Patents by Inventor Lie-Fen Shyur

Lie-Fen Shyur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8048860
    Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: November 1, 2011
    Assignee: Academia Sinica
    Inventors: Wen-Chin Yang, Shu-Lin Chang, Lee-Tian Chang, Yi-Ming Chiang, Lie-Fen Shyur
  • Patent number: 8048455
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: November 1, 2011
    Assignee: Academia Sinica
    Inventors: Lie-fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Publication number: 20100317603
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 16, 2010
    Applicant: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Patent number: 7691575
    Abstract: Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN ? or IL-2 transcription.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: April 6, 2010
    Assignee: Academia Sinica
    Inventors: Wen-Chin Yang, Shu-Lin Chang, Yi-Ming Chiang, Lie-Fen Shyur
  • Patent number: 7547455
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: June 16, 2009
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Patent number: 7527958
    Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: May 5, 2009
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang
  • Publication number: 20090062216
    Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: November 3, 2008
    Publication date: March 5, 2009
    Applicant: Academia Sinica
    Inventors: Wen-Chin Yang, Shu-Lin Chang, Lee-Tian Chang, Yi-Ming Chiang, Lie-Fen Shyur
  • Patent number: 7419690
    Abstract: A method for enhancing proliferation of bone marrow cells or spleen cells with an alcohol-insoluble extract of a Dioscorea plant tuber obtained by stepwise treatment of an aqueous extract of Dioscorea plant tuber with aqueous-alcohol solvents.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 2, 2008
    Assignee: Academia Sinica
    Inventors: Ning-Sun Yang, Pei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Publication number: 20080152737
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Application
    Filed: September 20, 2007
    Publication date: June 26, 2008
    Applicant: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Publication number: 20070053998
    Abstract: A compound of the formula: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4. Also disclosed is use of the compound to inhibit Th1 differentiation, promote Th2 differentiation, and treat certain disorders.
    Type: Application
    Filed: September 2, 2005
    Publication date: March 8, 2007
    Inventors: Wen-Chin Yang, Shu-Lin Chang, Lee-Tian Chang, Yi-Ming Chiang, Lie-Fen Shyur
  • Publication number: 20070048394
    Abstract: Methods useful, for example, in identifying plant compositions that have immunomodulatory activity. Also disclosed is an Asteraceae plant immunomodulatory composition useful for increasing an immune response, e.g., IFN ? or IL-2 transcription.
    Type: Application
    Filed: August 29, 2005
    Publication date: March 1, 2007
    Inventors: Wen-Chin Yang, Shu-Lin Chang, Yi-Ming Chiang, Lie-Fen Shyur
  • Publication number: 20060105070
    Abstract: An extract from a tuber of a Dioscorea plant. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant and a cytokine, as well as methods of enhancing proliferation of bone marrow or spleen cells and stimulating regeneration of a specific lineage of hematopoietic cells.
    Type: Application
    Filed: January 12, 2006
    Publication date: May 18, 2006
    Inventors: Ning-Sun Yang, Fei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Patent number: 7037696
    Abstract: A truncated glucanase with an improved thermal stability and a higher specific enzymatic activity than the wild-type enzyme. The truncated glucanase is obtained by removing a number of amino acid residues from the C-terminal of the wild-type 1,3-1,4-?-D-glucanase of Fibrobacter succinogenes. The removal of the C-terminal amino acid residues can be conducted at the genetic level by modifying the gene encoding for the wild type enzyme using, for example, a PCR-based method. Or, it can also be conducted at the protein level by first producing the wild-type enzyme protein and then subjecting the wild-type protein to certain protease action to remove a portion of its C-terminal.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: May 2, 2006
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Jui-Lin Chen, Ning-Sun Yang
  • Patent number: 7033617
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of the Anoectochilus family. These active extracts and fractions are useful for preventing or inhibiting tumor growth.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: April 25, 2006
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Ning-Sun Yang, Pei-Ling Kang, Show-Jane Sun, Sheng-Yang Wang
  • Publication number: 20050118292
    Abstract: An extract from a tuber of a Dioscorea plant. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant and a cytokine, as well as methods of enhancing proliferation of bone marrow or spleen cells and stimulating regeneration of a specific lineage of hematopoietic cells.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 2, 2005
    Inventors: Ning-Sun Yang, Pei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Publication number: 20050009164
    Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
    Type: Application
    Filed: February 6, 2004
    Publication date: January 13, 2005
    Inventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang
  • Publication number: 20040009239
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of the Anoectochilus family. These active extracts and fractions are useful for preventing or inhibiting tumor growth.
    Type: Application
    Filed: July 12, 2002
    Publication date: January 15, 2004
    Applicant: Academia Sinica
    Inventors: Lie-Fen Shyur, Ning-Sun Yang, Pei-Ling Kang, Show-Jane Sun, Sheng-Yang Wang