Abstract: In one aspect, the present invention is directed to a toothbrush comprising: a toothpaste dispenser wherein the toothpaste container thereof is deployed within the toothbrush; a passageway from the container to the bristles of the toothbrush, wherein the container and the passageway generate a closed space; and a closure at the end of the passageway, for preventing contact between the air and the toothpaste stored within the closed space. According to one embodiment of the invention, the dispenser dispenses toothpaste upon applying pressure to the container. The toothbrush may further comprise a no-return mechanism, for preventing toothpaste within the closed space from falling back. The no-return mechanism may comprise a valve that comprises, e.g., a flexible lid attached to the body of the toothbrush, for closing the passageway of the valve.