Patents by Inventor Lieneke Pool

Lieneke Pool has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tolerogenic antigen presenting cells
    Patent number: 12582706
    Abstract: There is provided inter alia according to the invention an ex vivo method of obtaining tolerogenic antigen presenting cells (APCs) that have the capability to induce tolerance in the immune system to an antigen, the method comprising (a) isolating monocytes from a sample obtained from a mammal; and (b) culturing the isolated monocytes in a cell culture to induce differentiation of the monocytes into antigen presenting cells having a tolerogenic phenotype, wherein the cell culture comprises (i) retinoic acid and TGFbeta, (ii) retinoic acid, TGFbeta and an AhR agonist or (iii) retinoic acid and an AhR agonist.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: March 24, 2026
    Assignee: Cell4Cure AB
    Inventors: Lieneke Pool, Pavlos Englezou, Maria Wigren, Hanne Romedahl
  • NOVEL METHOD
    Publication number: 20230118721
    Abstract: There is provided inter alia according to the invention an ex vivo method of obtaining tolerogenic antigen presenting cells (APCs) that have the capability to induce tolerance in the immune system to an antigen, the method comprising (a) isolating monocytes from a sample obtained from a mammal; and (b) culturing the isolated monocytes in a cell culture to induce differentiation of the monocytes into antigen presenting cells having a tolerogenic phenotype, wherein the cell culture comprises (i) retinoic acid and TGFbeta, (ii) retinoic acid, TGFbeta and an AhR agonist or (iii) retinoic acid and an AhR agonist.
    Type: Application
    Filed: December 11, 2020
    Publication date: April 20, 2023
    Inventors: Lieneke Pool, Pavlos Englezou, Maria Wigren, Hanne Romedahl