Patents by Inventor Lifang Shi

Lifang Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200029596
    Abstract: The present invention discloses a fat-soluble nutrient microcapsule and a preparation method thereof. The fat-soluble nutrient microcapsule comprises the following components in percentage by weight: a fat-soluble nutrient (0.2-51.6%), an antioxidant (0.2-5.0%), a wall material (41.4-97.6%) and a moisture (2.0-5.0%) and the ratio of the fat-soluble nutrient that keeps active in the fat-soluble nutrient microcapsule to the fat-soluble nutrient that is initially added is 0.990-0.997:1. The preparation method of the fat-soluble nutrient microcapsule comprises an emulsification process and a granulation process, wherein the emulsification is performed in a cavitation emulsifier. By the preparation method, the nutrient active substance of the fat-soluble nutrient microcapsule has less lost and high stability.
    Type: Application
    Filed: April 26, 2018
    Publication date: January 30, 2020
    Inventors: JIANDONG LI, BAISHAN HU, ZHIRONG CHEN, LIFANG SHI, QICHUAN LI, XIAOYONG ZHU, GUISHENG QIU, QILEI ZHANG, YOUMIN YANG, LINPU CAI
  • Publication number: 20190299523
    Abstract: A multi-degree-of-freedom (Multi-DOF) 3D printing device includes a printer mechanism, a rotatable platform, a visual inspection system, and a control system. The printing mechanism includes a print head. The printing mechanism and the rotatable platform are combined to have three degrees of freedom of translation, and the rotatable platform has two degrees of freedom of rotation. The visual inspection system includes a camera mounted to nearby the print head and the relative position of camera and print head remains constant. The control system is configured to implement the printing process. The model is decomposed into several components, each of which could be printed in a single direction. After one component is printed out, the platform is then rotated so that the cutting plane for the component will be printed is horizontal.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 3, 2019
    Applicants: Beijing University of Technology, Beijing Cloud Profound Technologies Company Limited
    Inventors: Lifang Wu, Miao Yu, Yisong Gao, Lidong Zhao, Yuan Gao, Xiaohua Guo, Meng Jian, Changling Wang, Ziming Zhang, Yuanzheng Shi
  • Patent number: 10212957
    Abstract: Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitro—gen atmosphere and at 10-30° C. to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1 ?m, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: February 26, 2019
    Assignees: ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD.
    Inventors: Dan Qiu, Lifang Shi, Jiandong Li, Zhirong Chen, Jiachao Zhou
  • Publication number: 20180184689
    Abstract: The present invention discloses a method for preparing controlled release type lutein feed additive. Steps: lutein extract, glycerol and fat are mixed and dissolved, then alkali liquor is dropped under condition of mechanical stirring and sheering emulsification to allow the lutein to be fully saponified. Then fat is added and alkaline saponification is conducted, adjusting the viscosity and neutralizing and conducting spray granulation to the mixed liquor to obtain controlled release lutein feed additive. By utilizing the combined effects of glycerol and fat, the present invention realizes saponification and microcapsule formation using simple method.
    Type: Application
    Filed: June 21, 2016
    Publication date: July 5, 2018
    Inventors: DAN QIU, ZHIRONG CHEN, LIFANG SHI, JIANDONG LI, LINPU CAI, YUFENG LIANG, MINCONG CAI, LIFENG ZHAO
  • Publication number: 20160374375
    Abstract: Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitro—gen atmosphere and at 10-30° C. to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1 ?m, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.
    Type: Application
    Filed: June 3, 2014
    Publication date: December 29, 2016
    Inventors: DAN QIU, LIFANG SHI, JIANDONG LI, ZHIRONG CHEN, JIACHAO ZHOU
  • Patent number: 9173818
    Abstract: A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: November 3, 2015
    Assignee: ZHEJIANG NHU COMPANY LTD
    Inventors: Hong Yin, Jianfeng Chen, Zhirong Chen, Jiexin Wang, Yong Qi, Hong Zhao, Lifang Shi, Dan Qiu
  • Publication number: 20140001662
    Abstract: A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules.
    Type: Application
    Filed: March 25, 2011
    Publication date: January 2, 2014
    Applicant: ZHEJIANG NHU COMPANY LTD
    Inventors: Hong Yin, Jianfeng Chen, Zhirong Chen, Jiexin Wang, Yong Qi, Hong Zhao, Lifang Shi, Dan Qiu
  • Patent number: 8540908
    Abstract: A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 ?m, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: September 24, 2013
    Assignees: Zhejiang NHU Company Ltd., Zhejiang University, Beijing University of Chemical Technology
    Inventors: Zhirong Chen, Jianfeng Chen, Hong Yin, Hong Zhao, Dan Qiu, Lifang Shi, Jiandong Li, Guangwen Chu, Lei Shao
  • Publication number: 20120018912
    Abstract: A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 ?m, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules.
