Patents by Inventor Ligang Qian

Ligang Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11553713
    Abstract: Disclosed are compositions and methods of pest control. The composition contains one or more active agents such as a polyalcohol, carbohydrate, nucleobase or nucleotide compound or derivative and one or more inactive ingredients which function as attractants or nutrients. The combination of the active agent(s) and the inactive ingredients achieves synergistic effect in pest control.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: January 17, 2023
    Inventors: Chunbo Zhang, Ligang Qian, Hongyue Zhang
  • Publication number: 20220380310
    Abstract: A compound has Formula I: R1 is hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, aryl, heteroaryl, —NR7R8, —CO—R10, or —NH—CO—R10; L is a bond, a heterocyclic bivalent group, a heteroaromatic bivalent group, or an aromatic bivalent group; M is a bond, alkyl, aryl, heterocyclic bivalent group, heteroaromatic bivalent group, or aromatic bivalent group; X is a bond, —O—, —S—, —SO2—, —CO—, —NR9—, —(CH2)m—, or heterocyclic bivalent group, m is 1, 2, 3, 4, 5, or 6; Y is a bond, —NH—, heterocyclic bivalent group, heteroaromatic bivalent group, bivalent benzyl group, or aromatic bivalent group; and Z is hydrogen, halogen, alkyl, aryl, heterocyclyl, heteroaryl, —NR7R8, —CO—R10, or —NH—CO—R10; R7, R8, and R9 are independently hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkyamino, heterocyclyl, or heteroaryl; and R10 is —O-tert-butyl, —CH2CH2-phenyl, hydrogen, hydroxy, halogen, nitro, amino, alkyl, alkoxy, alkylam
    Type: Application
    Filed: June 29, 2020
    Publication date: December 1, 2022
    Inventors: Ligang QIAN, Chunbo ZHANG
  • Publication number: 20200236932
    Abstract: Disclosed are compositions and methods of pest control. The composition contains one or more active agents such as a polyalcohol, carbohydrate, nucleobase or nucleotide compound or derivative and one or more inactive ingredients which function as attractants or nutrients. The combination of the active agent(s) and the inactive ingredients achieves synergistic effect in pest control.
    Type: Application
    Filed: September 21, 2016
    Publication date: July 30, 2020
    Inventors: Chunbo Zhang, Ligang Qian, Hongyue Zhang
  • Patent number: 7820814
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: October 26, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Publication number: 20090170853
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: March 6, 2009
    Publication date: July 2, 2009
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Patent number: 7547711
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: February 8, 2006
    Date of Patent: June 16, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Rajeev S. Bhide, John S. Tokarski, Peter Zheng, Ligang Qian, Zhen-Wei Cai
  • Patent number: 7521450
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Publication number: 20070299075
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: August 2, 2007
    Publication date: December 27, 2007
    Inventors: Rajeev Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Patent number: 7265113
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: September 4, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Patent number: 7244733
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: July 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
  • Patent number: 7112675
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: September 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
  • Patent number: 7102002
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: September 5, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zhen-wei Cai, Louis J. Lombardo, Rajeev S. Bhide, Ligang Qian, Donna D. Wei, Stephanie Barbosa
  • Patent number: 7084160
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: August 1, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Rajeev S. Bhide, John S. Tokarski, Peter Zheng, Ligang Qian, Zhen-Wei Cai
  • Publication number: 20060135576
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: February 8, 2006
    Publication date: June 22, 2006
    Inventors: Robert Borzilleri, Rajeev Bhide, John Tokarski, Peter Zheng, Ligang Qian, Zhen-Wei Cai
  • Publication number: 20060128709
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: February 2, 2006
    Publication date: June 15, 2006
    Inventors: John Hunt, Rajeev Bhide, Robert Borzilleri, Ligang Qian
  • Publication number: 20060009454
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: June 14, 2005
    Publication date: January 12, 2006
    Inventors: Zhen-wei Cai, Louis Lombardo, Rajeev Bhide, Ligang Qian, Donna Wei, Stephanie Barbosa
  • Publication number: 20060004007
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: July 27, 2005
    Publication date: January 5, 2006
    Inventors: John Hunt, Rajeev Bhide, Robert Borzilleri, Ligang Qian
  • Patent number: 6982265
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: January 3, 2006
    Assignee: Bristol Myers Squibb Company
    Inventors: John T. Hunt, Rajeev S. Bhide, Robert Michael Borzilleri, Ligang Qian
  • Patent number: 6933386
    Abstract: The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: August 23, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Rajeev S. Bhide, Junying Fan, Luca Parlanti, Stephanie Barbosa, Ligang Qian, Zhen-Wei Cai, Francis S. Gibson
  • Publication number: 20050124621
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: January 13, 2005
    Publication date: June 9, 2005
    Inventors: Rajeev Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl