Patents by Inventor Lieven J. Stuyver

Lieven J. Stuyver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds with the bicyclo[4.2.1]nonane system for the treatment of infections
    Patent number: 8093380
    Abstract: The disclosed invention is a bicyclo[4.2.1]nonane and its pharmaceutically acceptable salt or prodrug, and its composition and method of use to treat Flaviviridae (Hepacivirus, Flavivirus, and Pestivirus) infections in a host, including animals, and especially humans.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: January 10, 2012
    Assignee: Pharmasset, Inc.
    Inventors: Peiyuan Wang, Lieven J. Stuyver, Kyoichi A. Watanabe, Abdalla Hassan, Byoung-Kwon Chun, Laurent Hollecker
  • Modified nucleosides as antiviral agents
    Publication number: 20040157793
    Abstract: The present invention relates to 3′ substituted-2′, 3′-didehydro-2′, 3′-dideoxy-&bgr;-L-nucleosides and their pharmaceutically acceptable salts and prodrugs thereof, for the treatment of infectious viral diseases, in general, particularly HBV and HIV viral infections and more particularly, HBV and HIV viral infections that are resistant to other antiviral drugs.
    Type: Application
    Filed: November 12, 2003
    Publication date: August 12, 2004
    Inventors: Lieven J. Stuyver, Chung K. Chu
  • Compounds with the bicyclo[4.2.1]nonane system for the treatment of flavivridae infections
    Publication number: 20040082574
    Abstract: The disclosed invention is a bicyclo[4.2.1]nonane and its pharmaceutically acceptable salt or prodrug, and its composition and method of use to treat Flaviviridae (Hepacivirus, Flavivirus, and Pestivirus) infections in a host, including animals, and especially humans.
    Type: Application
    Filed: August 1, 2003
    Publication date: April 29, 2004
    Inventors: Peiyuan Wang, Lieven J. Stuyver, Kyoichi A. Watanabe, Abdalla Hassan, Byoung-Kwon Chun, Laurent Hollecker
  • Modified fluorinated nucleoside analogues
    Publication number: 20040002476
    Abstract: The invention is a compound, composition, use for and a method of treating Flaviviridae (Hepacivirus, Flavirius, Pestivirus) infections, including BVDV and HCV, or abnormal cellular proliferation, including malignant tumors, in a host including animals, and especially humans, using a &bgr;-D or &bgr;-L nucleoside of general formula (I)-(XX), or their pharmaceutically acceptable salt or prodrug thereof.
    Type: Application
    Filed: February 13, 2003
    Publication date: January 1, 2004
    Inventors: Lieven J. Stuyver, Junxing Shi, Kyoichi A. Watanabe
  • Dosing regimen for gemcitabine HCV therapy
    Publication number: 20030225029
    Abstract: A dosage regiment for the treatment of a Flaviviridae infection, including a hepatitis C viral infection, that includes administering gemcitabine (or its salt, prodrug or derivative, as described herein) in a dosage range of approximately 50 mg/m2 to about 1300 mg/m2 per day for between one and seven days (e.g. 1, 2, 3, 4, 5, 6, or 7 days) followed by cessation of therapy. Viral load is optionally monitored over time, and after cessation, viral rebound is monitored. Therapy is not resumed unless a significant viral load is again observed, and then therapy for 1-7 days and more preferred, 1, 2 or 3 days, is repeated. This therapy can be continued indefinitely to monitor and maintain the health of the patient.
    Type: Application
    Filed: February 14, 2003
    Publication date: December 4, 2003
    Inventor: Lieven J. Stuyver