Patents by Inventor Lidija Covic

Lidija Covic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pepducin design and use
    Patent number: 10913781
    Abstract: Disclosed here is the rational design and use of potent and specific GPCR antagonist pepducins based on GPCR regions such as the third intracellular loop and adjacent regions.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: February 9, 2021
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • CXCR4 receptor compounds
    Patent number: 9096646
    Abstract: The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: August 4, 2015
    Assignee: Anchor Therapeutics, Inc.
    Inventors: Thomas J. McMurry, Athan Kuliopulos, Lidija Covic, Boris Tchernychev
  • G PROTEIN COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF ACTIVATING AND INHIBITING G PROTEIN COUPLED RECEPTORS USING THE SAME
    Publication number: 20140227718
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: January 30, 2013
    Publication date: August 14, 2014
    Applicant: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • PEPDUCIN DESIGN AND USE
    Publication number: 20140087993
    Abstract: Disclosed here is the rational design and use of potent and specific GPCR antagonist pepducins based on GPCR regions such as the third intracellular loop and adjacent regions.
    Type: Application
    Filed: April 9, 2012
    Publication date: March 27, 2014
    Applicant: TUFTS MEDICAL CENTER, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • Methods of activating or inhibiting G protein coupled receptors (GPCRs)
    Patent number: 8563519
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: October 22, 2013
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • CXCR4 Receptor Compounds
    Publication number: 20130210709
    Abstract: The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CX-CR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow trans-plantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.
    Type: Application
    Filed: November 4, 2009
    Publication date: August 15, 2013
    Inventors: Thomas J. McMurry, Athan Kuliopulos, Lidija Covic, Boris Tchernychev
  • G protein coupled receptor agonists and antagonists and methods of use
    Patent number: 8440627
    Abstract: The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with GPCRs, such as in treating conditions in which chemokine receptors play a role, e.g., sepsis, arthritis, inflammation and autoimmune diseases.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 14, 2013
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic, Nicole Kaneider
  • G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Patent number: 8389480
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: March 5, 2013
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Patent number: 8354378
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: January 15, 2013
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Patent number: 8324172
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: December 4, 2012
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • CXCR5 RECEPTOR COMPOUNDS
    Publication number: 20110300167
    Abstract: The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor CXCR5. The CXCR5 receptor compounds are derived from the intracellular loops and domains of the CXCR5 receptor. The invention also relates to the use of these CXCR5 receptor compounds and pharmaceutical compositions comprising the CXCR5 receptor compounds in the treatment of diseases and conditions associated with CXCR5 receptor modulation such as autoimmune diseases including lupus, HIV and rheumatoid arthritis, Primary Sjogren's Syndrome, chronic lymphocytic leukemia, Burkitt Lymphoma, colon and breast cancer tumor metastasis, Multiple Sclerosis and compromised immune function.
    Type: Application
    Filed: November 4, 2009
    Publication date: December 8, 2011
    Inventors: Thomas J. McMurry, Athan Kuliopulos, Lidija Covic
  • G PROTEIN COUPLED RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF ACTIVATING AND INHIBITING G PROTEIN COUPLED RECEPTORS USING THE SAME
    Publication number: 20100137207
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: September 11, 2009
    Publication date: June 3, 2010
    Applicant: Tufts Medical Center
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Patent number: 7696168
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: April 13, 2010
    Assignee: Tufts Medical Center, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • G PROTEIN COUPLED RECEPTOR ANTAGONISTS AND METHODS OF ACTIVATING AND INHIBITING G PROTEIN COUPLED RECEPTORS USING THE SAME
    Publication number: 20090270322
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: February 27, 2009
    Publication date: October 29, 2009
    Inventors: Athan Kuliopulos, Lidija Covic
  • G Protein Coupled Receptor Agonists and Antagonists and Methods of Use
    Publication number: 20080214451
    Abstract: The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with GPCRs, such as in treating conditions in which chemokine receptors play a role, e.g., sepsis, arthritis, inflammation and autoimmune diseases.
    Type: Application
    Filed: November 4, 2005
    Publication date: September 4, 2008
    Inventors: Athan Kuliopulos, Lidija Covic, Nicole Kaneider
  • G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Publication number: 20070179090
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: November 28, 2006
    Publication date: August 2, 2007
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
    Publication number: 20060166274
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: March 7, 2005
    Publication date: July 27, 2006
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
    Patent number: 6864229
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 8, 2005
    Assignee: New England Medical Center Hospitals, Inc.
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
    Publication number: 20030148449
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: September 20, 2002
    Publication date: August 7, 2003
    Inventors: Athan Kuliopulos, Lidija Covic
  • G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
    Publication number: 20020076755
    Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
    Type: Application
    Filed: April 23, 2001
    Publication date: June 20, 2002
    Inventors: Athan Kuliopulos, Lidija Covic