Patents by Inventor Lief Fenno

Lief Fenno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized step function opsin proteins and methods of using the same
    Patent number: 10568307
    Abstract: Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: February 25, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno
  • LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
    Publication number: 20190241627
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Application
    Filed: December 5, 2018
    Publication date: August 8, 2019
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • Light-activated chimeric opsins and methods of using the same
    Patent number: 10196431
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: February 5, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • OPTICALLY-CONTROLLED CNS DYSFUNCTION
    Publication number: 20180333456
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Application
    Filed: April 19, 2018
    Publication date: November 22, 2018
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • Optically-controlled CNS dysfunction
    Patent number: 9968652
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 15, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
    Publication number: 20180051058
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Application
    Filed: November 3, 2017
    Publication date: February 22, 2018
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • Light-activated chimeric opsins and methods of using the same
    Patent number: 9850290
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: December 26, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • STABILIZED STEP FUNCTION OPSIN PROTEINS AND METHODS OF USING THE SAME
    Publication number: 20160316730
    Abstract: Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
    Type: Application
    Filed: July 19, 2016
    Publication date: November 3, 2016
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno
  • OPTICALLY-CONTROLLED CNS DYSFUNCTION
    Publication number: 20160303192
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Application
    Filed: June 27, 2016
    Publication date: October 20, 2016
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • Optically controlled CNS dysfunction
    Patent number: 9421258
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: August 23, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
    Publication number: 20160237126
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 18, 2016
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • Light-activated chimeric opsins and methods of using the same
    Patent number: 9340589
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: May 17, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • LIGHT-ACTIVATED CHIMERIC OPSINS AND METHODS OF USING THE SAME
    Publication number: 20160002302
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 7, 2016
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • Light-activated chimeric opsins and methods of using the same
    Patent number: 9175095
    Abstract: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: November 3, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno, Peter Hegemann, Matthias Prigge
  • Optically-Controlled CNS Dysfunction
    Publication number: 20150174244
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 25, 2015
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • Optically controlled CNS dysfunction
    Patent number: 8932562
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: January 13, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno
  • Stabilized Step Function Opsin Proteins and Methods of Using the Same
    Publication number: 20130347137
    Abstract: Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
    Type: Application
    Filed: November 4, 2011
    Publication date: December 26, 2013
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lief Fenno
  • Optically-Controlled CNS Dysfunction
    Publication number: 20130295015
    Abstract: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
    Type: Application
    Filed: November 4, 2011
    Publication date: November 7, 2013
    Applicant: The Board of Trustees of Leland Stanford Jnior Universtiy
    Inventors: Karl Deisseroth, Kay Tye, Lief Fenno