Patents by Inventor Liefeng HU

Liefeng HU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetravalent platinum compound-bicyclic double-bond-containing amphiphilic polymer prodrug, nano-micelle, preparation method and application thereof
    Patent number: 10947261
    Abstract: A tetravalent platinum compound-bicyclic double-bond-containing amphiphilic polymer prodrug, which has the structure as shown in formula (I): when m=1, represents when m=0, represents R represents —CH3 or —CH2CH3; L1 and L2 independently represent Cl, N3, NO3, and n is from 10 to 80. A preparation method of the prodrug is also disclosed. The method includes a step of reacting an axially dihydroxy-coordinated tetravalent platinum compound with a bicyclic double-bond-containing orthoester precursor. In addition, a nano-micelle formed by the prodrug and an application thereof are further disclosed. The amphiphilic polymer prodrug and the micelle formed therefrom have pH hypersensitivity and reduction dual responsiveness.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 16, 2021
    Assignee: ANHUI UNIVERSITY
    Inventors: Rupei Tang, Liefeng Hu
  • Tetravalent Platinum Compound-Bicyclic Double-bond-containing Amphiphilic Polymer Prodrug, Nano-micelle, Preparation Method and Application Thereof
    Publication number: 20190345181
    Abstract: A tetravalent platinum compound-bicyclic double-bond-containing amphiphilic polymer prodrug, which has the structure as shown in formula (I): when m=1, represents when m=0, represents R represents —CH3 or —CH2CH3; L1 and L2 independently represent Cl, N3, NO3, and n is from 10 to 80. A preparation method of the prodrug is also disclosed. The method includes a step of reacting an axially dihydroxy-coordinated tetravalent platinum compound with a bicyclic double-bond-containing orthoester precursor. In addition, a nano-micelle formed by the prodrug and an application thereof are further disclosed. The amphiphilic polymer prodrug and the micelle formed therefrom have pH hypersensitivity and reduction dual responsiveness.
    Type: Application
    Filed: December 29, 2017
    Publication date: November 14, 2019
    Applicant: ANHUI UNIVERSITY
    Inventors: Rupei TANG, Liefeng HU