model that relates photoacoustic signals with flow speed to determine a flow speed of a liquid flow in the sample.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: September 26, 2023
    Assignee: City University of Hong Kong
    Inventors: Lidai Wang, Chao Liu
  • Publication number: 20230119416
    Abstract: A method of adjusting for the accuracy of a photoacoustic microscope image of blood oxygen saturation, comprising the use of two wavelengths to monitor the blood oxygen saturation level, and a further reference wavelength to provide an indication of wavelength-dependent fluence loss, and adjusting the blood oxygen saturation by linearization from the fluence loss.
    Type: Application
    Filed: October 18, 2021
    Publication date: April 20, 2023
    Inventors: Lidai WANG, Jingyi ZHU
  • Patent number: 11278207
    Abstract: A system for providing multi-wavelength laser includes an optical splitter arranged to split light received from a pulsed laser source into at least a first light beam and a second light beam; a first optical regulator arranged to adjust a wavelength of the first light beam and to output the adjusted first light beam; a second optical regulator arranged to introduce a time delay to the second light beam and to output the delayed second light beam; and an optical combiner arranged to combine the adjusted first light beam and the delayed second light beam, and to output a combined light beam.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 22, 2022
    Assignee: City University of Hong Kong
    Inventors: Lidai Wang, Yizhi Liang
  • Publication number: 20220024121
    Abstract: A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.
    Type: Application
    Filed: December 21, 2020
    Publication date: January 27, 2022
    Inventors: DONG SUN, TANYONG WEI, LIDAI WANG, DONGFANG LI, YACHAO ZHANG, SHUXUN CHEN
  • Publication number: 20220007944
    Abstract: A method and a method for determining flow speed based on photoacoustic imaging or sensing. The method includes receiving multiple photoacoustic signals from a sample in response to transmission of multiple laser pulses of different wavelengths to the sample, and processing the photoacoustic signals based on a flow model that relates photoacoustic signals with flow speed to determine a flow speed of a liquid flow in the sample.
    Type: Application
    Filed: July 13, 2020
    Publication date: January 13, 2022
    Inventors: Lidai Wang, Chao Liu
  • Patent number: 11137375
    Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 5, 2021
    Assignee: California Institute of Technology
    Inventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
  • Patent number: 10433733
    Abstract: A method for obtaining a 3-D OR-PAM image of microvasculature within a region of interest of a subject is provided. The method includes: focusing a first light pulse at a first depth beneath a first surface position within the region of interest; receiving a first PA signal in response to the first light pulse; focusing a second light pulse at a second depth beneath the first surface position within the region of interest; receiving a second PA signal in response to the second light pulse; and forming the 3-D OR-PAM image by combining the first PA signal and the second PA signal.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 8, 2019
    Assignee: Washington University
    Inventors: Lihong Wang, Lidai Wang, Konstantin Maslov
  • Publication number: 20180303349
    Abstract: A system for providing multi-wavelength laser includes an optical splitter arranged to split light received from a pulsed laser source into at least a first light beam and a second light beam; a first optical regulator arranged to adjust a wavelength of the first light beam and to output the adjusted first light beam; a second optical regulator arranged to introduce a time delay to the second light beam and to output the delayed second light beam; and an optical combiner arranged to combine the first adjusted light beam and the second delayed light beam, and to output a combined light beam.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 25, 2018
    Inventors: Lidai Wang, Yizhi Liang
  • Publication number: 20160305914
    Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 20, 2016
    Inventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
  • Publication number: 20160249812
    Abstract: A method for obtaining a 3-D OR-PAM image of microvasculature within a region of interest of a subject is provided. The method includes: focusing a first light pulse at a first depth beneath a first surface position within the region of interest; receiving a first PA signal in response to the first light pulse; focusing a second light pulse at a second depth beneath the first surface position within the region of interest; receiving a second PA signal in response to the second light pulse; and forming the 3-D OR-PAM image by combining the first PA signal and the second PA signal.
    Type: Application
    Filed: May 6, 2016
    Publication date: September 1, 2016
    Inventors: Lihong Wang, Lidai Wang, Konstantin Maslov
  • Publication number: 20140142404
    Abstract: A single-RBC photoacoustic flowoxigraphy (FOG) device is described that delivers laser pulses of two different wavelengths separated by a pulse separation period of about 20 ?s. This separation period is sufficiently brief to enable pulses of two different wavelengths to illuminate the same single moving RBC. The acoustic signals elicited by the single RBC in response to the laser pulses of two different wavelengths may be analyzed using pulse oximetry methods similar to those described herein above to simultaneously determine a variety of functional parameters.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicant: The Washington University
    Inventors: Lihong V. Wang, Konstantin Maslov, Lidai Wang