Patents by Inventor Lie-Rong Chen

Lie-Rong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of fluconazole and pharmaceutically acceptable salts thereof
    Patent number: 5710280
    Abstract: A process for preparing fluconazole, including the steps of (1) acylating 1,3-difluorobenzene (DFB) to obtain 2-chloro-2',4'-difluoroacetophenone (CAP); (2) alkylating 4-amino-4H-1,2,4-triazole (4-AT) with CAP to obtain 2-(1H-1,2,4-triazol-1-yl)-2',4'-difluoroacetophenone (TAAP) salt; (3) deaminating TAAP salt to obtain TAAP; and (4) reacting TAAP with 1,2,4-triazole to obtain fluconazole.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: January 20, 1998
    Assignee: Development Center for Biotechnology
    Inventors: Kae-Shyang Shih, Lie-Rong Chen, Ching-Wei Liu, Chia-Lin J. Wang