Patents by Inventor Liesbeth Brown
Liesbeth Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10342662Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: GrantFiled: September 29, 2017Date of Patent: July 9, 2019Assignee: DePuy Synthes Products, Inc.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Cormier
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Publication number: 20180085220Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: ApplicationFiled: September 29, 2017Publication date: March 29, 2018Applicant: DePuy Synthes Products, Inc.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Cormier
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Patent number: 9801725Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: GrantFiled: July 25, 2016Date of Patent: October 31, 2017Assignee: DePuy Synthes Products, Inc.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Cormier
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Publication number: 20170049572Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: ApplicationFiled: July 25, 2016Publication date: February 23, 2017Applicant: DePuy Synthes Products, Inc.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Cormier
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Publication number: 20160081804Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: ApplicationFiled: October 7, 2015Publication date: March 24, 2016Applicant: DEPUY SYNTHES PRODUCTS, INC.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley
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Patent number: 9168138Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: GrantFiled: December 9, 2009Date of Patent: October 27, 2015Assignee: DePuy Synthes Products, Inc.Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Webster
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Patent number: 9125888Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: December 19, 2012Date of Patent: September 8, 2015Assignee: DEPUY MITEK, LLCInventors: Brooks J. Story, M. E. Liesbeth Brown, Francois Binette
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Publication number: 20140081209Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: ApplicationFiled: November 21, 2013Publication date: March 20, 2014Applicant: DePuy Mitek, LLCInventors: Brooks J. Story, Francois Binette, M.E. Liesbeth Brown
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Patent number: 8592201Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: GrantFiled: August 6, 2012Date of Patent: November 26, 2013Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Patent number: 8354100Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: March 23, 2011Date of Patent: January 15, 2013Assignee: DePuy Mitek, Inc.Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Publication number: 20120302958Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: ApplicationFiled: August 6, 2012Publication date: November 29, 2012Applicant: JOHNSON & JOHNSON REGENERATIVE THERAPEUTICS, LLCInventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Patent number: 8257963Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: GrantFiled: May 20, 2008Date of Patent: September 4, 2012Assignee: DePuy Mitek, Inc.Inventors: Francois Binette, Brooks J. Story, M. E. Liesbeth Brown
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Publication number: 20110137418Abstract: Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.Type: ApplicationFiled: December 9, 2009Publication date: June 9, 2011Inventors: Michael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Webster
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Patent number: 7927599Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.Type: GrantFiled: December 4, 2008Date of Patent: April 19, 2011Assignee: Ethicon, Inc.Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
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Publication number: 20080299173Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).Type: ApplicationFiled: May 20, 2008Publication date: December 4, 2008Applicant: JOHNSON & JOHNSON REGENERATIVE THERAPEUTICS, LLCInventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown