Patents by Inventor Lieh Yoon Low

Lieh Yoon Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC ANTIBODIES WITH CLEAVABLE C-TERMINAL CHARGE-PAIRED TAGS
    Publication number: 20220089756
    Abstract: The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.
    Type: Application
    Filed: May 8, 2019
    Publication date: March 24, 2022
    Inventors: John K. KAWOOYA, Alex W. JACOBITZ, Christopher MOHR, Stephen SMITH, Kevin GRAHAM, Ray Lieh Yoon LOW, Oliver THIEL, Dante ROMANINI, Victoria WAGNER, Neeraj J. AGRAWAL
  • MANNOSE-6-PHOSPHATE BEARING PEPTIDES FUSED TO LYSOSOMAL ENZYMES
    Publication number: 20200376095
    Abstract: A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.
    Type: Application
    Filed: June 18, 2020
    Publication date: December 3, 2020
    Inventors: Michael F. CONCINO, Bettina STRACK-LOGUE, Muthuraman MEIYAPPAN, Angela W. NORTON, Bohong ZHANG, Andrea ISKENDERIAN, Lieh Yoon LOW, Dianna LUNDBERG, Alla ROMASHKO, Hicham NAIMY
  • Mannose-6-phosphate bearing peptides fused to lysosomal enzymes
    Patent number: 10722559
    Abstract: A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: July 28, 2020
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Michael F. Concino, Bettina Strack-Logue, Muthuraman Meiyappan, Angela W. Norton, Bohong Zhang, Andrea Iskenderian, Lieh Yoon Low, Dianna Lundberg, Alla Romashko, Hicham Naimy
  • MANNOSE-6-PHOSPHATE BEARING PEPTIDES FUSED TO LYSOSOMAL ENZYMES
    Publication number: 20170232076
    Abstract: A targeted therapeutic including a lysosomal enzyme and a lysosomal targeting moiety that is a peptide containing at least one N-linked glycosylation site. Methods of producing the targeted therapeutic may include nucleotide acids encoding the same and host cells co-expressing GNPT. Pharmaceutical compositions comprising the targeted therapeutic and methods of using the same to treat a lysosomal storage disease.
    Type: Application
    Filed: August 11, 2015
    Publication date: August 17, 2017
    Inventors: Michael F. CONCINO, Bettina STRACK-LOGUE, Muthuraman MEIYAPPAN, Angela W. NORTON, Bohong ZHANG, Andrea ISKENDERIAN, Lieh Yoon LOW, Dianna LUNDBERG, Alla ROMASHKO, Hicham NAIMY
  • LIPOPROTEIN LIPASE FOR TREATMENT OF HYPERTRIGLYCERIDEMIC-RELATED CONDITIONS INCLUDING ACUTE PANCREATITIS
    Publication number: 20170202929
    Abstract: A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 20, 2017
    Inventors: Omar L. Francone, Lin Guey, Kevin Holmes, Bruce Tangarone, Matthew Traylor, Lenore von Krusenstiern, Tracy Dowie, Lieh Yoon Low, Bohong Zhang, Muthuraman Meiyappan, Angela Norton, Bettina Strack-Logue, Dianna Lundberg, Michael F. Concino
  • Lipoprotein lipase for treatment of hypertriglyceridemic-related conditions including acute pancreatitis
    Patent number: 9597376
    Abstract: A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 21, 2017
    Assignee: Shire Human Genetic Therapies, Inc.
    Inventors: Omar L. Francone, Lin Guey, Kevin Holmes, Bruce Tangarone, Matthew Traylor, Lenore von Krusenstiern, Tracy Dowie, Lieh Yoon Low, Bohong Zhang, Muthuraman Meiyappan, Angela Norton, Bettina Strack-Logue, Dianna Lundberg, Michael F. Concino
  • LIPOPROTEIN LIPASE FOR TREATMENT OF HYPERTRIGLYCERIDEMIC-RELATED CONDITIONS INCLUDING ACUTE PANCREATITIS
    Publication number: 20160051637
    Abstract: A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in particular, acute pancreatitis secondary to or exacerbated by hypertriglyceridemia, and hypertriglyceridemia and its associated diseases in general, including cardiovascular and metabolic diseases, endocrine disorders, and fat embolism syndrome.
    Type: Application
    Filed: August 19, 2015
    Publication date: February 25, 2016
    Inventors: Omar L. Francone, Lin Guey, Kevin Holmes, Bruce Tangarone, Matthew Traylor, Lenore von Krusenstiern, Tracy Dowie, Lieh Yoon Low, Bohong Zhang, Muthuraman Meiyappan, Angela Norton, Bettina Strack-Logue, Dianna Lundberg, Michael F. Concino