Patents by Inventor Liga Zvejniece

Liga Zvejniece has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures
    Patent number: 10105348
    Abstract: Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 23, 2018
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the Treatment of Seizures
    Publication number: 20180200227
    Abstract: Use of 2-(55-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Application
    Filed: August 2, 2016
    Publication date: July 19, 2018
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF DISEASES ASSOCIATED WITH ELEVATED INDUCIBLE NITRIC OXIDE SYNTHASE
    Publication number: 20180064687
    Abstract: The invention relates to the new medical use of (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide for the treatment of pathological conditions, including sepsis and peripheral neuropathy, characterized by overexpression of iNOS gene.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 8, 2018
    Inventors: Liga ZVEJNIECE, Maija DAMBROVA, Grigorijs VEINBERGS, Maksims VORONA, Ivars KALVINS
  • PHARMACEUTICAL COMPOSITION FOR CONTROLLING BODY MASS GAIN COMPRISING S-PHENOTROPIL
    Publication number: 20160250185
    Abstract: The invention relates to medicine, in particular S-Phenotropil ((S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide) containing pharmaceutical compositions and their use in control of body mass gain.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 1, 2016
    Applicant: Latvian Institute of Organic Synthesis
    Inventors: Ivars KALVINS, Liga ZVEJNIECE, Larisa VARACEVA, Aleksandrs CERNOBROVIJS, Antons LEBEDEVS, Maija DAMBROVA, Baiba SVALBE, Edgars LIEPINS
  • N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9382203
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 5, 2016
    Assignee: JOINT STOCK COMPANY (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • N-Carbamoylmethy1-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use
    Patent number: 9102615
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: August 11, 2015
    Assignee: Joint Stock Company (JSC) “OLAINFARM”
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • N-Carbamoylmethyl-4-(R)-Phenyl-2-Pyrrolidinone, Method of its Preparation and Pharmaceutical Use
    Publication number: 20150216846
    Abstract: The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.
    Type: Application
    Filed: April 16, 2015
    Publication date: August 6, 2015
    Inventors: Grigory Veinberg, Maksim Vorona, Liga Zvejniece, Aleksandrs Chernobrovijs, Ivars Kalvinsh, Ligita Karina, Maija Dambrova
  • 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY
    Publication number: 20140296317
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Ivars KALVINS, Antons LEBEDEVS, Aleksandrs CERNOBROVIJS, Maija DAMBROVA, Liga ZVEJNIECE, Maksims VORONA, Grigorijs VEINBERGS
  • 4,5-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity
    Patent number: 8791273
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: July 29, 2014
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs
  • 4R,5S-ENANTIOMER OF 2-(5-METHYL-2-OXO-4-PHENYL-PYRROLIDIN-1-YL)-ACETAMIDE WITH NOOTROPIC ACTIVITY
    Publication number: 20120215010
    Abstract: The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.
    Type: Application
    Filed: November 4, 2010
    Publication date: August 23, 2012
    Applicant: JSC Grindeks
    Inventors: Ivars Kalvins, Antons Lebedevs, Aleksandrs Cernobrovijs, Maija Dambrova, Liga Zvejniece, Maksims Vorona, Grigorijs Veinbergs