Abstract: Disclosed is a crystal form of an allyl-containing methylpyridopyrimidine compound, and specifically discloses a crystal form of a compound as shown in formula (I) and of a salt of the compound.

Abstract: A rapid DLP 3D printing control parameter optimization method combining continuous and layered molding includes the following steps: confirming the maximum printable distance of each slice by analyzing the printable area of the model slice. The liquid-liquid interface printing scene was further established, and the flow behavior of the resin between the printed object and the fluorinated oil after printing a layer of slices was simulated and recorded. Next, determine the printing mode of the current slice by slicing the maximum printable distance and numerical simulation model. Then, based on Poiseuille flow, Jacobs working curve and Lambert-Beer law, the resin curing time of continuous and layered printing, the maximum filling distance of continuous printing, the best lifting distance of layered printing, and the corresponding printing platform lifting of the two methods are expressed speed. Finally, camera monitoring is used to determine the print origin before printing starts.

Abstract: A quinazoline compound and a pharmaceutically acceptable salt thereof, in particular a compound of formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).

Abstract: High intensity multi-directional FDM 3D printing method for stereo vision monitoring involves intelligent control and computer vision technology. Specifically, it involves multi-directional 3D printing hardware platform construction, stereo vision detection, laser heating to enhance the connection strength between various parts of the model, so as to reduce the use of external support structure as much as possible on the premise of ensuring the printing accuracy, and make the various parts of the model can be well connected to enhance the integrity of the model.

Abstract: A model-adaptive multi-source large-scale mask projection 3D printing system configured to conduct the following steps: projecting pure-color images of first and second colors having identical attributes, capturing an image of an overlapping portion and calculating height and width information of the overlapping portion; splitting a pre-processed slice and respectively recording width and height information of two slices resulting from the splitting and generating two gray scale images having identical attributes thereto; counting power values of identical positions of slices in different gray scale values, performing a further calculation to obtain a projection mapping function, using the projection mapping function as a basis for performing optimization on gray scale interpolation of the generated images; and fusing the processed gray scale images and the originally split two slices to obtain a mask projection 3D printing slice having a uniform shaping brightness, and forming a final product.

Abstract: A 3D printing method employing an adaptive internal supporting structure, involving the steps of: S1—extracting images from a reference biological structure picture to obtain a multi-layer grid texture serving as a plurality of layer pictures for an internal supporting structure of a 3D model; S2—separating multi-layer structures of the model layer-by-layer, and performing binarization and hollowing processing on each layer to obtain a plurality of images; S3—merging each layer picture obtained in step S1 with a corresponding image obtained in step S2 to obtain a plurality of final slice layer structures; S4—determining a support region of the supporting structure in each slice layer according to strength requirements; S5—analyzing the model to perform adaptive structural design and adjusting its strength-material ratio; and S6—restoring the model by using a 3D reconstruction algorithm and printing the model.

Abstract: Disclosed in the present invention are a crystal form and salt form of a TGF-?R1 inhibitor and a preparation method therefor, and further disclosed is an application of the crystal form and the salt form in preparation of medicines for treating cancers.

Abstract: A multi-degree-of-freedom (Multi-DOF) 3D printing device includes a printer mechanism, a rotatable platform, a visual inspection system, and a control system. The printing mechanism includes a print head. The printing mechanism and the rotatable platform are combined to have three degrees of freedom of translation, and the rotatable platform has two degrees of freedom of rotation. The visual inspection system includes a camera mounted to nearby the print head and the relative position of camera and print head remains constant. The control system is configured to implement the printing process. The model is decomposed into several components, each of which could be printed in a single direction. After one component is printed out, the platform is then rotated so that the cutting plane for the component will be printed is horizontal.

Abstract: High intensity multi-directional FDM 3D printing method for stereo vision monitoring involves intelligent control and computer vision technology. Specifically, it involves multi-directional 3D printing hardware platform construction, stereo vision detection, laser heating to enhance the connection strength between various parts of the model, so as to reduce the use of external support structure as much as possible on the premise of ensuring the printing accuracy, and make the various parts of the model can be well connected to enhance the integrity of the model.

Abstract: Disclosed in the present invention are a crystal form and salt form of a TGF-?R1 inhibitor and a preparation method therefor, and further disclosed is an application of the crystal form and the salt form in preparation of medicines for treating cancers.

Abstract: A model-adaptive multi-source large-scale mask projection 3D printing system configured to conduct the following steps: projecting pure-color images of first and second colors having identical attributes, capturing an image of an overlapping portion and calculating height and width information of the overlapping portion; splitting a pre-processed slice and respectively recording width and height information of two slices resulting from the splitting and generating two gray scale images having identical attributes thereto; counting power values of identical positions of slices in different gray scale values, performing a further calculation to obtain a projection mapping function, using the projection mapping function as a basis for performing optimization on gray scale interpolation of the generated images; and fusing the processed gray scale images and the originally split two slices to obtain a mask projection 3D printing slice having a uniform shaping brightness, and forming a final product.

Abstract: Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).

Abstract: A light homogenization method for multi-source large-scale surface exposure 3D printing, comprising the following steps: projecting pure-color images of a first color and a second color having identical attributes capturing an image of an overlapping portion and calculating height and width information of the overlapping portion; splitting a pre-processed slice and respectively recording width and height information of two slices resulting from the splitting and generating two grayscale images having identical attributes thereto; counting power values of identical positions of slices in different grayscale values, performing a further calculation to obtain a projection mapping function, using the projection mapping function as a basis for performing optimization on grayscale interpolation of the generated images; and fusing the processed grayscale images and the originally split two slices to obtain a surface exposure 3D printing slice having a uniform brightness in final shaping.

Abstract: The present invention relates to a 7-(thiazol-5-yl)pyrrolopyrimidine compound as a TLR7 agonist, and particularly relates to a compound shown in formula (I), pharmaceutically acceptable salt and preparation method thereof, a pharmaceutical composition containing such a compound, and usage thereof in preparing an antiviral drug.

Abstract: The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection.

Abstract: A benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-?R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).

Abstract: A multi-degree-of-freedom (Multi-DOF) 3D printing device includes a printer mechanism, a rotatable platform, a visual inspection system, and a control system. The printing mechanism includes a print head. The printing mechanism and the rotatable platform are combined to have three degrees of freedom of translation, and the rotatable platform has two degrees of freedom of rotation. The visual inspection system includes a camera mounted to nearby the print head and the relative position of camera and print head remains constant. The control system is configured to implement the printing process. The model is decomposed into several components, each of which could be printed in a single direction. After one component is printed out, the platform is then rotated so that the cutting plane for the component will be printed is horizontal.

Abstract: A light homogenization method for multi-source large-scale surface exposure 3D printing, comprising the following steps: projecting pure-color images of a first color and a second color having identical attributes, capturing an image of an overlapping portion and calculating height and width information of the overlapping portion; splitting a pre-processed slice and respectively recording width and height information of two slices resulting from the splitting and generating two grayscale images having identical attributes thereto; counting power values of identical positions of slices in different grayscale values, performing a further calculation to obtain a projection mapping function, using the projection mapping function as a basis for performing optimization on grayscale interpolation of the generated images; and fusing the processed grayscale images and the originally split two slices to obtain a surface exposure 3D printing slice having a uniform brightness in final shaping.

Abstract: A benzotriazole-derived ? and ?-unsaturated amide compound used as TGF-?R1 inhibitor or a pharmaceutically acceptable salt thereof, the structure of the compound being as shown in formula (I).