    Type: Application
    Filed: March 18, 2010
    Publication date: January 26, 2012
    Applicants: ZHEJIANG UNIVERSITY, ZHEJIANG NHU COMPANY LTD
    Inventors: Zhirong Chen, Jianfeng Chen, Hong Yin, Hong Zhao, Dan Qiu, Lifang Shi, Jiandong Li, Guangwen Chu, Lei Shao
  • Publication number: 20050005324
    Abstract: There are disclosed novel pin1 gene promoter isoforms and amt gene promoter isoforms. The promoters and their functional elements may be used independently or in combination with one or more enhancer elements to increase or otherwise manipulate gene expression. The promoters disclosed may be used in Controlled Environment Agriculture for heterologous protein production. Also disclosed are methods for using the promoter and promoter elements of the instant invention, as well as vectors and transgenic plants comprising the same.
    Type: Application
    Filed: July 30, 2004
    Publication date: January 6, 2005
    Inventors: Ziyu Dai, LiFang Shi, Brian Hooker
  • Patent number: 6783978
    Abstract: The promoter of the ribosomal protein gene L25 is operably linked to a structural gene. This chimeric gene is placed in an expression vector. The expression vector containing the chimeric gene is used to transform plants cells and plants. Seeds are obtained from the transformed plants. A product, such as a protein, encoded by the structural gene is isolated from the transformed plant cells and plants.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: August 31, 2004
    Assignee: Battelle Memorial Institute
    Inventors: Lifang Shi, Johnway Gao, Brian S. Hooker, Ziyu Dai
  • Publication number: 20040006797
    Abstract: Disclosed herein are inventions in the field of plant biochemistry and genetics. More specifically polynucleotides for use in crop improvement are provided, in particular, plant polynucleotides encoding transcription factors and the polypeptides encoded by such polynucleotides are disclosed. Arrays and DNA constructs comprising such polynucleotides, and polypeptides encoded by such polynucleotides and methods of using the novel polynucleotides and other plant polynucleotide homologs are also disclosed. Novel plants and seeds with improved biological characteristics can be obtained by use of said polynucleotides.
    Type: Application
    Filed: April 4, 2003
    Publication date: January 8, 2004
    Inventors: Lifang Shi, Stanton B. Dotson, Jingrui Wu, Linda L. Lutfiyya, Christine Shewmaker, Alison Van Eenennaam, Eric D. Aasen, Diane Ruezinsky
  • Publication number: 20030073828
    Abstract: This invention provides transgenic plants that have increased or decreased activity of uridine 5′-diphospho-galactose 4-epimerase. Controlling the level of uridine 5′-diphospho-galactose 4-epimerase in the transgenic plants is used to regulate the nutritional profile of the plant by controlling the use of glucose and/or galactose. An isolated polynucleotide coding for the potato uridine 5′-diphospho-galactose 4-epimerase protein, its antisense equivalent and the nucleic acid sequence of potato uridine 5′-diphospho-galactose 4-epimerase are also provided. The present invention also provides a method for reducing the activity of uridine 5′-diphospho-galactose 4-epimerase activity in plants. The present invention also provides a method of producing bulk quantities of uridine 5′-diphospho-galactose 4-epimerase enzyme in transgenic plants.
    Type: Application
    Filed: February 1, 2002
    Publication date: April 17, 2003
    Applicant: Battelle Memorial Institute
    Inventors: Ziyu Dai, LiFang Shi, Brian S. Hooker
  • Publication number: 20020170095
    Abstract: There are disclosed novel pin1 gene promoter isoforms and amt gene promoter isoforms. The promoters and their functional elements may be used independently or in combination with one or more enhancer elements to increase or otherwise manipulate gene expression. The promoters disclosed may be used in Controlled Environment Agriculture for heterologous protein production. Also disclosed are methods for using the promoter and promoter elements of the instant invention, as well as vectors and transgenic plants comprising the same.
    Type: Application
    Filed: January 22, 2002
    Publication date: November 14, 2002
    Applicant: Battelle Memorial Institute
    Inventors: Ziyu Dai, LiFang Shi, Brian S. Hooker
  • Patent number: 6355864
    Abstract: Synergistically functional, yet separable, cis-acting enhancer elements from the rpL34 promoter are disclosed. These enhancer elements of the instant invention may be used in combination with a plurality of promoters to increase gene expression without affecting the intrinsic specificity of the promoters. Also disclosed are methods for using the enhancer elements of the instant invention as well as vectors and transgenic plants comprising the enhancer elements.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: March 12, 2002
    Assignee: Battelle Memorial Institute
    Inventors: Lifang Shi, Ziyu Dai, Johnway Gao, Brian S. Hooker, Daniel B. Anderson